Showing papers in "International Journal of Pharmaceutics in 1990"

TL;DR: Curcumin, a potent anti-inflammatory agent, has been studied for its ability to scavenge reactive oxygen radicals which are implicated in inflammation as discussed by the authors, and it has been shown that it is a good scavenger of hydroxyl radical at high concentrations but at low concentrations activated the Fenton system to generate an increased amount of hydrastic radical.

TL;DR: In this paper, the role of water in affecting drug entities that are believed to exist predominantly in the crystalline state, in the absence and presence of excipients and other drugs in the formulation.

TL;DR: In this paper, the authors evaluated the solubility of a series of fluoroquinolones as a function of pH, temperature, and salt concentration, and showed that increasing ionic strength may suppress the solusability more than could be explained by the common-ion effect alone.

TL;DR: In this article, a theoretical analysis of the collapse temperature of moxalactam di-sodium with 12% mannitol is presented, and a quantitative model based on these concepts is developed with key parameters being evaluated by experimental studies.

TL;DR: In this paper, the authors describe the current state of the art in the study of drug release from colloidal systems, focusing on the practical aspects of obtaining kinetic release data from micron or submicron-sized carriers.

TL;DR: In this paper, the effects of temperature and chamber pressure on secondary drying were analyzed using a vacuum microbalance and by Karl Fischer assay of vials sealed at selected times during secondary drying experiments conducted in a laboratory scale freeze dryer.

TL;DR: These methods are discussed in the light of difficulties associated with delivery of proteins, including their low permeability, rapid proteolysis, and denaturation within the delivery system.

TL;DR: In view of the overall results, it can be concluded that the release of diazepam from submicron emulsion is very rapid under perfect sink conditions.

TL;DR: In this article, the influence of both temperature and CYD concentration on complex solubility was studied using the method of Higuchi and Connors (Adv. Anal. Chem., 4 (1965) 117-212).

TL;DR: In this paper, the formation of interpolymer complexes of chitosan (CS) with sodium alginate (AL) and sodium polyacrylate (AC) was investigated, employing viscosity measurement, Fourier transform infrared (FT-IR) spectroscopy and elementary analysis.

TL;DR: The body distribution of surfactant-coated and noncoated poly(methyl methacrylate) nanoparticles with a size of 131 ± 30 nm was determined in rats.

TL;DR: The ability of a salt to lower the cloud point of HPMC gels was found to follow their order in the lyotropic series as discussed by the authors, i.e. chloride, and the ability of the salt to improve the performance of the gels.

TL;DR: In this article, the authors present the results obtained by changing the relaxation rate of the matrix by means of the application of impermeable coatings that partially cover the matrix, and the overall result is that the original kinetics of the uncoated matrix is shifted towards constant release.

TL;DR: These 30–50 nm nanoparticles were found to adsorb efficiently both hydrophilic (ampicillin) and hydrophobic (dexamethasone) drugs, and could open interesting perspectives for the delivery of drugs to sites other than the reticuloendothelial system.

TL;DR: In this article, the authors studied the swelling kinetics of polyvinyl alcohol (PVA) hydrogels in water and found that the rate of swelling linearly increased with the square root of immersion time in water.

TL;DR: In this paper, the authors present different examples of floating-force kinetics obtained from polymeric matrix floating forms, amongst which several are marketed products and others have undergone in vivo experiments conducted on human volunteers.

TL;DR: The subacute and subchronic intravenous toxicity of 2-hydroxypropyl-β-cyclodextrin was examined in Sprague-Dawley rats and cynomolgus monkeys and indicated that a single i.v. dose of HPCD as high as 10 g/kg was not lethal.

TL;DR: In this paper, the stability of liposomes to aerosolization was determined by analyzing the aerosol produced from liposomal formulations using a mulistage liquid impirger.

TL;DR: The results indicate that controlled drug delivery is a viable alternative in improving the therapeutic index of glaucoma therapy with timolol.

TL;DR: The polymorphism of furosemide has been extensively investigated and characterized using X-ray powder diffractometry, differential scanning calorimetry, infrared and Fourier transform infrared spectroscopy, elemental analysis, hot-stage microscopy and scanning electron microscopy as discussed by the authors.

TL;DR: The development of an oral dosage form rendering adequate bioavailability (10–20%) of insulin would simplify the lives of diabetics and make intensive treatment easier and further optimization of the insulin/mixed micelle solutions will be necessary to provide optimal absorption of intact insulin.

TL;DR: In this article, the Young's modulus at zero porosity (E0) provided a means of categorising the mechanical characteristics in terms of elasticity and rigidity (stiffness) and brittleness on a quantitative scale.

TL;DR: The authors discusses methods for quantitatively calculating the stability of fat emulsions in TPN mixtures, and their interpretation in the light of current knowledge of colloid stability is discussed.

TL;DR: In this article, a comparison between microspheres and starch powders (molecular weights: 25 000 and 11 000, respectively) shows that the insoluble starch of mol. wt. 11 000 does not affect the plasma glucose level.

TL;DR: The microsphere delivery system without added enhancer was capable of considerably enhancing the nasal absorption of hGH, and rapid and much higher absorption was observed when hGH was administered in combination with the microspheres and LPC as an enhancer.

TL;DR: The gastrointestinal transit of non-disintegrating tablets of different sizes (7–13 mm diameter) was investigated in fed subjects using the technique of gamma scintigraphy, with less variation between the individual data, than the smaller tablets.

TL;DR: An inclusion complex between famotidine and β-cyclodextrin was prepared by mixing the two components in a millimolar ratio in distilled water and heating under reflux for l h followed by stirring at room temperature for 5 days as mentioned in this paper.

TL;DR: In this article, it was shown that the cube root law will not be applicable to strictly monosized materials, for which a continuous decrease in particle size will occur, and the results in this study show that the decrease in mean particle size for fine particulate polydispersed powders is limited during dissolution.

TL;DR: In this article, the authors used the coefficient of variation (Xcv) of the fill weight of 20 capsules as an indicator of capsule filling performance and found a significant correlation between the values of Xcv and the flow parameters of Carr's compressibility, Hausner's ratio, angle of repose, Kawakita's equation constant (a), and Jenike's flow factor.

TL;DR: The results indicate that the new targeting system presented might be useful for local chemotherapy of esophageal cancer and also for other diseases of the alimentary canal.