Abstract: In this article, entropy generation on MHD nanofluid towards a stagnation point flow over a permeable stretching surface has been investigated numerically. The governing equations of nanofluid are simplified using similarity variables with the help of momentum, energy and concentration equations. The resulting highly nonlinear coupled differential equations are solved with the help of successive linearization method and Chebyshev spectral collocation method. The impact of all the pertinent parameters such as Hartmann number, suction/injection parameter, heat source/sink parameter, Lewis number, Prandtl number, Brownian motion parameter, thermophoresis parameter are demonstrated graphically. Furthermore, the effect of Brinkman number and Reynolds number are also presented for entropy generation. It is analyzed that the velocity of the fluid increases due to greater influence of magnetic field and porosity parameter. Moreover, it is also observed that the entropy generation number increase due to the increment in Brinkman number and Reynolds number. Numerical comparison is also given with the existing published literature and found that the present results are in good agreement.