Indian Journal of Dermatology, Venereology and Leprology 

About: Indian Journal of Dermatology, Venereology and Leprology is an academic journal published by Medknow. The journal publishes majorly in the area(s): Medicine & Vitiligo. It has an ISSN identifier of 0378-6323. It is also open access. Over the lifetime, 5422 publications have been published receiving 48474 citations. The journal is also known as: Indian Journal of Dermatology Venereology and Leprology.

Association of HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome among Indians.

Abstract: Background: Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis are severe cutaneous reactions caused by certain drugs, including antiepileptic carbamazepine. A strong association has been reported between human leucocyte antigen (HLA)-B*1502 and carbamazepine-induced SJS in Han Chinese patients. European studies suggested that HLA-B*1502 is not a universal marker but is ethnicity-specific for Asians. Aim: To study the association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients. Methods: Eight individuals who fulfilled the diagnostic criteria of SJS induced by carbamazepine were identified and HLA-B molecular typing was performed. HLA-B genotyping was carried out by polymerase chain reaction using sequence-specific primers. Results: Out of eight patients studied for genotype, six patients were found to have the HLA-B*1502 allele. Conclusion: This study suggests an association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients.

Fitzpatrick skin typing: Applications in dermatology

Abstract: Fitzpatrick skin phototypes were developed by Thomas B. Fitzpatrick in 1975 based on a person’s skin color and responses to sun exposure in terms of degree of burning and tanning. Though subjective, Fitzpatrick skin typing has a proven diagnostic and therapeutic value. It has been most commonly used to analyze the sun sensitivity in population-based and case-control studies related to cause of skin cancer, exposure to UV radiation, tanning, and protective behaviors.[1,2] The Fitzpatrick scale has been applied as a standard for self-assessment of sun sensitivity in self-administered questionnaires and has been shown to correlate well for white skin as compared to brown skin.[3] Skin phototype typing is widely used for estimating UV, PUVA, and laser treatment doses.

Vitiligo: compendium of clinico-epidemiological features.

Abstract: Vitiligo, an autoimmune disorder characterized by localized and / or generalized depigmentation of the skin and / or mucous membranes, is a well-recognized entity. The imperatives of its epidemiology both in rural India and in global reckoning have been highlighted frequently. Its morphology is striking and is characterized by asymptomatic ivory / chalky white macule(s) that may be frequently surrounded by a prominent pigmented border, the 'trichrome vitiligo'. However vitiligo may have morphological variations in the form of: trichrome, quadri-chrome, penta-chrome, blue and inflammatory vitiligo. Its current topographical classification into segmental, zosteriform and nonsegmental, areata, vulgaris, acrofacialis and mucosal represent its well acclaimed presentations. Its adult and childhood onset is well appreciated as also its presentation in males and females. Occasionally, it may be possible to identify triggering factors. Vitiligo may be associated with cutaneous, ocular and systemic disorders, the details of which are discussed in this article.