Showing papers in "IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control in 2011"

Ultrafast compound doppler imaging: providing full blood flow characterization

Abstract: Doppler-based flow analysis methods require acquisition of ultrasound data at high spatio-temporal sampling rates. These rates represent a major technical challenge for ultrasound systems because a compromise between spatial and temporal resolution must be made in conventional approaches. Consequently, ultrasound scanners can either provide full quantitative Doppler information on a limited sample volume (spectral Doppler), or averaged Doppler velocity and/or power estimation on a large region of interest (Doppler flow imaging). In this work, we investigate a different strategy for acquiring Doppler information that can overcome the limitations of the existing Doppler modes by significantly reducing the required acquisition time. This technique is called ultrafast compound Doppler imaging and is based on the following concept: instead of successively insonifying the medium with focused beams, several tilted plane waves are sent into the medium and the backscattered signals are coherently summed to produce high-resolution ultrasound images. We demonstrate that this strategy allows reduction of the acquisition time by a factor of up to of 16 while keeping the same Doppler performance. Depending on the application, different directions to increase performance of Doppler analysis are proposed and the improvement is quantified: the ultrafast compound Doppler method allows faster acquisition frame rates for high-velocity flow imaging, or very high sensitivity for low-flow applications. Full quantitative Doppler flow analysis can be performed on a large region of interest, leading to much more information and improved functionality for the physician. By leveraging the recent emergence of ultrafast parallel beamforming systems, this paper demonstrates that breakthrough performances in flow analysis can be reached using this concept of ultrafast compound Doppler.

Short-lag spatial coherence of backscattered echoes: imaging characteristics

Abstract: Conventional ultrasound images are formed by delay-and-sum beamforming of the backscattered echoes received by individual elements of the transducer aperture. Although the delay-and-sum beamformer is well suited for ultrasound image formation, it is corrupted by speckle noise and challenged by acoustic clutter and phase aberration. We propose an alternative method of imaging utilizing the short-lag spatial coherence (SLSC) of the backscattered echoes. Compared with matched B-mode images, SLSC images demonstrate superior SNR and contrast-to-noise ratio in simulated and experimental speckle-generating phantom targets, but are shown to be challenged by limited point target conspicuity. Matched B-mode and SLSC images of a human thyroid are presented. The challenges and opportunities of real-time implementation of SLSC imaging are discussed.

Nonlinear dielectric thin films for high-power electric storage with energy density comparable with electrochemical supercapacitors

Abstract: Although batteries possess high energy storage density, their output power is limited by the slow movement of charge carriers, and thus capacitors are often required to deliver high power output. Dielectric capacitors have high power density with fast discharge rate, but their energy density is typically much lower than electrochemical supercapacitors. Increasing the energy density of dielectric materials is highly desired to extend their applications in many emerging power system applications. In this paper, we review the mechanisms and major characteristics of electric energy storage with electrochemical supercapacitors and dielectric capacitors. Three types of in-house-produced ferroic nonlinear dielectric thin film materials with high energy density are described, including (Pb0.97La0.02)(Zr0.90Sn0.05Ti0.05)O3 (PLZST) antiferroelectric ceramic thin films, Pb(Zn1/3Nb2/3)O3-Pb(Mg1/3Nb2/3) O3-PbTiO3 (PZN-PMN-PT) relaxor ferroelectric ceramic thin films, and poly(vinylidene fluoride) (PVDF)-based polymer blend thin films. The results showed that these thin film materials are promising for electric storage with outstandingly high power density and fairly high energy density, comparable with electrochemical supercapacitors.

On the effects of reflected waves in transient shear wave elastography

Abstract: In recent years, novel quantitative techniques have been developed to provide noninvasive and quantitative stiffness images based on shear wave propagation. Using radiation force and ultrafast ultrasound imaging, the supersonic shear imaging technique allows one to remotely generate and follow a transient plane shear wave propagating in vivo in real time. The tissue shear modulus, i.e., its stiffness, can then be estimated from the shear wave local velocity. However, because the local shear wave velocity is estimated using a time-of-flight approach, reflected shear waves can cause artifacts in the estimated shear velocity because the incident and reflected waves propagate in opposite directions. Such effects have been reported in the literature as a potential drawback of elastography techniques based on shear wave speed, particularly in the case of high stiffness contrasts, such as in atherosclerotic plaque or stiff lesions. In this letter, we present our implementation of a simple directional filter, previously used for magnetic resonance elastography, which separates the forward- and backward-propagating waves to solve this problem. Such a directional filter could be applied to many elastography techniques based on the local estimation of shear wave speed propagation, such as acoustic radiation force imaging (ARFI), shearwave dispersion ultrasound vibrometry (SDUV), needle-based elastography, harmonic motion imaging, or crawling waves when the local propagation direction is known and high-resolution spatial and temporal data are acquired.

