International Journal of Drug Development and Research 

About: International Journal of Drug Development and Research is an academic journal. The journal publishes majorly in the area(s): Drug delivery & DPPH. It has an ISSN identifier of 0975-9344. Over the lifetime, 865 publications have been published receiving 5650 citations.

Buccal Mucosa as A Route for Systemic Drug Delivery: A Review

Abstract: Within the oral mucosal cavity, the buccal region offers an attractive route of administration for systemic drug delivery. The mucosa has a rich blood supply and it is relatively permeable. It is the objective of this article to review buccal drug delivery by discussing the structure and environment of the oral mucosa and the experimental methods used in assessing buccal drug permeation/absorption. Buccal dosage forms will also be reviewed with an emphasis on bioadhesive polymeric based delivery systems

Hydrotropy: a promising tool for solubility enhancement: a review

Abstract: The study on solubility yields information about the structure and intermolecular forces of drugs. Use of the solubility characteristics in bioavailability, pharmacological action and solubility enhancement of various poorly soluble compounds is a challenging task for researchers and pharmaceutical scientists. Hydrotropy is one of the solubility enhancement techniques which enhance solubility to many folds with use of hydrotropes like sodium benzoate, sodium citrate, urea, niacinamide etc. and have many advantages like; it does not require chemical modification of hydrophobic drugs, use of organic solvents, or preparation of emulsion system etc.

Protective effect of Solanum torvum on Doxorubicin- induced hepatotoxicity in rats

Abstract: Hepatotoxicity is one of the main side effects associated with Doxorubicin (DOX) treatment. The aim of the present study was to examine the protective effect of S. torvum in Doxorubicin (DOX) induced hepatotoxicity. Wistar rats received either DOX (67.75 mg/kg, i.v, 2 days before sacrifice) or Solanum torvum (100 mg/kg and 300 mg/kg, p.o.) prior to DOX or S. torvum (100 mg/kg and 300 mg/kg, p.o.) extract alone for 4 weeks. Hepatotoxicity was assessed in rats by recording changes in biochemical and histopathological approaches. Abnormal levels of transaminases (ALT and AST) in blood and the antioxidant defence enzymes superoxide dismutase (SOD) and catalase (CAT) for liver were measured at the end of the treatment schedule. Treatment with S. torvum (100 mg/kg and 300 mg/kg) significantly (p<0.05) decreased the levels of ALT, AST, and increased the anti-oxidant defence enzyme levels of SOD and CAT. Histopathological changes showed that DOX caused significant structural damages to liver like inflammation, congestion and necrosis which was reversed with S. torvum. The results suggest that S. torvum has the potential in preventing the organ toxicity induced by Doxorubicin.

FAST DISSOLVING FILMS (FDFs) AS A NEWER VENTURE IN FASTDISSOLVING DOSAGE FORMS

Abstract: Fast-dissolving oral delivery systems are solid dosage forms, which disintegrate or dissolve within 1 min when placed in the mouth without drinking water or chewing. More recently, fast-dissolving films are gaining interest as an alternative to fast-dissolving tablets to definitely eliminate patient?s fear of chocking and overcome patent impediments. Fast-dissolving films are generally constituted of plasticized hydrocolloids or blends made of thereof that can be laminated by solvent casting or hot-melt extrusion. Thin film drug delivery, also referred to as orally dissolving thin film, and has emerged as an advanced alternative to the traditional tablets, capsules and liquids often associated with prescription and OTC medications. Similar in size, shape and thickness to a postage stamp, thin film strips are typically designed for oral administration, with the person placing the strip on or under the tongue or along the inside of the cheek. Thin film enables the drug to be delivered to the blood stream either intragastrically, buccally or sublingually. The sublingual and buccal delivery of a drug via thin film has the potential to improve the onset of action, lower the dosing, and enhance the efficacy and safety profile of the medicament. The 2-year-old, melt-in-your-mouth delivery system certainly has gained traction among consumers since the 2001 introduction of Pfizer’s Listerine Pocket Packs. And now many OTC suppliers are banking on that consumer acceptance as they try to leverage the thin strip technology against a new generation of self-care remedies. There are currently several projects in development that will deliver prescription drugs utilizing the thin film dosage form.

Coplanarity and Collinearity of 4-Dinonyl-2,2âBithiazole in One Domain of Bleomycin and Pingyangmycin to be Responsible for Binding of Cadmium Oxide (CdO) Nanoparticles to DNA/RNA Bidentate Ligands as Anti-Tumor Nano Drug

Abstract: Volume 8(3): 001-002 (2016)-01 In human bodies the third abundant trace metal is Cadmium; it can be considered as a non–toxic metal [1-12]. In coordination and pharmaceutical biochemistry many studies are on the interaction of Cd (II) cations with biomolecules such as DNA, RNA and other nucleic acids. When there is coordination between the organic ligands such as DNA, RNA and other nucleic acids to Cd (II) cations, this makes biological, medical, pharmaceutical and biochemical properties of them improve or modify. To extend this matter a new complex of Cd (II) cations with ligands nucleic acids was designed and prepared. The complex was obtained from an aqueous–alcoholic solution. Single crystals of the title complex were obtained from a mixture of Cd (II) cations and nucleic acids after slowing evaporation at room temperature. The crystal structure of the complex was determined by Scanning Electron Microscope (SEM), Transmission Electron Microscope (TEM), Differential Thermal Analysis–Thermal Gravim Analysis (DTA– TGA), Energy–Dispersive X–Ray Spectroscopy (EDX) and X–Ray Diffraction (XRD) analysis, this showed the structure to be ionic. Cd (II) cations in this complex have approximately Ci symmetry. In complex, the Cadmium atom is four–coordinate in a distorted tetrahedral arrangement. The geometry of the metal coordination shows some deviations from ideal Td symmetry. There are some differences in bond lengths and angles in complex. The Cd (II) cations in complex which symmetrically independent and have some differences in their bond lengths and angles.