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JournalISSN: 1074-7613

Immunity

About: Immunity is an academic journal. The journal publishes majorly in the area(s): T cell & Immune system. It has an ISSN identifier of 1074-7613. Over the lifetime, 5462 publication(s) have been published receiving 1020299 citation(s).

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Topics: T cell, Immune system, Cytotoxic T cell ...read more
Papers
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Open accessJournal ArticleDOI: 10.1016/S1074-7613(00)80165-X
Albert Zlotnik, Osamu Yoshie1Institutions (1)
01 Feb 2000-Immunity
Topics: CCL7 (51%)

3,717 Citations


Open accessJournal ArticleDOI: 10.1016/J.IMMUNI.2006.01.001
01 Feb 2006-Immunity
Abstract: We describe de novo generation of IL-17-producing T cells from naive CD4 T cells, induced in cocultures of naive CD4 T cells and naturally occurring CD4+ CD25+ T cells (Treg) in the presence of TLR3, TLR4, or TLR9 stimuli. Treg can be substituted by TGFbeta1, which, together with the proinflammatory cytokine IL-6, supports the differentiation of IL-17-producing T cells, a process that is amplified by IL-1beta and TNFalpha. We could not detect a role for IL-23 in the differentiation of IL-17-producing T cells but confirmed its importance for their survival and expansion. Transcription factors GATA-3 and T-bet, as well as its target Hlx, are absent in IL-17-producing T cells, and they do not express the negative regulator for TGFbeta signaling, Smad7. Our data indicate that, in the presence of IL-6, TGFbeta1 subverts Th1 and Th2 differentiation for the generation of IL-17-producing T cells.

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Topics: IL-2 receptor (68%), Cytotoxic T cell (68%), Interleukin 21 (68%) ...read more

3,530 Citations


Open accessJournal ArticleDOI: 10.1016/J.IMMUNI.2014.06.008
17 Jul 2014-Immunity
Abstract: Description of macrophage activation is currently contentious and confusing. Like the biblical Tower of Babel, macrophage activation encompasses a panoply of descriptors used in different ways. The lack of consensus on how to define macrophage activation in experiments in vitro and in vivo impedes progress in multiple ways, including the fact that many researchers still consider there to be only two types of activated macrophages, often termed M1 and M2. Here, we describe a set of standards encompassing three principles—the source of macrophages, definition of the activators, and a consensus collection of markers to describe macrophage activation—with the goal of unifying experimental standards for diverse experimental scenarios. Collectively, we propose a common framework for macrophage-activation nomenclature.

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Topics: Macrophage polarization (53%)

3,340 Citations


Open accessJournal ArticleDOI: 10.1016/S1074-7613(00)80119-3
Osamu Takeuchi1, Katsuaki Hoshino1, Taro Kawai1, Hideki Sanjo1  +4 moreInstitutions (3)
01 Oct 1999-Immunity
Abstract: Toll-like receptor (TLR) 2 and TLR4 are implicated in the recognition of various bacterial cell wall components, such as lipopolysaccharide (LPS). To investigate in vivo roles of TLR2, we generated TLR2-deficient mice. In contrast to LPS unresponsiveness in TLR4-deficient mice, TLR2-deficient mice responded to LPS to the same extent as wild-type mice. TLR2-deficient macrophages were hyporesponsive to several Gram-positive bacterial cell walls as well as Staphylococcus aureus peptidoglycan. TLR4-deficient macrophages lacked the response to Gram-positive lipoteichoic acids. These results demonstrate that TLR2 and TLR4 recognize different bacterial cell wall components in vivo and TLR2 plays a major role in Gram-positive bacterial recognition.

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Topics: Gram-negative bacteria (58%), Peptidoglycan (57%), TLR4 (52%) ...read more

3,261 Citations


Open accessJournal ArticleDOI: 10.1016/S1074-7613(03)00174-2
01 Jul 2003-Immunity
Abstract: Peripheral blood monocytes are a heterogeneous population of circulating leukocytes. Using a murine adoptive transfer system to probe monocyte homing and differentiation in vivo, we identified two functional subsets among murine blood monocytes: a short-lived CX(3)CR1(lo)CCR2(+)Gr1(+) subset that is actively recruited to inflamed tissues and a CX(3)CR1(hi)CCR2(-)Gr1(-) subset characterized by CX(3)CR1-dependent recruitment to noninflamed tissues. Both subsets have the potential to differentiate into dendritic cells in vivo. The level of CX(3)CR1 expression also defines the two major human monocyte subsets, the CD14(+)CD16(-) and CD14(lo)CD16(+) monocytes, which share phenotype and homing potential with the mouse subsets. These findings raise the potential for novel therapeutic strategies in inflammatory diseases.

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Topics: Monocyte (56%), CD14 (55%), CD16 (50%)

3,100 Citations


Performance
Metrics
No. of papers from the Journal in previous years
YearPapers
2021239
2020233
2019248
2018249
2017241
2016296

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Journal's top 5 most impactful authors

Richard A. Flavell

43 papers, 11.7K citations

Florent Ginhoux

28 papers, 8.1K citations

Richard M. Locksley

19 papers, 3.7K citations

Frederick W. Alt

18 papers, 3.7K citations

Boris Reizis

16 papers, 3K citations

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