Showing papers in "International Journal of Cardiology in 2016"

TL;DR: This review describes the enzymatic pathways involved in the degradation of purines, getting into their structure and biochemistry until the uric acid formation.

TL;DR: Young female patients with SCAD represent a high-risk subgroup of patients with AMI and require close follow-up, and Kaplan-Meier analysis showed a significantly higher incidence of MACE in the SCAD group compared to the no-SCAD group.

TL;DR: LAA occlusion is a reasonable alternative to chronic warfarin therapy in stroke prevention for patients with atrial fibrillation and the safety of the device has improved compared to previous trials.

TL;DR: Results clearly show that participation in CR programs follows a determined pattern that is very homogeneous in different settings, and health professionals should also be aware of patients reluctant to participate inCR programs and adapt their messages and redesign CR programs, to promote participation and adherence.

TL;DR: Combined exosome-ADMSC therapy was superior to either one for protecting kidney from acute IR injury and showed an opposite pattern of creatinine level among the five groups.

TL;DR: The pattern and global burden of disease has evolved considerably over the last two decades, from primarily communicable, maternal, and perinatal causes to non-communicable disease (NCD), but CVD remains one of the greatest health challenges both nationally and worldwide.

TL;DR: Serum uric acid is associated with increased risk for incident coronary heart disease, heart failure, and atrial fibrillation, and in the setting of established systolic heart failure is positively associated with disease severity and mortality risk.

TL;DR: In this article, the Nod-like Receptor Protein-3 (NLRP3) inflammasome was used to inhibit the inflammatory component of the reperfusion injury.

TL;DR: Sarcopenia affects a clinically relevant proportion of patients with HFpEF and is strongly linked to reduced muscle strength, exercise capacity and QoL in these patients.

TL;DR: All-cause mortality is significantly higher in AF patients with HFrEF compared to HFpEF, although stroke risk and heart failure hospitalization are similar, and further studies are needed to address the prevention of adverse outcomes in allAF patients with heart failure, regardless of ejection fraction.

TL;DR: Cause of death of ACHD patients in a large contemporary cohort from a national register are in the majority still CHD-related, with heart failure being the leading cause of death, and extracardiac comorbidities gain increasing importance.

TL;DR: The present review article will try to summarize the most recent evidences on the efficacy of XO inhibitors and uricosuric compounds in lowering uric acid levels in both the bloodstream and peripheral tissues and focus on the effect of novel XO inhibitor in counteracting uric Acid overproduction.

TL;DR: Current evidence supports an association between genomic DNA methylation and CVD, however, this review highlights important gaps in the existing evidences including lack of large-scale epigenetic investigations, needed to reliably identify genomic loci whereDNA methylation is related to risk of CVD.

TL;DR: The aims of this article are to review the current complex issues associated with statin use and to explore when novel treatment approaches should be considered, including proprotein convertase subtilisin/kexin type 9 inhibitors should arguably be used more often in those patients in whom treatment with statins remains unsatisfactory.

TL;DR: It is demonstrated that decreased HGS and GS are associated with CVD mortality, with the association found to be more consistent for GS as compared to HGS.

TL;DR: Investigating whether achieving a greater number of ideal cardiovascular health metrics was associated with a lower risk of CVD and mortality in the general population by conducting a meta-analysis of data from available prospective cohort studies found it was so, supporting the use of cardiovascularhealth metrics as a useful tool to predict mortality and cardiovascular disease risk.

TL;DR: Imaging modality including echocardiogram, angio CT and cardiac MRI, and lab tests for catecholamine, troponin T, creatine kinase MB and B-type natriuretic peptide can be useful to differentiate TTC from other diseases.

TL;DR: The Australian and New Zealand population of patients alive after a Fontan procedure will double over the next 20years increasing the demand for heart-failure services and cardiac transplantation.

TL;DR: Algorithms based on diagnosis codes and prescription data could achieve moderate to high agreement in identifying the selected risk factors, whereas prescription data helped improve identification of hyperlipidemia.

TL;DR: It can be concluded that both heavy and light exercise may cause elevated troponin, which have to be considered when patient are suspected to have a myocardial infarction.

TL;DR: SIRT1 activation by interfering with fibrogenesis can improve relaxation properties of myocardium and attenuate myocardial remodeling related to chemotherapy and reveal a key role of SIRT1 in supporting animal survival and functional parameters of the heart.

TL;DR: Significant regional variability in socioeconomic and clinical factors, etiologies and treatments in HF patients from Africa, Asia, the Middle East and South America is described.

TL;DR: Recommendations for use of CMR in rheumatoid arthritis, the spondyloarthropathies, systemic lupus erythematosus, vasculitis of small, medium and large vessels, myositis, sarcoidosis, and scleroderma, and a research agenda for the further development of this evolving field are outlined.

TL;DR: Decreased SAL on admission, including levels within "normal" clinical range, is significantly associated with long-term all-cause mortality in hospital survivors of AMI with a "dose-response" type association.

TL;DR: Polypill therapy significantly improved adherence, SBP and LDL-cholesterol in high risk patients compared with usual care, especially among those who were under-treated at baseline.

TL;DR: A gap in the knowledge on the status of heart failure in Asia versus other regions led to the creation of a working group of Asian experts, and this review supports implementation of a more comprehensive and organized approach to HF care in Asia.

TL;DR: While influence of gender-specific hs-cTnT cut-offs on diagnostic and prognostic reclassification was only modest in patients with suspected AMI, age-specific cut-off showed a significant impact and may be considered for further validation.

TL;DR: The impact of anaemia on reduced exercise capacity and on mortality is stronger than that of ID, and Anaemia remained an independent predictor of death after adjusting for clinically relevant variables.

TL;DR: The main features of LA strain are described and the role of STE in the evaluation of various aspects of AF, as the risk of developing the arrhythmia in general population, the Evaluation of LA fibrosis and LA impairment, the quantification of cardioembolic risk and of recurrence after cardioversion or ablation therapies are examined.