Study and comparison of different EMAT configurations for SH wave inspection

Abstract: Guided wave inspection has proven to be a very effective method for the rapid inspection of large structures. The fundamental shear horizontal (SH) wave mode in plates and the torsional mode in pipe-like structures are especially useful because of their non-dispersive character. Guided waves can be generated by either piezoelectric transducers or electro- magnetic acoustic transducers (EMATs), and EMATs can be based on either the Lorentz force or magnetostriction. Several EMAT configurations can be used to produce SH waves, the most common being Lorentz-force periodic permanent magnet and magnetostrictive EMATs, the latter being directly applied on the sample or with a bonded strip of highly magnetostrictive material on the plate. This paper compares the performance of these solutions on steel structures. To quantitatively assess the wave amplitude produced by different probes, a finite element model of the elementary transducers has been developed. The results of the model are experimentally validated and the simulations are further used to study the dependence of ultrasonic wave amplitude on key design parameters. The analysis shows that magnetostrictive EMATs directly applied on mild steel plates have comparatively poor performance that is dependent on the precise magneto-mechanical properties of the test object. Periodic permanent magnet EMATs generate intermediate wave amplitudes and are noncontact and insensitive to the variations in properties seen across typical steels. Large signal amplitudes can be achieved with magnetostrictive EMATs with a layer of highly magnetostrictive material attached between the transducer and the plate, but this compromises the noncontact nature of the transducer.

Front-end receiver electronics for high-frequency monolithic CMUT-on-CMOS imaging arrays

Abstract: This paper describes the design of CMOS receiver electronics for monolithic integration with capacitive micromachined ultrasonic transducer (CMUT) arrays for high-frequency intravascular ultrasound imaging. A custom 8-inch (20-cm) wafer is fabricated in a 0.35-μm two-poly, four-metal CMOS process and then CMUT arrays are built on top of the application specific integrated circuits (ASICs) on the wafer. We discuss advantages of the single-chip CMUT-on-CMOS approach in terms of receive sensitivity and SNR. Low-noise and high-gain design of a transimpedance amplifier (TIA) optimized for a forward-looking volumetric-imaging CMUT array element is discussed as a challenging design example. Amplifier gain, bandwidth, dynamic range, and power consumption trade-offs are discussed in detail. With minimized parasitics provided by the CMUT-on-CMOS approach, the optimized TIA design achieves a 90 fA/√Hz input-referred current noise, which is less than the thermal-mechanical noise of the CMUT element. We show successful system operation with a pulseecho measurement. Transducer-noise-dominated detection in immersion is also demonstrated through output noise spectrum measurement of the integrated system at different CMUT bias voltages. A noise figure of 1.8 dB is obtained in the designed CMUT bandwidth of 10 to 20 MHz.

GPU-based beamformer: Fast realization of plane wave compounding and synthetic aperture imaging

Abstract: Although they show potential to improve ultrasound image quality, plane wave (PW) compounding and synthetic aperture (SA) imaging are computationally demanding and are known to be challenging to implement in real-time. In this work, we have developed a novel beamformer architecture with the real-time parallel processing capacity needed to enable fast realization of PW compounding and SA imaging. The beamformer hardware comprises an array of graphics processing units (GPUs) that are hosted within the same computer workstation. Their parallel computational resources are controlled by a pixel-based software processor that includes the operations of analytic signal conversion, delay-and-sum beamforming, and recursive compounding as required to generate images from the channel-domain data samples acquired using PW compounding and SA imaging principles. When using two GTX-480 GPUs for beamforming and one GTX-470 GPU for recursive compounding, the beamformer can compute compounded 512 × 255 pixel PW and SA images at throughputs of over 4700 fps and 3000 fps, respectively, for imaging depths of 5 cm and 15 cm (32 receive channels, 40 MHz sampling rate). Its processing capacity can be further increased if additional GPUs or more advanced models of GPU are used.

