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Showing papers in "International Journal of Pharmaceutics in 1989"


Journal ArticleDOI
TL;DR: In this paper, an attempt was made to elucidate the mechanisms of formation in terms of interfacial turbulence between two unequilibrated liquid phases involving flow, diffusion and surface tension decrease (Marangoni effect).

2,017 citations


Journal ArticleDOI
TL;DR: In this paper, a coupled diffusion/relaxation model is presented for general analysis of the release behavior of controlled release systems using a coupled diffusional and relaxation model, and the general form of this equation's exponent is related to the geometric shape of the releasing device through its aspect ratio.

1,385 citations



Journal ArticleDOI
TL;DR: In this article, a computer method has been devised to describe the theoretical dissolution rate of a polydisperse powder under non-sink conditions based on its percent weight particle size distribution.

304 citations


Journal ArticleDOI
TL;DR: In vivo, the formation of the gel prolonged precorneal residence time and increased ocular bioavailability of timolol in the cornea, aqueous humor and iris + ciliary body of albino rabbits.

299 citations


Journal ArticleDOI
TL;DR: In this paper, a simple quantitative and realistic in situ method to test the bioadhesive potential of polymers was developed, in which the glass spheres or drug crystals were first coated with the polymers to be tested.

256 citations


Journal ArticleDOI
TL;DR: In this article, the authors developed and evaluated adhesive patches for buccal administration, consisting of two-ply laminates of an impermeable backing layer and a hydrocolloid polymer layer containing the drug.

181 citations


Journal ArticleDOI
TL;DR: Good to excellent muco-adhesive properties were detected in the HA preparations, and the bioavailability-enhancing effect was not very satisfactory with Pi, probably on account of the high solubility and diffusivity of the drug.

163 citations


Journal ArticleDOI
TL;DR: The addition of low molecular weight poly( dl -lactide) clearly accelerated the release of drug from both films and microspheres and allowed control over the drug release with a single, biodegradable homopolymer.

156 citations


Journal ArticleDOI
TL;DR: Neither the gastric emptying nor small intestine transit of the tablets was affected by their size, however, the nature of the meal consumed had a marked effect on gastrics emptying and the nature the meal also appeared to influence the transit through the ileocaecal sphincter.

152 citations


Journal ArticleDOI
TL;DR: In this article, the authors investigated the hydrolysis rate of phosphatidylcholine as a function of pH, temperature, buffer concentration and buffer species, and found that the rate increased with increasing concentration of buffer species.

Journal ArticleDOI
TL;DR: In this article, the effects of various classes of transmucosal and transdermal absorption promoters on buccal insulin absorption in rats were evaluated, using aqueous vehicles containing 5% adjuvant.

Journal ArticleDOI
TL;DR: A method for the determination of in vitro release of hydrocortisone from creams using Franz diffusion cell system and synthetic membranes has been developed and can be employed as a quality control procedure for assuring batch-to-batch uniformity of topical products.

Journal ArticleDOI
TL;DR: In this article, the interfacial works of cohesion and adhesion between substrate and binder, in addition to the spreading coefficients of one phase on the other have been calculated for a number of pharmaceutical solids and polymeric binders using literature values of surface free energies and polarities.

Journal ArticleDOI
TL;DR: In this article, a spray-drying technique was used to prepare the amorphous state of drug inclusion complexes with β-cyclodextrin and X-ray diffractometry, differential scanning calorimetry and IR spectroscopy.

Journal ArticleDOI
TL;DR: With the finite dose technique, PG pretreatment increased drug penetration, contrasting with its ineffectiveness in the previous steady-state work.

Journal ArticleDOI
TL;DR: In this paper, three native starches, varying in their amylose/amylopectin content were pregelatinized by extrusion, drum-drying and a controlled pre-gelatinization-spraydrying technique to produce cold water-swellable starches.

Journal ArticleDOI
TL;DR: In this paper, essential oils were evaluated as penetration enhancers towards 5fluorouracil using excised human skin and Eucalyptus and Chenopodium were found to be very effective, causing a near 30-fold increase in the drug permeability coefficient.

Journal ArticleDOI
TL;DR: It is demonstrated that in most cases the results obtained are in fact independent of the release rate, and that the observed release rate is solely dependent on the partition coefficient of the drug between the colloid and its continuous phase.

Journal ArticleDOI
TL;DR: The effect of curcumin on the production of hydroxyl radicals through the Fenton reaction has been studied in this article, where it was shown that the curcurumin can reduce ferric ion to ferrous and this ferrous ion can generate a hydrastic radical in the presence of hydrogen peroxide.

Journal ArticleDOI
TL;DR: Tissue viability and integrity, the two important membrane properties involved in the overall transport process, were investigated and the mechanisms and the significance of membrane pennselectivity to epithelial drug transport are discussed.

Journal ArticleDOI
TL;DR: In this paper, the thermal behavior of human stratum corneum is investigated using Nalkyl-azacycloheptan-2-one with a varying number of carbon atoms in the alkyl chain.

Journal ArticleDOI
TL;DR: In this article, the existence of microemulsion regions was investigated in quaternary systems composed of Brij 96 by constructing phase diagrams, and the diameter of the internal phase was determined as a function of the surfactant:cosurfactant ratio at a constant internal phase/oil ratio.

Journal ArticleDOI
TL;DR: The presence of food markedly altered the pharmacokinetics of the drug which, in fasting subjects, was characterised by a double peak in the plasma concentration time profile which appears to be due to a disintegration of the matrix after 12–14 h coupled with a high absorptive capacity for the drug in the ascending colon.

Journal ArticleDOI
TL;DR: In this article, an innovative, injectable, submicronized emulsion delivery system into which diazepam was incorporated has been developed using a high shear mixer followed by a two stage pressure homogenizer yielding a very fine monodispersed emulsion.

Journal ArticleDOI
TL;DR: In this paper, the LKB 2277 thermal activity monitor (TAM) is used to measure the rate of heat production from a sample (i.e., arising from a chemical reaction) with a sensitivity of about 104 greater than is possible with a conventional differential scanning calorimeter.


Journal ArticleDOI
TL;DR: In this paper, the phase separation of different poly(d,l -lactic acid-co-glycolic acid) batches induced by the addition of silicone oil was studied, for peptide microencapsulation purposes.

Journal ArticleDOI
J. Herman1, J.P. Remon1
TL;DR: In this paper, the authors used thermally modified starches as excipients for sustained release tablets and found that the gel strength of hydrated tablets seemed proportional to the degree of amylose in the formulated starch.

Journal ArticleDOI
TL;DR: It is indicated, that the intercellular route of transport through the stratum corneum predominates, but that after longer transport times, apical corneocytes tend to take up some material, leading to a typical bimodal distribution of mercury.