Showing papers in "Immunopharmacology and Immunotoxicology in 1981"
TL;DR: The effect of cobra venom factor on the developing and the established lesion of collagen-induced rat polyarthritis has been examined and results in a delay in the onset of inflammation and a decrease in the radiological parameters of joint destruction.
Abstract: The effect of cobra venom factor on the developing and the established lesion of collagen-induced rat polyarthritis has been examined. In the developing lesion, decomplementation by cobra venom factor results in a delay in the onset of inflammation and a decrease in the radiological parameters of joint destruction. Under the conditions of the decomplementation, antibody titers to collagen are not decreased. In the established lesion, treatment with cobra venom factor has no effect, on either the inflammatory lesion or the various radiological parameters of joint destruction.
33 citations
TL;DR: There was no correlation within this group of 40 individuals between three measures of immune function (absolute lymphocyte count, delayed hypersensitivity testing, and response to phytohemagglutinin) and the antibody response to the pneumococcal vaccine.
Abstract: We investigated whether indomethacin administration would augment the antibody response to pneumococcal vaccine in a group of healthy elderly individuals. There was no significant difference in mean increases in antibody levels to 12 pneumococcal polysaccharide types between the 20 subjects who received indomethacin 25 mg q.i.d. for five days after immunization and the control subjects not receiving indomethacin. In addition, there was no correlation within this group of 40 individuals between three measures of immune function (absolute lymphocyte count, delayed hypersensitivity testing, and response to phytohemagglutinin) and the antibody response to the pneumococcal vaccine.
7 citations
TL;DR: It is suggested that the present findings would contribute to elucidate the mechanism underlying antitumor synergistic effects between host's responses and treatment with antineoplastic agents.
Abstract: Mouse T-lymphocytes carrying the H-2?d haplotype were sensitized in vitro? against allogeneic spleen cells homozygous for the H-2?b haplotype. Cytolytic T-lymphocytes (CTL) were tested in a 4 hr cytotoxicity assay against 51Cr-labeled H-2?b RBL-5 lymphoma cells. The cytotoxic activity of CTL was markedly increased by preincubation with Ara-C (1 through 1000 μg/ml, 1 hr at 37°C). Limited but significant increase of cytotoxicity occurred when the drug was added to the effector-target mixture, or when target cells were preincubated with Ara-C using the same conditions adopted for the in vitro ?treatment of CTL. It is suggested that the present findings would contribute to elucidate the mechanism underlying anti-tumor synergistic effects between host’s responses and treatment with antineoplastic agents.
2 citations