Review of shell models for contrast agent microbubbles

Abstract: Micrometer-scale encapsulated gas bubbles, known as ultrasound contrast agents, are used in ultrasound medical diagnostics for enhancing blood-tissue contrast during an ultrasonic examination. They are also employed in therapy as an activator of drug incorporation or extravasation. Adequate modeling of the effect of encapsulation is of primary importance because it is the encapsulating shell that determines many of the functional properties of contrast agents. In this review, existing approaches to the modeling of the radial motion of an encapsulated bubble are discussed and comparative analysis of available shell models is conducted. The capabilities of the shell models are evaluated in the context of recent experimental observations, such as compression-only behavior and the dependence of shell material properties on initial bubble radius. It is shown that for early shell models, the main problem is that the behavior of encapsulation is described by linear elastic and viscous laws, whereas recent experimental data attest to complicated rheological properties inherent in shell materials. Currently, a trend toward models involving nonlinear laws for shell elasticity and viscosity is observed. In particular, nonlinear models have been proposed that allow one to reproduce compression-only behavior. However, the problem of the radius dependence of shell material parameters remains unsolved.

High-temperature (>500°c) wall thickness monitoring using dry-coupled ultrasonic waveguide transducers

Abstract: Conventional ultrasonic transducers cannot withstand high temperatures for two main reasons: the piezoelectric elements within them depolarize, and differential thermal expansion of the different materials within a transducer causes them to fail. In this paper, the design of a high-temperature ultrasonic thickness gauge that bypasses these problems is described. The system uses a waveguide to isolate the vulnerable transducer and piezoelectric elements from the high-temperature measurement zone. Use of thin and long waveguides of rectangular cross section allows large temperature gradients to be sustained over short distances without the need for additional cooling equipment. The main problems that had to be addressed were the transmission and reception of ultrasonic waves into and from the testpiece that the waveguides are coupled to, and optimization of the wave propagation along the waveguide itself. It was found that anti-plane shear loading performs best at transmitting and receiving from the surface of a component that is to be inspected. Therefore, a nondispersive guided wave mode in large-aspect-ratio rectangular strips was employed to transmit the anti-plane shear loading from the transducer to the measurement zone. Different joining methods to attach the waveguides to the component were investigated and experiments showed that clamping the waveguides to the component surface gave the best results. The thickness of different plate samples was consistently measured to within less than 0.1 mm. Performance at high temperatures was tested in a furnace at 730°C for 4 weeks without signal degradation. Thicknesses in the range of 3 to 25 mm could be monitored using Hanning windowed tonebursts with 2 MHz center frequency.

Sources of image degradation in fundamental and harmonic ultrasound imaging using nonlinear, full-wave simulations

Abstract: A full-wave equation that describes nonlinear propagation in a heterogeneous attenuating medium is solved numerically with finite differences in the time domain (FDTD). This numerical method is used to simulate propagation of a diagnostic ultrasound pulse through a measured representation of the human abdomen with heterogeneities in speed of sound, attenuation, density, and nonlinearity. Conventional delay-andsum beamforming is used to generate point spread functions (PSF) that display the effects of these heterogeneities. For the particular imaging configuration that is modeled, these PSFs reveal that the primary source of degradation in fundamental imaging is reverberation from near-field structures. Reverberation clutter in the harmonic PSF is 26 dB higher than the fundamental PSF. An artificial medium with uniform velocity but unchanged impedance characteristics indicates that for the fundamental PSF, the primary source of degradation is phase aberration. An ultrasound image is created in silico using the same physical and algorithmic process used in an ultrasound scanner: a series of pulses are transmitted through heterogeneous scattering tissue and the received echoes are used in a delay-and-sum beamforming algorithm to generate images. These beamformed images are compared with images obtained from convolution of the PSF with a scatterer field to demonstrate that a very large portion of the PSF must be used to accurately represent the clutter observed in conventional imaging.

