Showing papers in "Immunopharmacology and Immunotoxicology in 1983"

Effect of corticosteroids on neutrophil function: inhibition of antibody-dependent cell mediated cytotoxicity (ADCC).

Abstract: Hydrocortisone sodium succinate (HC) inhibited “in vitro” neutrophil-mediated abtibody-depndent cellular cytotoxicity (ADCC). The drug effect was dose-depedent and completely reversible. The killing defect was partially overcome by increasing the density of the antibody on the target cells. However, HC added after the binding between effector and target cells was still able to inhibit in a similar dos-dependent way the cytotoxic activity. Gur results suggest that HC interferes in a later step, after the effector/target interaction. Methyl-prednisolone and dexamethasone as well as HC were found to inhibit in a dose-dependent manner the neutrophil-mediated ADCC, whereas testosterone did not have any effect.

Interferon as an in vitro modifier of immune responses induced by combined vaccine (DTP) in mice.

Abstract: The ability of DTP (diphtheria, tetanus, pertussis) vaccine to stimulate IgG-plaque forming cells (PFC) in mice was markedly inhibited by human leukocyte and mouse fibroblast interferon (IF) This effect of IF was not dose-dependent The maximum inhibitory effect of human IF was observed on Day 10 after the administration of the vaccine The inhibition of IgM-PFC was more severe when human IF was used Although IF abrogated the effect of DTP vaccine on IgG-PFC, at the same time it stimulated PFC in the control group of non-vaccinated animals The administration of DTP vaccine decreased IgM-PFC on Day 5, the effect was enforced by the addition of both human and mouse IF IF decreased IgM-PFC in the control group Small and large doses of DTP suppressed the leukocyte adherance inhibition (LAI) on Day 5 after administration of the vaccine, the effect was not affected by addition of IF The suppressive effect of DTP was lost on Day 10 when addition of IF increased the percent of LAI in all experimental groups Thus IF appears to interfere with the effect of DTP and selectively modulate the different immune responses