Showing papers in "Indian Journal of Experimental Biology in 1974"

Chemical occlusion of Rhesus Monkey oviducts with quinacrine.

Abstract: Different doses of quinacrine in agar solution were instilled into the Fallopian tubes of healthy adult female rhesus monkeys in order to determine its effectiveness in producing tubal occlusion. The concentrations tested were 1% 10% 80% and 100%. The animals were sacrificed and checked for tubal blockade and histological changes at 7 15 30 60 and 100 days after treatment. Tubal blockade was noted at each time interval in all animals treated with 80% or 100% quinacrine.(AUTHORS MODIFIED)

Studies on the ultrastructure of the Fallopian tube: Part I. Changes in the ciliated cells of the rabbit Fallopian tube during ovum transport.

Abstract: The ultrastructural changes that occur in the ciliated cells of the tubal epithelium of the adult rabbit during ovum transport were previously reported. In this communication the changes that occur in the secretory cells of the tube under identical conditions are described. Estrous and pregnant rabbits were used. 14-70 hours postcoitum the size and shape of the microvilli of the ampullar cells differed from the isthmic ones. The prominence of the microvilli was roughly correlated with the possible arrival of the ovum in any part of the tube. The secretory granules in the cells of the ampulla were more electron dense than those in the isthmus. With the progress of the post ovulatory period the secretory granules changed in nature and location. During the postovulatory period the secretory process in both parts of the tube indicate a "merocrine" type of secretion. A cilium was occasionally present in the luminal epithelium of a secretory cell. Hybrid cells may arise when a cell malfunctions while receiving a set of messages from the nucleus at the time appropriate for cell differentiation.

Clinical toxicity study of Semecarpus anacardium Linn. f.

Abstract: Semecarpus anacardium was administered to 266 cases in 3 formulations: Amrit Bhallatak (186 cases) RB 3 (48 cases) and Garsin (32 cases). The Amrit Bhallatak is a compound formulation containing extract of both the cotyledons and the pericarp of the fruit of Semecarpus anacardium. RB3 is composed of the whole cotyledon (300 mg); the daily dose of cotyledons was 3.6 g. Garsin contained 200 g of cotyledons. The extract is derived by separating the oil by a physical process. The daily dosage of Amrit Bhallatak was 10 g/day that of Garsin 2.4 g/day. No toxicity or side effects were observed. The therapeutic value of Semecarpus anacardium in arthropathies atopic dermatitis leucoderma leprosy hypothyroidism oligospermia and azoospermia and its value as an oral contraceptive have been studied. The most significant effect was on the ovaries and testes. The drug probably acts via the hypophysics. Out of 266 patients 189 were men 77 women between 30-45 years of age. The treatment was restricted to internal medication by mouth. No external contact or application of the drug was applied. Of the 77 women treated with the drug 41 were followed up after treatment. 12 had become pregnant and none showed any teratogenecity.