Showing papers in "International Journal of Pharmaceutics in 2014"

TL;DR: Biocompatible with fibroblasts and keratinocytes, tissue engineered skin is indicated for regeneration and remodeling of human epidermis and wound healing improving the treatment of severe skin defects or partial-thickness burn injuries.

TL;DR: The study indicates that FF 3DP has the potential to offer a new solution for fabricating personalized-dose medicines or unit dosage forms with controlled-release profiles and the low cost of FDM printers means the paradigm of extemporaneous or point-of-use manufacture of personalized- dose tablets is both feasible and attainable.

TL;DR: Prior knowledge on Microcrystalline cellulose is gathered, its use in DC is focused on, some of its potential critical material attributes (CMAs) are listed and some of their potential criticalMaterial attributes ( CMAs) need to be thoroughly understood.

TL;DR: The printed formulations were evaluated for physical and mechanical properties such as weight variation, friability, hardness and thickness as a comparison to the commercial tablet and were within acceptable range as defined by the international standards stated in the United States Pharmacopoeia (USP).

TL;DR: This review highlights gene therapy as a new promising technique used to treat many incurable diseases and the different strategies used to transfer DNA, taking into account that introducing DNA into the cell nucleus without degradation is essential for the success of this therapeutic technique.

TL;DR: A commercial polymeric film (Parafilm M®, a blend of a hydrocarbon wax and a polyolefin) was evaluated as a model membrane for microneedle (MN) insertion studies as discussed by the authors.

TL;DR: Over the past few decades, microbial polysaccharides have been under intense investigation due to their advantageous physicochemical properties, which led to the development of controlled release forms based on gellan.

TL;DR: In vivo studies demonstrate that, wound healing takes place in less time as compared to drug unloaded patch and Hydroxyproline produced in wound bed with time demonstrates that wound healing rate is higher in case drug loaded PVA-NaAlg transdermal patch.

TL;DR: Diverse types of essential oil-fortified alginate films can find many applications mainly as disposable wound dressings but also in food packaging, medical device protection and disinfection, and indoor air quality improvement materials, to name a few.

TL;DR: The results showed that resveratrol-loaded solid lipid nanoparticles (SLN) serve as promising therapeutic systems to treat neoplastic diseases located in the brain tissue.

TL;DR: Octenidine loaded BNC presents a ready-to-use wound dressing for the treatment of infected wounds that can be stored over 6 months without losing its antibacterial activity.

TL;DR: The results support the use of nanoparticles made of PLGA and Eudragit S100 combination for CC delivery in IBD treatment, and significantly enhanced CC permeation across Caco-2 cell monolayers when compared to CC in suspension.

TL;DR: Based on these results, the pectin@chitosan/LDH-5ASA bionanocomposite beads could be proposed as promising candidates for the colon-targeted delivery of 5ASA, with the aim of acting only in the focus of the disease and minimizing side effects.

TL;DR: The main types of thermoresponsive polymers are reviewed, with special focus on decisive hydrogel characteristics, mechanisms of gelation, and biocompatibility, and promising biomedical applications are described.

TL;DR: Optimal apigenin-loaded ethosomes showed superior skin targeting both in vitro and in vivo and represent a promising therapeutic approach for the treatment of UVB-induced skin inflammation.

TL;DR: This study demonstrates the incorporation of anti-microbial nitrofurantoin in a polymer carrier material and subsequent 3D printing of a model structure, which resulted in an inhibition of biofilm colonization.

TL;DR: It is demonstrated that liposomal preparations to deliver curcumin increase its bioavailability and encapsulation by nanoliposome to achieve an improved bioavailability of a poorly absorbed hydrophobic compound.

TL;DR: It is concluded that the oral nanoemulsion of paclitaxel has got encouraging advantages over the presently available formulations of this injectable chemotherapeutic drug.

TL;DR: A novel pH-sensitive controlled release system is proposed by using mussel-inspired polydopamine (PDA) coated mesoporous silica nanoparticles (MSNs) as nanocarriers to control the release of drug molecules from MSNs in response to the pH-stimulus.

TL;DR: Results clearly indicated that STL-NP was a promising drug delivery system for peptide and protein drugs such as bFGF to enter the CNS and play the therapeutic role.

TL;DR: Every ZnO grade showed bactericidal and antifungal activity against the five tested micro-organisms in a concentration dependent manner and trends are related to their mechanisms of antimicrobial activity.

TL;DR: This study demonstrates microfluidics as a robust and high-throughput method for the scalable and highly reproducible manufacture of size-controlled liposomes and the application of statistically based process control increases understanding and allows for the generation of a design-space for controlled particle characteristics.

TL;DR: In vivo evaluation indicated that the sponge scaffold could offer effective support and attachment to cells for skin wound healing and was a potential skin tissue engineering material with appropriate physical properties and good biocompatibility.

TL;DR: BS-liposomes showed improved in vivo residence time and enhanced permeation across the biomemebranes and Mechanisms of trans-enterocytic internalization could be proposed as an interpretation for enhanced absorption of insulin-loaded liposomes.

TL;DR: It is demonstrated that electrospun PCM/CAF fibers comprise excellent candidates for oral fast-dissolving films, which could be particularly useful for children and patients with swallowing difficulties.

TL;DR: The in vitro drug release test results clearly suggested that Mt, and Mt along with AL were able to control the release of irinotecan by making it sustained, without any burst effect, and by reducing the released amount and the release rate.

TL;DR: The developed mechanical strength test method was suitable for all film types without the need of a pre-defined specimen and a mechanical strength threshold could be specified for future orodispersible film development.

TL;DR: A number of aspects related to OTDD are examined including the anatomy of the oral cavity, models currently used to study OTDD, as well as commercially available formulations and emerging technologies, which have advanced understanding of this route of drug delivery.

TL;DR: Results revealed that transfersomes could be promising for the non-invasive trans-tympanic delivery of ciprofloxacin and exhibited enhanced ex-vivo drug flux through ear skin and TM when compared with the commercial product (Ciprocin(®) drops).

TL;DR: The SMEDDS system could be likely a novel platform technology to improve the oral bioavailability of peptide drugs and evidence of a protective effect of oil-in-water (o/w) microemulsion droplets against enzymatic degradation of a peptide drug was provided.