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Showing papers in "Hepatology in 2005"



Journal ArticleDOI
TL;DR: The prevention of Cirrhosis can prevent the development of HCC and progression from chronic HCV infection to advanced fibrosis or cirrhosis may be prevented in 40% of patients who are sustained responders to new antiviral strategies, such as pegylated interferon and ribavirin.

5,557 citations


Journal ArticleDOI
TL;DR: In conclusion, acetaminophen hepatotoxicity far exceeds other causes of acute liver failure in the United States, and education of patients, physicians, and pharmacies to limit high‐risk use settings is recommended.

1,705 citations



Journal ArticleDOI
TL;DR: Noninvasive assessment of liver stiffness with transient elastography appears as a reliable tool to detect significant fibrosis or cirrhosis in patients with chronic hepatitis C.

1,424 citations


Journal ArticleDOI
TL;DR: NAFLD is highly prevalent in the general population, is not associated with SLD, but is associated with many features of the metabolic syndrome.

1,223 citations


Journal ArticleDOI
TL;DR: This document has been designated as a Position Paper, since the topic contains more data based on expert opinion than on randomized controlled trials and is thus not considered to have the emphasis and certainty of a Practice Guideline.

879 citations


Journal ArticleDOI
TL;DR: Intended for use by physicians, these recommendations suggest preferred approaches to the diagnostic, therapeutic, and preventive aspects of care to be flexible, in contrast to standards of care, which are inflexible policies to be followed in every case.

869 citations


Journal ArticleDOI
TL;DR: The ability of insulin‐sensitizing, pharmacological agents to treat NAFLD by reducing IR in the liver (metformin) and in the periphery (thiazolidinediones) are discussed.

804 citations


Journal ArticleDOI
TL;DR: This review aims to highlight current thinking regarding albumin therapy in the critical care and hepatological setting and also discusses other potential therapeutic applications for its use based around the complex biochemistry of this multifunctional plasma protein.

786 citations


Journal ArticleDOI
TL;DR: Type 1 and type 2 NASH are distinct subtypes of pediatric NAFLD, andtype 2 is the most common pattern in children, and NASH subtypes should be considered when interpreting liver biopsies and planning studies of the pathophysiology, genetics, natural history, or response to treatment in pediatricNAFLD.

Journal ArticleDOI
TL;DR: This review delineates multiple mechanisms involved in the process of BT, with an emphasis on alterations in intestinal flora and mucosal barrier function, particularly immunological defense mechanisms.

Journal ArticleDOI
TL;DR: In this paper, the authors used a thrombin generation test to investigate the coagulation function in patients with cirrhosis, and they found that the reduction of pro-coagulant factors in patients had little impact on the reduction in anticoagulants.

Journal ArticleDOI
TL;DR: The Barcelona Clinic Liver Cancer (BCLC) staging system had the best independent predictive power for survival when compared with the other 6 prognostic systems and provided the best prognostic stratification for this cohort of patients with HCC.

Journal ArticleDOI
TL;DR: Evidence of endothelial dysfunction and increased risk of cardiovascular events in NAFLD is provided, and particularly in nonalcoholic steatohepatitis.

Journal ArticleDOI
TL;DR: Whereas the Fibrometer has a high diagnostic accuracy for clinically significant fibrosis, blood tests for the area of liver fibrosis provide a quantitative estimation of the amount of fibrosis which is especially useful in cirrhosis.

Journal ArticleDOI
TL;DR: Environmental factors, possibly including infectious agents through urinary tract infections or chemicals contained in cigarette smoke, may induce PBC in genetically susceptible individuals and exogenous estrogens may also contribute to explain the female predominance of the disease.

Journal ArticleDOI
TL;DR: Age, aspartate aminotransferase (AST) and bilirubin were found to independently predict death or liver transplantation in the hepatocellular group, whereas among patients with cholestatic/mixed liver injury, bilirUBin was the only independent predictor.

Journal ArticleDOI
TL;DR: The level of experience (specialization, duration, and location of practice) has more influence on agreement than the characteristics of the specimen (length, fibrosis class number, miscellaneous factors).

Journal ArticleDOI
TL;DR: In conclusion, CSE‐derived H2S is involved in the maintenance of portal venous pressure and the reduction of CSE expression in the liver with cirrhosis contributes to the development of increased intrahepatic resistance and portal hypertension.

Journal ArticleDOI
TL;DR: The data indicate that hepatorenal syndrome is the result of a decrease in cardiac output in the setting of a severe arterial vasodilation, and plasma renin activity and cardiac output were the only independent predictors of hepat Lorenal syndrome.

Journal ArticleDOI
TL;DR: Chronic HBV patients harbor an increased percentage of Treg in peripheral blood compared with controls, which could contribute to an inadequate immune response against the virus, leading to chronic infection.

Journal ArticleDOI
TL;DR: MELD is a useful clinical tool for gauging mortality and guiding treatment decisions in patients with AH, particularly those complicated by ascites and/or encephalopathy, and maintains some practical and statistical advantages over DF in predicting mortality rate in these patients.

Journal ArticleDOI
TL;DR: The noninvasive EASL criteria for diagnosis of HCC are satisfied in only 61% of small nodules in cirrhosis; thus, biopsy frequently is required in this setting.

Journal ArticleDOI
TL;DR: Intended for use by physicians, these recommendations suggest preferred approaches to the diagnostic, therapeutic, and preventative aspects of care intended to be flexible, in contrast to standards of care, which are inflexible policies designed to be followed in every case.

Journal ArticleDOI
TL;DR: In conclusion, hypoxemia of HPS is frequently progressive and as OLT outcome relates to pretransplantation PaO2, additional MELD points should advance the priority for OLT in HPS.

Journal ArticleDOI
TL;DR: The repopulation, organization, and function of human hepatocytes in a mouse recipient and the infections with hepatitis B virus (HBV) and hepatitis C virus (HCV) of the transplanted cells are described.

Journal ArticleDOI
TL;DR: In a sizeable proportion of patients with advanced HCV, LADR may render blood free of HCV RNA, stabilize clinical course, and prevent posttransplantation recurrence.

Journal ArticleDOI
TL;DR: Addition of serum sodium to MELD increases the ability to predict 3‐ and 6‐month mortality in patients with cirrhosis and is a strong independent predictor of mortality.

Journal ArticleDOI
TL;DR: In conclusion, active management of obesity and a reduction in steatosis may improve liver injury and decrease the progression of fibrosis.