International Journal of Hematology and Oncology 

About: International Journal of Hematology and Oncology is an academic journal published by Akademi Doktolar Yayinevi. The journal publishes majorly in the area(s): Lung cancer & Cancer. It has an ISSN identifier of 1306-133X. It is also open access. Over the lifetime, 356 publications have been published receiving 914 citations.

Safety and Efficacy of Ankaferd Blood Stopper in Dental Surgery

Abstract: The aim of this study was to assess retrospectively the hemostatic efficacy and safety of the topical use of Ankaferd Blood Stopper (ABS) in the setting of dental surgery. Following the approval from of the Local Research Ethics Committee ABS as a hemostatic agent in Dentistry, ABS was topically applied by homogeneously spraying to the 25 patients during dental inter- ventions. Based on this retrospective evaluation; Tissue healing was evaluated at the 48th hour. The patients received 1 to 5 mL of ABS; the median dose was 2 mL. Bleeding stopped in median 1.8 seconds (1 to 3 seconds) in the first ABS appli- cation in 20 patients. Five patients needed a second dose of ABS; four of them were given 5 mL ABS totally. No patient had wound infection and the healing process appeared to be normal. ABS is useful for the local hemostasis and wound healing in periodontal surgeries.

Evaluation of Linear Accelerator (Linac)-Based Stereotactic Radiosurgery (Srs) for The Treatment of Craniopharyngiomas

Abstract: Although benign histologically, craniopharyngiomas may display clinically malignant behavior with a strong propensity for recurrence. Contemporary therapeutic approaches for craniopharyngiomas include stereotactic irradiation in the form of Stereotactic Radiosurgery (SRS) or Fractionated Stereotactic Radiation Therapy (FSRT) as part of multimodality treatment particularly when complete surgical removal is not feasible. In this study, we evaluate the use of Linear Accelerator (LINAC)-based SRS in the multidisciplinary management of patients with craniopharyngiomas. Between July 1998 and July 2013, 20 patients (11 male, 9 female) with residual or recurrent craniopharyngiomas were treated using LINAC-based SRS at Department of Radiation Oncology, Gulhane Military Medical Academy. Median age was 37 (9-69) years. Median tumor volume was 1.1 (0.9-6.9) cc. Median dose was 13 Gy (range: 10-16 Gy) prescribed to the 80%-95% isodose line encompassing the target volume. Median follow-up time was 47 (7-93) months. Overall local control rate was 88% at 1 year, 79% at 3 years and 66% at 5 years. Three and 5-year progression free survival rates were 95% and 91% whereras 3 and 5-year overall survival rates were 94% and 88%, respectively. Our study supports the usage of LINAC-based SRS as a safe and effective management strategy for patients with recurrent or residual craniopharyngiomas.

Protective Role of Royal Jelly Against Radiation- Induced Oxidative Stress in Rats

Abstract: The aim of this study was to investigate the effects of royal jelly against gamma-radiation induced oxidative damage in liver and lung tissue after total body irradiation. The adult male Sprague Dawley rats were randomly divided into six groups of sixteen animals each; group 1: control group (C), group 2: only irradiated rats (IR), group 3: irradiated rats with royal jelly administration at 25 mg/kg/day (IR+RJ25), group 4: irradiated rats with royal jelly administration at 50 mg/kg/day (IR+RJ50), group 5: only royal jelly administration at 25 mg/kg/day (RJ25), group 6: only royal jelly administration at 50 mg/kg/day (RJ50). Royal jelly (RJ) was administered at a dose of 25 and 50-mg/kg body weight, by gavage for 10 days prior to irradiation and 10 days after irradiation. On the tenth day of study, radiotherapy was applied to the whole-body by single fraction at a dose of 6 Gy. Half of rats were sacrificed at 24 hours and 10 days after irradiation under ether anesthesia. Blood samples were collected and analysed for alanine aminotransferase, aspartate aminotransferase, triygliceride, total cholesterol and gamma glutamyl transpeptidase levels. The lung and liver samples were stored for the measurement of malondialdehyde, glutathione peroxidase, superoxide dismutase and catalase activities. Rats exposed to wholebody irradiation induced a marked liver failure, characterized with a significant increase in serum AST, ALT, cholesterol and triglyceride concentrations, and also they had higher lung and liver MDA and lower GSH-Px, CAT and SOD (p<0.001). Administration of royal jelly resulted in a significant decreased in oxidative stress parameters and biochemical parameters, and certainly increased antioxidant activities. Furthermore, pre- and post-treatment with RJ was more effective than pre-treatment with RJ. These results suggest that royal jelly may probably protect the animals from radiation-induced liver and lung damage. The effects of

ABO and Rh Blood Groups Frequency in Denizli Province

Abstract: The history of the studies on blood groups dates back to early 20th century. Today, more than 600 antigenic structure was detected among 29 blood groups. However, ABO and Rh antigenic structure were taken into consideration in transfusion medicine. To know the rates of the blood groups in a city really helps the citizens in need and blood bank employees. There isn’t any study on frequency of blood groups in Denizli. In this study, we aimed to find out the rates of ABO and Rh blood groups in Denizli province and provide new data to the literature. This study is fulfilled by evaluation of 64.840 people, who were applied to Denizli State Hospital for identification of blood groups between January 2005 and August 2009. Blood groups were examined by gel-centrifugation method. In our study, 58.292 (89.9%) people were found Rh positive and 6548 (10.1%) people were found Rh negative. The frequency of the blood groups A, O, B, AB were found in order as 42.6%, 33.3%,16.8%, 7.4% respectively. The rates of blood groups in Denizli are similar throughout Turkey and in city basis. We consider that this study, which is the first in our city, will contribute to the literature.

Risk Factors for Cervical Cancer: Results from a Hospital-Based Case-Control Study

Abstract: The aim of this study was to investigate risk factors for cervical cancer in Turkish women. In a hospital-based case-control study in ‹stanbul, 209 patients with histologically confirmed cervical cancer were compared with 1050 controls, who were admitted to the different departments of the same hospital. Odds ratios (OR) and 95% confidence intervals (CI) were obtained from multivariate logistic regression analysis, fitted by the method of maximum likelihood. Risk factors for cervical cancer were found to be early age at first sexual intercourse (OR = 58.07, 95% CI: 27.88-120.95) and history of genital infection (OR = 5.17, 95% CI: 3.51-7.60). However, compared with controls, it was found that cases including higher education (OR = 0.18, 95% CI: 0.10-0.30), non-married (OR = 0.07, 95% CI: 0.04-0.12) and non-use of alcohol (OR = 0.30, 95% CI: 0.14-0.65) had a decreased risk for cervical cancer. Our results are supportive of the hypothesis that early age at first sexual intercourse and history of genital infection is related with the risk factors for cervical cancer. Therefore, monogamy, late commencement of sexual activity, personal hygiene and use of barrier contraceptive methods help towards primary prevention.