Showing papers in "Hepatology in 2012"

TL;DR: This is a practice guideline for clinicians rather than a review article and interested readers can refer to several comprehensive reviews published recently.

TL;DR: The aim was to build an algorithm along with a scoring system for histopathologic classification of liver lesions that covers the entire spectrum of lesions in morbidly obese patients, and suggest describing liver lesions using the SAF score.

TL;DR: The results of this study show that real‐time SWE is more accurate than TE in assessing significant fibrosis (≥F2) and has the advantage of imaging liver stiffness in real time while guided by a B‐mode image.

TL;DR: The results suggest that circulating miRNAs may serve as biomarkers to differentiate between hepatocyte injury and inflammation and the exosome versus protein association of mi RNAs may provide further specificity to mechanisms of liver pathology.

TL;DR: The model was most sensitive to estimates of age‐specific incidence of HEV disease, which causes source‐originated epidemics of acute disease with a case fatality rate thought to vary by age and pregnancy status.

TL;DR: Multiresistant bacteria, especially ESBL‐producing Enterobacteriaceae, are frequently isolated in nosocomial and, to a lesser extent, HCA infections in cirrhosis, rendering third‐generation cephalosporins clinically ineffective.

TL;DR: Compared with the M probe, the FibroScan XL probe reduces TE failure and facilitates reliable LSM in obese patients, and lower liver stiffness cutoffs will be necessary when the XL probe is used to noninvasively assess liver fibrosis.

TL;DR: It is concluded that SF is useful to identify NAFLD patients at risk for NASH and advanced fibrosis and is an independent predictor of advanced hepatic fibrosis among patients withNAFLD.

TL;DR: Family history of diabetes, especially among nondiabetics, is associated with NASH and fibrosis in NAFLD, and diabetes is strongly associated with risk of NASH, fibrosis, and advanced fibrosis.

TL;DR: Fulminant Wilson's disease can be diagnosed most effectively not by waiting for copper levels (too slow to obtain) or by obtaining ceruloplasmin levels (low in half of all ALF patients, regardless of etiology), but by simply looking for the more readily available bilirubin level and alkaline phosphatase (ALP; very low).

TL;DR: It is shown that the numbers of Tim‐3+ tumor‐infiltrating cells were negatively associated with patient survival and the data suggest that this pathway could be an immunotherapeutic target in patients with HBV‐associated HCC.

TL;DR: Findings indicate that miR‐7 functions as a tumor suppressor and plays a substantial role in inhibiting the tumorigenesis and reversing the metastasis of HCC through the PI3K/Akt/mTOR‐signaling pathway in vitro and in vivo.

TL;DR: It is found that APAP overdose induces autophagy, which attenuates APAP‐induced liver cell death by removing damaged mitochondria, which suggests APAP mitochondrial protein binding and the subsequent production of reactive oxygen species may play an important role in AP AP‐induced autophagic flux assays.

TL;DR: The analysis suggests that the number of FB persons living with CHB in the United States may be significantly greater than previously reported, and may be as high as 2.2 million.

TL;DR: The data indicate that fewer than half of those infected with HCV may be aware of their infection, and suggest that more intensive efforts are needed to identify and test persons at risk for HCV infection.

TL;DR: Cirrhosis regression and decreased fibrosis are frequently observed among HCV patients with cirrhosis with an SVR, and portal inflammation and sinusoidal capillarization may not regress after viral eradication.

TL;DR: Deregulation of lncRNA MVIH is a predictor for poor RFS of HCC patients after hepatectomy and could be utilized as a potential target for new adjuvant therapies against active angiogenesis.

TL;DR: Patients with NAFLD were insulin resistant at the level of adipose tissue, liver, and skeletal muscle and had higher plasma aspartate aminotransferase and alanine aminotsferase, triglycerides, and lower high‐density lipoprotein cholesterol and adiponectin levels.

TL;DR: Clarifying fibrosis‐dependent tumorigenic mechanisms will help rationalize antifibrotic therapies as a strategy to prevent and treat HCC.

TL;DR: IL‐22 induces the senescence of HSCs, which express both IL‐10R2 and IL‐22R1, thereby ameliorating liver fibrogenesis, in addition to the previously discovered hepatoprotective functions of IL‐ 22.

TL;DR: The current study clearly elucidates the underlying molecular mechanism of hepatic versus intestinal Fxr in regulating the expression of genes critical for bile‐acid synthesis and hydrophobicity in the liver.

TL;DR: Potentially preventable second infections are predictors of mortality independent of liver disease severity in this multicenter cirrhosis cohort.

TL;DR: Dual therapy with daclatasvir and asunaprevir, without Peg‐IFN and RBV, can achieve high SVR rates in difficult‐to‐treat patients with HCV genotype 1b infection and previous null response to Peg‐ifN andRBV.

TL;DR: Investigation of the role of CXCL5 in tumor growth, invasion, and prognosis of hepatocellular carcinoma found that CxCL5 expression was increased in the highly metastatic HCC cell lines and in tumor tissues from patients with recurrent HCC compared to controls, and C XCL5 is a potential therapeutic target for HCC.

TL;DR: Evidence is provided that albumin reduces morbidity and mortality among patients with tense ascites undergoing large‐volume paracentesis, as compared with alternative treatments investigated thus far.

TL;DR: Coffee CC is associated with a significant reduction in risk of fibrosis among NASH patients, and Spearman's rank correlation analysis supported a negative relationship between coffee CC and hepatic fibrosis.

TL;DR: Over a 5‐year period, on‐treatment liver stiffness appears stable in most noncirrhotic PBC patients, whereas it significantly increases in patients with cirrhosis, and progression of liver stiffness in PBC is predictive of poor outcome.

TL;DR: Chemokines and mitochondrial products collaborate in neutrophil‐mediated injury and systemic inflammation during acute liver failure and the release of necrotic products into the circulation may trigger a systemic inflammatory response and remote lung injury.

TL;DR: Hepatitis C virus‐induced miR‐155 expression promotes hepatocyte proliferation and tumorigenesis by activating Wnt signaling in vitro and in vivo and adenomatous polyposis coli (APC) was identified as the direct and functional target of miR•155.

TL;DR: An efficient and rapid three‐step protocol that is able to rapidly generate hepatocyte‐like cells from human iPSCs that rescued lethal fulminant hepatic failure in a nonobese diabetic severe combined immunodeficient mouse model is described.