Combined passive detection and ultrafast active imaging of cavitation events induced by short pulses of high-intensity ultrasound

Abstract: The activation of natural gas nuclei to induce larger bubbles is possible using short ultrasonic excitations of high amplitude, and is required for ultrasound cavitation therapies. However, little is known about the distribution of nuclei in tissues. Therefore, the acoustic pressure level necessary to generate bubbles in a targeted zone and their exact location are currently difficult to predict. To monitor the initiation of cavitation activity, a novel all-ultrasound technique sensitive to single nucleation events is presented here. It is based on combined passive detection and ultrafast active imaging over a large volume using the same multi-element probe. Bubble nucleation was induced using a focused transducer (660 kHz, f-number = 1) driven by a high-power electric burst (up to 300 W) of one to two cycles. Detection was performed with a linear array (4 to 7 MHz) aligned with the single-element focal point. In vitro experiments in gelatin gel and muscular tissue are presented. The synchronized passive detection enabled radio-frequency data to be recorded, comprising high-frequency coherent wave fronts as signatures of the acoustic emissions linked to the activation of the nuclei. Active change detection images were obtained by subtracting echoes collected in the unnucleated medium. These indicated the appearance of stable cavitating regions. Because of the ultrafast frame rate, active detection occurred as quickly as 330 μs after the high-amplitude excitation and the dynamics of the induced regions were studied individually.

Echocardiographic speckle reduction comparison

Abstract: In this paper, a detailed description and comparison of speckle reduction of medical ultrasound, and in particular echocardiography, is presented. Fifteen speckle reduction filters are described in a detailed fashion to facilitate implementation for research and evaluation. The filtering techniques considered include anisotropic diffusion, wavelet denoising, and local statistics. Common nomenclature and notation are adopted, to expedite comparison between approaches. Comparison of the filters is based on their application to simulated images, clinical videos, and a computational requirement analysis. The ultrasound simulation method provides a realistic model of the image acquisition process, and permits the use of a noise-free reference image for comparison. Application of objective quality metrics quantifies the preservation of image edges, overall image distortion, and improvement in image contrast. The computational analysis quantifies the number of operations required for each speckle reduction method. A speed-accuracy analysis of discretization methods for anisotropic diffusion is included. It is concluded that the optimal method is the OSRAD diffusion filter. This method is capable of strong speckle suppression, increasing the average SNRA of the simulated images by a factor of two. This method also shows favorable edge preservation and contrast improvement, and may be efficiently implemented.

Cyclic energy harvesting from pyroelectric materials

Abstract: A method of continuously harvesting energy from pyroelectric materials is demonstrated using an innovative cyclic heating scheme. In traditional pyroelectric energy harvesting methods, static heating sources are used, and most of the available energy has to be harvested at once. A cyclic heating system is developed such that the temperature varies between hot and cold regions. Although the energy harvested during each period of the heating cycle is small, the accumulated total energy over time may exceed traditional methods. Three materials are studied: a commonly available soft lead zirconate titanate (PZT), a pre-stressed PZT composite, and single-crystal PMN-30PT. Radiation heating and natural cooling are used such that, at smaller cyclic frequencies, the temporal rate of change in temperature is large enough to produce high power densities. The maximum power density of 8.64 μW/cm3 is generated with a PMN-30PT single crystal at an angular velocity of 0.64 rad/s with a rate of 8.5°C/s. The pre-stressed PZT composite generated a power density of 6.31 μW/cm3, which is 40% larger than the density of 4.48 μW/cm3 obtained from standard PZT.

Passive elastography: shear-wave tomography from physiological-noise correlation in soft tissues

Abstract: Inspired by seismic-noise correlation and time reversal, a shear-wave tomography of soft tissues using an ultrafast ultrasonic scanner is presented here. Free from the need for controlled shear-wave sources, this passive elastography is based on Green's function retrieval and takes advantage of the permanent physiological noise of the human body.

Contrast enhancement and robustness improvement of adaptive ultrasound imaging using forward-backward minimum variance beamforming

