Showing papers in "International Journal of Pharmaceutics in 2009"

TL;DR: An overview of the cosmetic products currently on the market is given and the improvement of the benefit/risk ratio of the topical therapy is shown and the lipid nanoparticles are a "nanosafe" carrier.

TL;DR: The evidence for the existence of a direct nose-to-brain delivery route for nanoparticles administered to the nasal cavity and transported via the olfactory epithelium and/or via the trigeminal nerves directly to the CNS is evaluated.

TL;DR: These new nano-cargos have the ability to encapsulate efficiently lipophilic drugs, offering a pharmaceutical solution for their intravenous administration and should reduce considerably the cost and convenience for treatment.

TL;DR: Deep eutectic solvent can be a promising vehicle for increasing exposure of poorly soluble compounds in preclinical studies and in solubility in DES is 5 to 22,000 folds more than that in water.

TL;DR: This study pioneers the concept of the universality of low-energy nano-emulsification, proving that all these low- energy methods (i.e. spontaneous emulsification and the phase inversion temperature (PIT) method) are governed by a single unique mechanism.

TL;DR: The results of oral absorption experiment in mice showed that SMEDDS could significantly increase the oral absorption of curcumin compared with its suspension, illustrated that the developed SMED DS formulation held great potential as a possible alternative to traditional oral formulations ofCurcumin.

TL;DR: In vitro cytotoxicity was assessed using human lung adenocarcinoma cell lines SPC-A1 and A-549 and PTX-loaded P123/F127 mixed micelles may be considered as an effective anticancer drug delivery system for cancer chemotherapy.

TL;DR: Due to great thermosensitivity and biodegradability of these copolymers, PECE hydrogel is believed to be promising for in situ gel-forming controlled drug delivery system.

TL;DR: Several aspects of PCL-PEG copolymers are introduced, including synthetic chemistry, PCL -PEG micro/nanoparticles,PCL- PEG hydrogels, and physicochemical and toxicological properties.

TL;DR: The results showed that the type of surfactant, cholesterol and incorporated amount of drug altered the entrapment efficiency of niosomes, suggesting that these niosomal formulations could constitute a promising approach for the topical delivery of minoxidil in hair loss treatment.

TL;DR: Of all the stabilizers investigated, the HPMCs were the most effective both in terms of particle size reduction and short-term physical stability, and differences in stabilizer efficacy were observed between the two processing methods.

TL;DR: The results of this study forward ionically crosslinked CS/TPP nanoparticles as a biocompatible non-viral gene delivery system and generate a solid ground for further optimization studies, for example with regard to steric stabilization and targeting.

TL;DR: Pickering emulsions are new drug penetration vehicles with specific behavior; they are well-suited either for targeting the stratum corneum or aimed at slow release of drug from stratum Corneum used as a reservoir to the deeper layers of skin.

TL;DR: Slight increases in size were found for the Poloxamer and the Tween stabilized nanosuspensions, which is not considered to impair their use in dermal formulations.

TL;DR: It is proposed that the prepared system could be promising to improve oral efficacy of the tamoxifen citrate by realizing drug incorporation into an optimized nano-sized SNEDD system that encompasses a bioactive surfactant.

TL;DR: This work examines the advantageous effect of clay mineral as drug carrier for timolol maleate (TM), a nonselective beta-adrenergic blocking agent, and the intercalation of TM into the interlayer of montmorillonite (MMT).

TL;DR: The study indicated that the Tf-coupled PEG liposomes (Tf-SL) could be as the targeted carriers to facilitate the delivery of the encapsulated anticancer drugs into tumor cells by receptor-mediated way.

TL;DR: The skin absorption from Pickering emulsions as a new dosage form was investigated for the first time to focus on the effect of the interfacial layer on the drug release and skin absorption processes.

TL;DR: SEDDS have significantly increased the C(max) and area under the curve (AUC) of CoQ(10) compared to powder (P<0.05) and this self-micro emulsifying drug delivery system should be an effective oral dosage form for improving oral bioavailability of lipophilic drug, CoQ (10).

TL;DR: Endocytosis of PLGA NPs coated with transferrin on an in vitro model of the blood-brain barrier made of a co-culture of brain endothelial cells and astrocytes is evaluated and Tf-NPs were found to be highly adsorbed by the cells and endocytosed using an energy-dependent process.

TL;DR: In vivo measurements of pharmacokinetics and bioavailability demonstrated higher rates of fenofibrate absorption from both SPC/SDC and SPC/, indicating that liposomes containing bile salts may be used to enhance oral bioavailability of poorly water-soluble drugs.

TL;DR: Quantitative studies indicated that presence of PEI in PLGA nanoparticles resulted in 2-fold higher cellular uptake of nanoparticles while fluorescence microscopy studies showed that PLGA-PEI nanoparticles delivered the encapsulated siRNA in the cellular cytoplasm; both higher uptake and greater cytosolic delivery could have contributed to the gene silencing effectiveness of PLGA’s nanoparticles.

TL;DR: The LCH coating significantly modified the properties of liposome and brought a series of notable advantages for ocular drug delivery.

TL;DR: Physical appearance and the stability of the emulsion were greatly improved through an addition of glycerol, owing to its co-solvent and highly viscous property and the release rate related well to the protection time where a decrease in release rate can prolong mosquito protection time.

TL;DR: The improving dissolution behavior of the rutin nanocrystal-loaded tablet should lead to a better bioavailability of the poorly soluble rutIn in the body.

TL;DR: Compared to adsorption technique, desolvation/cross-linking technique improved the efficiency of drug loading regardless of type of gelatin used for the coating, and indicated involvement of electrostatic interaction during loading of DXR-to-coated IOPs.

TL;DR: Physical stability studies showed that the hydrocortisone nanosuspension remained homogeneous with slight increase in mean particle size and polydispersity index over a 3-month period.

TL;DR: The integrated multivariate approach exemplifies application of QbD principles and tools to drug product and process development and establishes design space to ensure desired CQAs.

TL;DR: It can be concluded from this study that SLNs provide a good skin targeting effect and may be a promising carrier for topical delivery of penciclovir.

TL;DR: Ex vivo experiments aimed at evaluating the capacity of heparin to prevent histamine release in rat mast cells indicated that the free or encapsulated drug exhibited the same dose-response behaviour.