Showing papers in "Immunity in 2013"
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TL;DR: Emerging clinical data suggest that cancer immunotherapy is likely to become a key part of the clinical management of cancer and may be more effective in combination with agents that target other steps of the cycle.
4,351 citations
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TL;DR: The immune landscape in human colorectal cancer is revealed and the major hallmarks of the microenvironment associated with tumor progression and recurrence are revealed.
2,569 citations
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TL;DR: A fate-mapping study of the murine monocyte and macrophage compartment taking advantage of constitutive and conditional CX(3)CR1 promoter-driven Cre recombinase expression is reported, establishing that short-lived Ly6C(+) monocytes constitute obligatory steady-state precursors of blood-resident Ly 6C(-) cells and that the abundance of Ly6 C(+) blood monocytes dynamically controls the circulation lifespan of their progeny.
2,302 citations
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TL;DR: Results indicate that tissue-resident macrophages and circulating monocytes should be classified as mononuclear phagocyte lineages that are independently maintained in the steady state.
1,771 citations
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TL;DR: The key properties of IL-1 family members are reviewed, with emphasis on pathways of negative regulation and orchestration of innate and adaptive immunity.
1,545 citations
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TL;DR: A metabolic pathway whereby Trp metabolites from the microbiota balance mucosal reactivity in mice is described, whereby highly adaptive lactobacilli are expanded and produce an aryl hydrocarbon receptor (AhR) ligand-indole-3-aldehyde-that contributes to AhR-dependent Il22 transcription.
1,540 citations
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TL;DR: These results provide a unifying model for the activation of the NLRP3 inflammasome in which a drop in cytosolic K⁺ is the common step that is necessary and sufficient for caspase-1 activation.
1,498 citations
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TL;DR: This area will be the subject of this review, given that metabolic commitment is influenced not only by substrate availability but also by signaling pathways elicited by metabolites.
1,183 citations
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TL;DR: The physiological relevance of necroptosis and its role in the modulation of inflammation are discussed and apparently immunologically silent maintenance of T cell homeostasis is investigated.
1,081 citations
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TL;DR: Structural-guided mutation of the MLKL pseudoactive site resulted in constitutive, RIPK3-independent necroptosis, demonstrating that modification ofMLKL is essential for propagation of the ne croptosis pathway downstream of RIPK 3.
934 citations
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TL;DR: It is shown that mitochondrial metabolism in the absence of glucose metabolism is sufficient to support interleukin-2 (IL-2) induction and mitochondria are required for T cell activation to produce mROS for activation of nuclear factor of activated T cells (NFAT) and subsequent IL-2 induction.
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TL;DR: This review focuses on the molecular mechanisms and complex cellular actions of IL-2, its cooperative and opposing effects with other cytokines, and how both promoting and blocking the actions ofIL-2 are being utilized in clinical medicine.
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TL;DR: A human ILC1 subset that produced interferon-γ (IFN-γ) in response to IL-12 and IL-15 and had a unique integrin profile, intraepithelial location, hallmarks of TGF-β imprinting, and a memory-activated phenotype is characterized.
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TL;DR: Migratory CD11b(+) cDCs are identified as the principal subset inducing Th2 cell-mediated immunity in the LN, whereas moDCs orchestrate allergic inflammation in the lung.
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TL;DR: In normal individuals a subpopulation of circulating memory PD-1⁺CXCR5⁺CD4⁺ T cells that are resting memory cells most related to bona fide GC Tfh cells are identified that correlated with the development of bnAbs against HIV in a large cohort of HIV⁺ individuals.
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TL;DR: The capacity of both conventional and targeted anticancer therapies to enhance the immunogenic properties of malignant cells and to stimulate immune effector cells, either directly or by subverting the immunosuppressive circuitries that preclude antitumor immune responses in cancer patients are discussed.
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TL;DR: The demonstration of mouse and human DC subsets specialized in driving IL-17 responses highlights the conservation of key immune functions across species and will facilitate the translation of mouse in vivo findings to advance DC-based clinical therapies.
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TL;DR: A broader immunological interpretation of these three concepts--immune contexture, Immunoscore, and immunologic constant of rejection--that segregates oncogenic processes independently of their tissue origin is proposed.
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TL;DR: A unique analysis of human T cells in lymphoid and mucosal tissues obtained from individual organ donors is presented, revealing tissue-intrinsic compartmentalization of naive, effector, and memory subsets conserved between diverse individuals.
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TL;DR: Recent advances in the molecular understanding of cytosolic nucleic acid detection and its evasion by viruses are detailed.
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TL;DR: Although protection of males did not correlate with blood androgen concentration, hormone-supported expansion of selected microbial lineages may work as a positive-feedback mechanism contributing to the sexual dimorphism of autoimmune diseases.
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TL;DR: The immunological basis for therapeutic cancer vaccines and how the current understanding of dendritic cell and T cell biology might enable the development of next-generation curative therapies for individuals with cancer are discussed.
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TL;DR: The integration of the spleen in the regulation of immune responses locally and in the whole body is discussed and the relevance of findings for the understanding of inflammatory and degenerative diseases and their treatments is presented.
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TL;DR: Progress is described in understanding signaling mechanisms activated by DNA and the relevance of DNA sensing to pathogen responses and autoimmunity and new insights are highlighted into how and why the immune system responds to both pathogen and self DNA.
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TL;DR: Together these data suggest that mitochondria play a critical role in the activation of the Nlrp3 inflammasome through the direct binding of NLRp3 to cardiolipin.
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TL;DR: It is shown that Ly-6C⁺ monocytes constitutively trafficked into skin, lung, and lymph nodes (LNs) and can enter steady-state nonlymphoid organs and recirculate to LNs without differentiation to macrophages or DCs, revising a long-held view that monocytes become tissue-resident macrophage by default.
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TL;DR: A high degree of functional specialization occurs among the mononuclear phagocytes of the skin when monocyte-derived DCs are continuously generated by extravasated Ly-6C(hi) monocytes.
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TL;DR: Understanding how epigenetic alterations and Foxp3 expression coordinately control Treg-cell-specific gene regulation will enable better control of immune responses by targeting the generation and maintenance of Treg cells.
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TL;DR: It is likely that knowledge gained on how inflammation affects health in HIV disease could have implications for the understanding of other chronic inflammatory diseases and the biology of aging.
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TL;DR: Current experimental and clinical knowledge of the pathogenesis of atherosclerosis is reviewed through an immunological lens and how host defense mechanisms essential for survival of the species actually contribute to this chronic disease but also present new opportunities for its mitigation.