Abstract: In adaptive ultrasound imaging, accurate estimation of the array covariance matrix is of great importance, and biases the performance of the adaptive beamformer. The more accurately the covariance matrix can be estimated, the better the resolution and contrast can be achieved in the ultrasound image. To this end, in this paper, we have used the forwardbackward spatial averaging for array covariance matrix estimation, which is then employed in minimum variance (MV) weights calculation. The performance of the proposed forwardbackward MV (FBMV) beamformer is tested on simulated data obtained using Field II. Data for two closely located point targets surrounded by speckle pattern are simulated showing the higher amplitude resolution of the FBMV beamformer in comparison to the forward-only (F-only) MV beamformers, without the need for diagonal loading. A circular cyst with a diameter of 6 mm and a phantom containing wire targets and two cysts with different diameters of 8 mm and 6 mm are also simulated. The simulations show that the FBMV beamformer, in contrast to the F-only MV, could estimate the background speckle statistics without the need for temporal smoothing, resulting in higher contrast for the FBMV-resulted image in comparison to the MV images. In addition, the effect of steering vector errors is investigated by applying an error of the sound speed estimate to the ultrasound data. The simulations show that the proposed FBMV beamformer presents a satisfactory robustness against data misalignment resulted from steering vector errors, outperforming the regularized F-only MV beamformer. These improvements are achieved without compromising the good resolution of the MV beamformer and resulted from more accurate estimation of the covariance matrix and consequently, the more accurate setting of the MV weights.

A single vibration mode tubular piezoelectric ultrasonic motor

Abstract: A novel tubular ultrasonic motor is presented that uses only a single vibration bending mode of a piezoelectric tube to generate rotation. When the piezoelectric tube bends, the diagonal motion of points on selected areas at the ends of the tube generates forces with tangential components along the same circumferential direction, driving the rotors to rotate. Bi-directional motion is achieved by simply switching the direction of bending. Because only one vibration mode is used, the motor requires only one driving signal and no vibration mode coupling is needed, simplifying the design, fabrication, assembly, and operation of the device. Two prototypes [one with cut-in lead zirconate titanate (PZT) teeth and one with added metal teeth] were built and tested using PZT tubes available to the authors. The tubes have an outside diameter of 6.6 mm, inner diameter of 5.0 mm, and length of 25.4 mm. The working frequencies of the two motors are 27.6 and 23.5 kHz. The motors achieved a maximum no-load speed of 400 rpm and a stall torque of 300 μN·m.

A new piezoelectric energy harvesting design concept: multimodal energy harvesting skin

Abstract: This paper presents an advanced design concept for a piezoelectric energy harvesting (EH), referred to as multimodal EH skin. This EH design facilitates the use of multimodal vibration and enhances power harvesting efficiency. The multimodal EH skin is an extension of our previous work, EH skin, which was an innovative design paradigm for a piezoelectric energy harvester: a vibrating skin structure and an additional thin piezoelectric layer in one device. A computational (finite element) model of the multilayered assembly-the vibrating skin structure and piezoelectric layer-is constructed and the optimal topology and/or shape of the piezoelectric layer is found for maximum power generation from multiple vibration modes. A design rationale for the multimodal EH skin was proposed: designing a piezoelectric material distribution and external resistors. In the material design step, the piezoelectric material is segmented by inflection lines from multiple vibration modes of interests to minimize voltage cancellation. The inflection lines are detected using the voltage phase. In the external resistor design step, the resistor values are found for each segment to maximize power output. The presented design concept, which can be applied to any engineering system with multimodal harmonic-vibrating skins, was applied to two case studies: an aircraft skin and a power transformer panel. The excellent performance of multimodal EH skin was demonstrated, showing larger power generation than EH skin without segmentation or unimodal EH skin.

Broadband electrical impedance matching for piezoelectric ultrasound transducers

Abstract: This paper presents a systematic method for designing broadband electrical impedance matching networks for piezoelectric ultrasound transducers. The design process involves three steps: 1) determine the equivalent circuit of the unmatched piezoelectric transducer based on its measured admittance; 2) design a set of impedance matching networks using a computerized Smith chart; and 3) establish the simulation model of the matched transducer to evaluate the gain and bandwidth of the impedance matching networks. The effectiveness of the presented approach is demonstrated through the design, implementation, and characterization of impedance matching networks for a broadband acoustic emission sensor. The impedance matching network improved the power of the acquired signal by 9 times.

Synthetic aperture focusing of ultrasonic data from multilayered media using an omega-K algorithm

Abstract: The synthetic aperture focusing technique (SAFT) is used to create focused images from ultrasound scans. SAFT has traditionally been applied only for imaging in a single medium, but the recently introduced phase shift migration (PSM) algorithm has expanded the use of SAFT to multilayer structures. In this article we present a similar focusing algorithm called multi-layer omega-k (MULOK), which combines PSM and the ω-k algorithm to perform multilayer imaging more efficiently. The asymptotic complexity is shown to be lower for MULOK than for PSM, and this is confirmed by comparing execution times for implementations of both algorithms. To facilitate the complexity analysis, a detailed description of algorithm implementation is included, which also serves as a guide for readers interested in practical implementation. Using data from an experiment with a multilayered structure, we show that there is essentially no difference in image quality between the two algorithms.

