Showing papers in "Immunity in 1996"

TL;DR: It is demonstrated that, despite the existence of multiple signaling pathways activated by IL-4, Stat6 is essential for mediating responses toIL-4 lymphocytes.

TL;DR: It is shown that TRADD interacts strongly with RIP, another death domain protein that was shown previously to associate with Fas antigen, and is a serine-threonine kinase that is recruited by TRADD to TNFR1 in a TNF-dependent process.

TL;DR: A transgenic mouse model of HBV replication is used to demonstrate that adoptively transferred virus-specific CTLs can abolish HBV gene expression and replication in the liver without killing the hepatocytes.

TL;DR: It is indicated that IL-12 plays an essential role in regulating IFNγ production and in facilitating normal DTH responses and other phenomena associated with Th1 responses and cell-mediated immunity, i.e., IL-2 secretion and CTL generation, were not compromised in the absence of IL- 12.

TL;DR: In this article, the role of CD14 in bacterial-induced and LPS-induced shock was tested in CD14-deficient mice produced by gene targeting in embryonic stem cells.

TL;DR: Treatment of young TTP-deficient mice with antibodies to tumor necrosis factor alpha (TNF alpha) prevented the development of essentially all aspects of the phenotype, indicating a role for TTP in regulating TNF alpha synthesis, secretion, turnover, or action.

TL;DR: It is shown that the related chaperone, calreticulin, binds human class I-beta 2m dimers prior to peptide loading, suggesting that calretiulin remains associated with at least a subset of class I molecules when they, in turn, bind to TAP.

TL;DR: From the distribution of Ld on the target cells, it is suggested that a single peptide-MHC complex per target cell can trigger activation of the T cell cytolytic response.

TL;DR: It is demonstrated that two distinct signals, mitogenesis and anti-apoptosis, are required for gp130-induced cell growth and that STAT3 is involved in anti-APoptosis.

TL;DR: The lymphoid defects detected in Ikaros null mice reveal critical molecular differences between fetal and postnatal hematopoietic progenitors that dictate their ability to give rise to T cells and establish IkarOS as a tumor suppressor gene acting during thymocyte differentiation.

TL;DR: CD11b/CD18 plays a novel and unsuspected homeostatic role in inflammation by accelerating the programmed elimination of extravasated neutrophils.

TL;DR: The data imply that the inhibitory function of p58 is dependent on its tyrosine phosphorylation and on recruitment and activation of HCP, and that introduction of an inactive mutant HCP into an NK cell line prevented the p58-mediated inhibition of target cell lysis.

TL;DR: Mice deficient in interleukin-5 (IL-5-/- mice) were generated by gene targeting in embryonal stem cells, indicating that increased eosinophils do not play a significant role in the host defence in this parasite model.

TL;DR: Cycling and directional control of CTLA-4 expression may regulate its functional interaction with APCs bearing peptide-MHC complexes of appropriate specificity and avidity.

TL;DR: A novel accessory molecule, DNAX accessory molecule-1 (DNAM-1), that is constitutively expressed on the majority of peripheral blood T lymphocytes that participates in primary adhesion during cytotoxic T lymphocyte (CTL)-mediated cytotoxicity.

TL;DR: Purified cathepsin S specifically digested li from alpha beta li trimers, generating alpha beta-CLIP complexes capable of binding exogenously added peptide in vitro, and the formation of SDS-stable complexes was markedly reduced.

TL;DR: The results indicate an obligatory role of B cell complement receptors in responses of the B cells to protein antigens, and disrupted the Cr2 locus to generate mice deficient in both receptors.

TL;DR: The focus of this review has been on the complexity of biochemical events at a very proximal position in the TCR signaling cascade, focusing almost entirely on TCR-mediated signaling.

TL;DR: A role for the G-CSFR as a major regulator of granulopoiesis in vivo is confirmed and evidence is provided that G- CSFR-independent mechanisms of granutrophil survival must exist.

TL;DR: It is shown that mice with a null mutation in the NF-ATp gene have splenomegaly with hyperproliferation of both B and T cells and that it is important for the balanced transcription of the IL-4 gene during the course of an immune response.

TL;DR: A prominent role for FcγRIII in inflammatory and anaphylactic responses is indicated, making this receptor a potential target in immunotherapy.

TL;DR: The results suggest that the biological effects of peptide antagonists and partial agonists may be largely based on kinetic parameters, largely due to an increased off-rate.

TL;DR: Activation of CD22-deficient B lymphocytes by prolonged IgM cross-linking resulted in modest B cell proliferation, demonstrating that CD22 positively regulates antigen receptor signaling in the presence of antigen.

TL;DR: It is concluded that motile T cells are polarized antigen sensors that respond physically to [Ca2+]i signals to stabilize their interaction with APCs.

TL;DR: In B cell hybridomas from mice with this kappa transgene (P5'C), both the VJ region and the C region, but not the region between them, were mutated at similar frequencies, suggesting that the mutation mechanism is related to transcription.

TL;DR: In differentiating precursor B cells from all three strains of mice, the development of similar numbers of CD19+, CD23+, CD40+, and MHC class II+ expressing B lineage cells and similar levels of epsilon H chain gene transcription were induced.

TL;DR: The findings support the idea that the primordial function of macrophages may have been in tissue modeling and that their adapted role is in host defense.

TL;DR: This study demonstrates that the developmental characteristic most consistently associated with telomerase expression is self-renewal potential.