Journal•ISSN: 1073-9149
Instrumentation Science & Technology
Taylor & Francis
About: Instrumentation Science & Technology is an academic journal published by Taylor & Francis. The journal publishes majorly in the area(s): Mass spectrometry & Spectrometer. It has an ISSN identifier of 1073-9149. Over the lifetime, 1718 publications have been published receiving 11781 citations. The journal is also known as: Instrumentation science and technology.
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TL;DR: In this paper, a microcalorimeter for measuring thermal effects has been constructed using computer control and the enthalpy of solution in water of the complex Zn(Val)SO4·H2O was determined at 298.15 K with this instrument.
Abstract: A new microcalorimeter for measuring thermal effects has been constructed. It is a totally automatic instrument utilizing computer control. The baseline stability, sensitivity, accuracy, and precision of the instrument are obtained from direct measurements. The enthalpy of solution in water of the complex Zn(Val)SO4·H2O was determined at 298.15 K with this instrument.
157 citations
TL;DR: In this paper, the authors present the development and current state of a small-angle X-ray scattering station at beamline 1W2A of the Beijing Synchrotron Radiation Facility, China.
Abstract: This article presents the development and current state of a small-angle X-ray scattering station at beamline 1W2A of the Beijing Synchrotron Radiation Facility, China. The source of the beamline is introduced from a 14-pole wiggler. A triangular bending Si(111) crystal is used to horizontally focus the beam and provide a monochromatic X-ray beam (8.052 keV). A bending cylindrical mirror coated with rhodium downstream from the monochromator is used to vertically focus the beam. The X-ray beam is focused on the detector which is fixed at 30 m from the source. The focused beam size (full width at half maximum) is 1.4 × 0.2 mm2 (horizontal × vertical) with a flux of 5.5 × 1011 phs/s at 2.5 GeV and 250 mA. Besides the routine mode of small-angle X-ray scattering, the combination of small- and wide-angle X-ray scattering, grazing incidence small-angle X-ray scattering, and time-resolved small-angle X-ray scattering in sub-second level are also available for the users. Dependent on the measurement requirements,...
152 citations
TL;DR: In this paper, a method for simultaneous analysis of multiple total intensity, anisotropy, and excited-state reactions is proposed for both anisotropic and excited state reaction data.
Abstract: Methodologies for the simultaneous analysis of multiple total-intensity, anisotropy, and excited-state reactions are developed. Alternatives to the standard sums-of-exponentials fitting are proposed for both anisotropy and excited-state reaction data. Both simulation studies and real-data examples show these methods to be superior to single curve analysis.
127 citations
TL;DR: In this article, the authors describe the construction and operation of a cross-correlation phase and modulation fluorometer which uses the harmonic content of a high repetition rate mode-locked laser as the excitation source.
Abstract: We describe the construction and operation of a cross-correlation phase and modulation fluorometer which uses the harmonic content of a high repetition rate mode-locked laser as the excitation source. A mode-locked argon ion laser is used to synchronously pump a dye laser. The pulse train output from the dye laser is amplitude modulated by an acousto-optic modulator and then frequency doubled with an angle tuned frequency doubler. With the particular dye utilized in these studies, the ultraviolet light obtained was continuously tunable over the range 280-310 nm. In the frequency domain the high repetition rate pulsed source gives a large series of equally spaced harmonic frequencies. The frequency spacing of the harmonics is determined by the repetition frequency of the laser. Amplitude modulation of the pulse train permits variation of the frequency quasi-continuously from a few hertz to gigahertz. Use of cross-correlation techniques permits precise isolation of individual frequencies. The cross...
123 citations
TL;DR: A global strategy aimed at extending the breadth and throughput of proteomic measurements based on utilizing polypeptide “accurate mass tags” produced by global protein enzymatic digestion provides greater confidence in the assignment of protein identifications than possible with conventional tandem mass spectrometric data alone.
Abstract: We review a global strategy aimed at extending the breadth and throughput of proteomic measurements based on utilizing polypeptide “accurate mass tags” produced by global protein enzymatic digestion. The two-stage strategy described employs conventional mass spectrometric techniques to provide initial putative identifications of peptides based on searching genome databases using the partial sequence information gleaned from tandem mass spectrometric data. The second stage of the strategy utilizes advanced mass spectrometric instrumentation to “validate” those putative identifications initially made using conventional tandem mass spectrometric data. Specifically, the high mass accuracy provided by more advanced instrumentation is utilized and ultimately correlated with the conventional tandem mass spectrometric data (along with each of the peptides' liquid chromatographic elution time) to validate the putative identifications. The strategy described provides greater confidence in the assignment of...
112 citations