80-MHz intravascular ultrasound transducer using PMN-PT free-standing film

Abstract: [Pb(Mg1/3Nb2/3)O3]0.63[PbTiO3]0.37 (PMN-PT) free-standing film of comparable piezoelectric properties to bulk material with thickness of 30 μm has been fabricated using a modified precursor coating approach. At 1 kHz, the dielectric permittivity and loss were 4364 and 0.033, respectively. The remnant polarization and coercive field were 28 μC/ cm2 and 18.43 kV/cm. The electromechanical coupling coefficient kt was measured to be 0.55, which was close to that of bulk PMN-PT single-crystal material. Based on this film, high-frequency (82 MHz) miniature ultrasonic transducers were fabricated with 65% bandwidth and 23 dB insertion loss. Axial and lateral resolutions were determined to be as high as 35 and 176 μ m. In vitro intravascular imaging on healthy rabbit aorta was performed using the thin film transducers. In comparison with a 35-MHz IVUS transducer, the 80-MHz transducer showed superior resolution and contrast with satisfactory penetration depth. The imaging results suggest that PMN-PT free-standing thin film technology is a feasible and efficient way to fabricate very-high-frequency ultrasonic transducers.

Monitoring of thermal therapy based on shear modulus changes: II. Shear wave imaging of thermal lesions

Abstract: The clinical applicability of high-intensity focused ultrasound (HIFU) for noninvasive therapy is currently hampered by the lack of robust and real-time monitoring of tissue damage during treatment. The goal of this study is to show that the estimation of local tissue elasticity from shear wave imaging (SWI) can lead to a precise mapping of the lesion. HIFU treatment and monitoring were respectively performed using a confocal setup consisting of a 2.5-MHz single element transducer focused at 34 mm on ex vivo samples and an 8-MHz ultrasound diagnostic probe. Ultrasound-based strain imaging was combined with shear wave imaging on the same device. The SWI sequences consisted of 2 successive shear waves induced at different lateral positions. Each wave was created with pushing beams of 100 μs at 3 depths. The shear wave propagation was acquired at 17,000 frames/s, from which the elasticity map was recovered. HIFU sonications were interleaved with fast imaging acquisitions, allowing a duty cycle of more than 90%. Thus, elasticity and strain mapping was achieved every 3 s, leading to real-time monitoring of the treatment. When thermal damage occurs, tissue stiffness was found to increase up to 4-fold and strain imaging showed strong shrinkages that blur the temperature information. We show that strain imaging elastograms are not easy to interpret for accurate lesion characterization, but SWI provides a quantitative mapping of the thermal lesion. Moreover, the concept of shear wave thermometry (SWT) developed in the companion paper allows mapping temperature with the same method. Combined SWT and shear wave imaging can map the lesion stiffening and temperature outside the lesion, which could be used to predict the eventual lesion growth by thermal dose calculation. Finally, SWI is shown to be robust to motion and reliable in vivo on sheep muscle.

Erratum: Sources of image degradation in fundamental and harmonic ultrasound imaging: a nonlinear, full-wave, simulation study [Apr 11 754-765]

Abstract: An earlier revision of this paper was mistakenly submitted for publication as the final draft Unfortunately, this was not discovered until after it appeared in print [1] The correct version of the paper is presented here

Porous piezoceramics: theory, technology, and properties

Abstract: A comprehensive review of porosity origin, microstructure peculiarities, fabrication methods, and mathematical models, as well as systematic experimental data for different porous piezoceramics with 3-0/3-3 connectivity is presented. New families of porous piezoceramics based on lead zirconate titanate (PZT), lead titanate, lead metaniobate, and sodium-potassium niobate compositions, with properties combining better parameters of PZT, PN-type ceramics, and 1-3 composites are introduced. Piezoelectric resonance analysis methods for automatic iterative evaluation of complex material parameters and the full sets of complex constants for different porous piezoceramics are presented. Numerical FEM calculations were critically compared with the results of various approximated formulas, unit cell models, and experimental data for different porous piezoceramics. Microstructural and physical mechanisms of losses and dispersion in porous piezoceramics, as well as technological aspects of their large-scale manufacture and application in ultrasonic devices were considered. The results of SEM microstructure analysis and microstructure-properties interrelations were discussed. Recent advances in fabrication methods for nano- and microporous piezoceramics and ceramic piezocomposites were discussed.

