International Journal of Dermatology and Venereology 

About: International Journal of Dermatology and Venereology is an academic journal published by Chinese Medical Association. The journal publishes majorly in the area(s): Vitiligo & Psoriasis. It has an ISSN identifier of 1673-4173. Over the lifetime, 267 publications have been published receiving 5034 citations.

人唾液天疱疮抗原的纯化

Abstract: 1. Place animal in induction chamber and anesthetize the mouse and ensure sedation. 2. Once the animal is sedated, move it to a nose cone for hair removal using cream. Only apply cream to the area of the chest that will be utilized for imaging. Once the hair is removed, wipe area with wet gauze to ensure all hair is removed. 3. Move the animal to the imaging platform and tape its paws to the ECG lead plates and insert rectal probe. Body temperature should be maintained at 36-37°C. During imaging, reduce anesthesia to maintain proper heart rate. If the animal shows signs of being awake, use a higher concentration of anesthetic.

Dyskeratosis congenita

Abstract: 先天性角化不良是一种少见的先天遗传性皮肤病,其临床三联征包括:甲板营养不良,口腔或阴道等可出现白斑,皮肤异色症样的色素沉着.先天性角化不良是与编码角化不良蛋白基因、编码端粒酶的RNA组份基因、编码端粒酶的逆转录酶基因突变及其他未确认的致病基因突变引起的基因病,其遗传方式有:X-性联隐性遗传、常染色体显性遗传及常染色体隐性遗传.治疗上还缺乏有效的治疗方法.文中从先天性角化不良的发病机制、突变类型、临床表型以及治疗方面综述先天性角化不良的研究进展。

Advances in H1-antihistamines

Abstract: There are four major types of histamine receptor,H1,H2,H3 and H4 in human body. Histamine plays its biologic role primarily through its receptors. At present,H1-antihistamines are mainly used to treat urticaria and other allergic diseases as well as central nervous system and vestibular disorders. There has never been standardized studies on the application of first-generation H1-antihistamines in the treatment of allergic diseases, and most clinical trials of these drugs do not meet the standards for randomized, double-blind,placebo-controlled trial (RCT). In contrast, the second-generation drugs are supported by large number of normative trials. Clinically, most H1-antihistamines are safe and effective, but the side effects on central nervous system and the heart should not be ignored.