Showing papers in "International Journal of Pharmaceutics in 2006"

TL;DR: This work has shown that addition of PEG and PEG-containing copolymers to the surface of nanoparticles results in an increase in the blood circulation half-life of the particles by several orders of magnitude, and creates a hydrophilic protective layer around the nanoparticles that is able to repel the absorption of opsonin proteins via steric repulsion forces.

TL;DR: The entire drug release kinetics of various published data and experimental data from commercial or prepared controlled release formulations of diltiazem and diclofenac are analyzed using the Weibull function to determine the mechanism of transport of a drug through the polymer matrix.

TL;DR: In this paper, a review of the most important developments in the field of drug dissolution from a historical point of view is presented, which is structured in a chronological order, from the theoretical foundations of dissolution, developed in the first half of the 20th century, and the development of a relationship between dissolution and bioavailability in the 1950s, going to the more recent development in the framework of the Biopharmaceutics Classification System (BCS).

TL;DR: The results demonstrate the feasibility of pharmaceutical cocrystal design based upon the crystallization preferences of a molecular analogue, and furthermore show that avoidance of hydrate formation and improvement in physical stability is possible via Pharmaceutical cocrystallization.

TL;DR: The results revealed that the encapsulation of verapamil in both calcium-alginate and calcium alginate-chitosan mixed beads exceeded 80% and the drug release mechanisms were either "anomalous transport" or "case-II transport".

TL;DR: Kinetic experiments demonstrated that the release process of DTX form nanospheres is affected by the molecular weight of the employed polymers, and suggested that DTX was molecularly dispersed in the polymeric matrices.

TL;DR: The formulation of ibuprofen as a nanosuspension, either in the form of lyophilized powder or granules, was very successful in enhancing dissolution rate, and the increase in in vitro dissolution rate may favourably affect bioavailability and improve safety for the patient by decreasing gastric irritancy.

TL;DR: The bioavailability of silybin in rats was increased remarkably after oral administration of s Lilybin-phospholipid complex comparing to sily bin-N-methylglucamine, mainly due to an impressive improvement of the lipophilic property of slybin- phospholIPid complex and improvement ofThe biological effect of sallybin.

TL;DR: The swelling properties were increased with increasing crosspovidone concentration and contributed significantly in drug release from the tablet matrix and the bioadhesive property of the developed formulation was found to be significant (P < 0.005) in combination as compared to HPMC K100M and psyllium husk alone.

TL;DR: Results suggested that both the penetration enhancing effect and the intact vesicle permeation into the stratum corneum might play a role in improving skin delivery of drugs by deformable liposomes, under non-occlusive conditions, and that the penetration enhances effect was of greater importance in case of ketotifen.

TL;DR: High initial microparticle porosities do not only lead to increased drug mobilities, but can also fundamentally alter the underlying mass transport mechanisms.

TL;DR: In this study it has been proved that using SLN as a drug carrier for oral administration of cyclosporine A a low variation in bioavailability of the drug and simultaneously avoiding the plasma peak typical of the first Sandimmun formulation can be achieved.

TL;DR: A new class of surfactants with glycerate headgroups, that form viscous lyotropic liquid crystalline phases in excess water, have been investigated for their potential to provide sustained release matrices for depot drug delivery, and their behaviour compared with that of glyceryl monooleate.

TL;DR: A novel hydrogel system composed of HTCC/glycerophosphate (HTCC/GP) with thermo- and pH-sensitivity was synthesized and used as an intelligent drug carrier and was transparent which made it suitable for some specific uses such as ocular drug formulation.

TL;DR: Results indicate that the studied microemulsion-based hydrogel may be a promising vehicle for topical delivery of ibuprofen.

TL;DR: Results showed that tretinoin cutaneous delivery is strongly affected by vesicle composition and thermodynamic activity of the drug, and small, negatively charged niosomal formulations, which are saturated with tretinin, have shown to give higher cutaneous drug retention than both liposomes and commercial formulation.

TL;DR: It is demonstrated that SLNs and WGA-modified SLNs promoted the oral absorption of insulin and protected insulin against degradation by digestive enzymes in vitro.

TL;DR: Alginate/HPMC mixture can be used as an in situ gelling vehicle to enhance ocular bioavailability and patient compliance and both in vitro release studies and in vivo pre-corneal retention studies indicated that the alginate or HPMC solution retained the drug better than theAlginates alone.

TL;DR: From the preliminary studies, cyclodextrin complexed insulin encapsulated mucoadhesive nanoparticles appear to be a good candidate for oral insulin delivery.

TL;DR: It was found out that nanoparticles overcoated by polysorbate 80 could significantly improve the drug level in both brain tissues and cerebrospinal fluids compared with uncoated ones and simple solution.

TL;DR: This paper discusses and summarizes current use and research of vaginal drug delivery systems based in gels and states that the simple formulation of a gel can lead to different performances of systems containing the same amount of active substances.

TL;DR: The results indicated that the NLC produced by solvent diffusion method could potentially be exploited as a carrier with improved drug loading capacity and controlled drug release.

TL;DR: This study showed the significance of each alginate property in modulating drug release: particle size is important in initial alginic acid gel barrier formation as it affected the extent of burst release; higherAlginate viscosity slowed down drug release rate in the buffer phase but enhanced release rate during the acid phase; high M-alginate might be more advantageous than high-G-alganate in sustaining drug release; and, the effect of increasing alginates concentration was greater

TL;DR: It is believed that the better wetting characteristics conferred by the hydrophilic surfactant was responsible for the enhanced dissolution rate and absolute oral bioavailability of the model drug.

TL;DR: In this work, polymer/inorganic hybrid core-shell microcapsules were fabricated for controlled release of poorly water-soluble drugs and polyelectrolyte multilayers assembled on the drug-loaded particles by the LbL reduced the release rate in both fluids.

TL;DR: In this article, the effect of lecithin:cholesterol molar ratio on the percentage drug encapsulated was investigated and the influence of fluctuating the amount of added drug was also determined.

TL;DR: This aim of this study was to encapsulate retinol into chitosan nanoparticles and reconstitute it into aqueous solution and zeta potential of reconstituted chito-encapsulated nanoparticles was similar to their original solution.

TL;DR: In this paper, magnetic poly epsilon-caprolactone (PCL) nanoparticles were prepared in a well shaped spherical form by the o/w emulsion method.

TL;DR: Artificial neural network as a multilayer perceptron feedforward network was incorporated for developing a predictive model of the formulations and no significant differences were found between the predictive abilities of IBP and BBP, although, the convergence speed of BBP is three- to four-fold higher than IBP.

TL;DR: The low cytotoxic biodegradable CSO-SA micelles could be used as an effective DNA condensation carrier for gene delivery system.