Monolithic CMUT-on-CMOS integration for intravascular ultrasound applications

Abstract: One of the most important promises of capacitive micromachined ultrasonic transducer (CMUT) technology is integration with electronics. This approach is required to minimize the parasitic capacitances in the receive mode, especially in catheter-based volumetric imaging arrays, for which the elements must be small. Furthermore, optimization of the available silicon area and minimized number of connections occurs when the CMUTs are fabricated directly above the associated electronics. Here, we describe successful fabrication and performance evaluation of CMUT arrays for intravascular imaging on custom-designed CMOS receiver electronics from a commercial IC foundry. The CMUT-on-CMOS process starts with surface isolation and mechanical planarization of the CMOS electronics to reduce topography. The rest of the CMUT fabrication is achieved by modifying a low-temperature micromachining process through the addition of a single mask and developing a dry etching step to produce sloped sidewalls for simple and reliable CMUT-to-CMOS interconnection. This CMUT-to-CMOS interconnect method reduced the parasitic capacitance by a factor of 200 when compared with a standard wire-bonding method. Characterization experiments indicate that the CMUT-on-CMOS elements are uniform in frequency response and are similar to CMUTs simultaneously fabricated on standard silicon wafers without electronics integration. Ex- periments on a 1.6-mm-diameter dual-ring CMUT array with a center frequency of 15 MHz show that both the CMUTs and the integrated CMOS electronics are fully functional. The SNR measurements indicate that the performance is adequate for imaging chronic total occlusions located 1 cm from the CMUT array.

Assessment of viscous and elastic properties of sub-wavelength layered soft tissues using shear wave spectroscopy: Theoretical framework and in vitro experimental validation

Abstract: In elastography, quantitative imaging of soft tissue elastic properties is provided by local shear wave speed estimation. Shear wave imaging in a homogeneous medium thicker than the shear wavelength is eased by a simple relationship between shear wave speed and local shear modulus. In thin layered organs, the shear wave is guided and thus undergoes dispersive effects. This case is encountered in medical applications such as elastography of skin layers, corneas, or arterial walls. In this work, we proposed and validated shear wave spectroscopy as a method for elastic modulus quantification in such layered tissues. Shear wave dispersion curves in thin layers were obtained by finite-difference simulations and numerical solving of the boundary conditions. In addition, an analytical approximation of the dispersion equation was derived from the leaky Lamb wave theory. In vitro dispersion curves obtained from phantoms were consistent with numerical studies (deviation <;1.4%). The least-mean-squares fitting of the dispersion curves enables a quantitative and accurate (error <;5% of the transverse speed) assessment of the elasticity. Dispersion curves were also found to be poorly influenced by shear viscosity. This phenomenon allows independent recovery of the shear modulus and the viscosity, using, respectively, the dispersion curve and the attenuation estimation along the propagation axis.

Experimental and analytical parametric study of single-crystal unimorph beams for vibration energy harvesting

Abstract: This research presents an experimental and theoretical energy harvesting characterization of beam-like, uniform cross-section, unimorph structures employing single-crystal piezoelectrics. Different piezoelectric materials, substrates, and configurations are examined to identify the best design configuration for lightweight energy harvesting devices for low-power applications. Three types of piezoelectrics (single-crystal PMN-PZT, polycrystalline PZT-5A, and PZT-5H-type monolithic ceramics) are evaluated in a unimorph cantilevered beam configuration. The devices have been excited by harmonic base acceleration. All of the experimental characteristics have been used to validate an exact electromechanical model of the harvester. The study shows the optimum choice of substrate material for single-crystal piezoelectric energy harvesting. Comparison of energy scavengers with stainless steel substrates reveals that single-crystal harvesters produce superior power compared with polycrystalline devices. To further optimize the power harvesting, we study the relation between the thickness of the substrate and the power output for different substrate materials. The relation between power and substrate thickness profoundly varies among different substrate materials. The variation is understood by examining the change of mechanical transmissibility and the variations of the coupling figure of merit of the harvesters with thickness ratio. The investigation identifies the optimal thickness of the substrate for different substrate materials. The study also shows that the densities of the substrates and their mechanical damping coefficients have significant effects on the power output.

A 32 x 32 element row-column addressed capacitive micromachined ultrasonic transducer

Abstract: This paper presents characterization and initial imaging results of a 32 × 32 element two-dimensional capacitive micromachined ultrasonic transducer array. The devices are fabricated using a wafer bonding process in which both the insulation layer and the membrane are user-deposited silicon nitride. The transducers use a row-column addressing scheme to simplify the fabrication process and beamformer. By adjusting the number of rows and columns that are biased, the effective aperture of the transducer can be adjusted. This is significant because it permits imaging in the near-field of the transducer without the use of a lens. The effect on the transmit beam profile is demonstrated. The transducer has a center frequency of 5.9 MHz and a relative bandwidth of 110%. Images of horizontal and vertical wires are taken to demonstrate image resolution. A three-dimensional image of four pin heads is also demonstrated.

A flex-compressive-mode piezoelectric transducer for mechanical vibration/strain energy harvesting

Abstract: A piezoelectric transducer for harvesting energy from ambient mechanical vibrations/strains under pressure condition was developed. The proposed transducer was made of two ring-type piezoelectric stacks, one pair of bow-shaped elastic plates, and one shaft that pre-compresses them. This transducer works in flex-compressive (F-C) mode, which is different from a conventional flex-tensional (F-T) one, to transfer a transversely applied force F into an amplified longitudinal force N pressing against the two piezo-stacks via the two bow-shaped elastic plates, generating a large electric voltage output via piezoelectric effect. Our experimental results show that without an electric load, an F-C mode piezo-transducer could generate a maximum electric voltage output of up to 110 Vpp, and with an electric load of 40 kΩ, it a maximum power output of 14.6 mW under an acceleration excitation of 1 g peak-peak at the resonance frequency of 87 Hz.

Ultrasound-based radial and longitudinal strain estimation of the carotid artery: a feasibility study

Abstract: Ultrasound-based estimation of arterial wall elasticity is commonly used to assess arterial stiffness. However, previous elastography studies have mostly addressed radial strain measurements, and the longitudinal strain has been more or less ignored. This study shows the feasibility of a speckle-tracking-based algorithm for simultaneous estimation of radial and longitudinal strain in the carotid artery in silico. Additionally, these results were preliminarily confirmed in vivo.

Monitoring of thermal therapy based on shear modulus changes: I. shear wave thermometry

Abstract: The clinical applicability of high-intensity focused ultrasound (HIFU) for noninvasive therapy is today hampered by the lack of robust and real-time monitoring of tissue damage during treatment. The goal of this study is to show that the estimation of local tissue elasticity from shear wave imaging (SWI) can lead to the 2-D mapping of temperature changes during HIFU treatments. This new concept of shear wave thermometry is experimentally implemented here using conventional ultrasonic imaging probes. HIFU treatment and monitoring were, respectively, performed using a confocal setup consisting of a 2.5-MHz single-element transducer focused at 30 mm on ex vivo samples and an 8-MHz ultrasound diagnostic probe. Thermocouple measurements and ultrasound-based thermometry were used as a gold standard technique and were combined with SWI on the same device. The SWI sequences consisted of 2 successive shear waves induced at different lateral positions. Each wave was created using 100-μs pushing beams at 3 depths. The shear wave propagation was acquired at 17 000 frames/s, from which the elasticity map was recovered. HIFU sonications were interleaved with fast imaging acquisitions, allowing a duty cycle of more than 90%. Elasticity and temperature mapping was achieved every 3 s, leading to realtime monitoring of the treatment. Tissue stiffness was found to decrease in the focal zone for temperatures up to 43°C. Ultrasound-based temperature estimation was highly correlated to stiffness variation maps (r2 = 0.91 to 0.97). A reversible calibration phase of the changes of elasticity with temperature can be made locally using sighting shots. This calibration process allows for the derivation of temperature maps from shear wave imaging. Compared with conventional ultrasound-based approaches, shear wave thermometry is found to be much more robust to motion artifacts.