Showing papers in "International Journal of Pharmaceutics in 2015"

TL;DR: This insures the protection of the fragile oil and controlled release of the essential oils for various applications such as in vitro diagnosis, therapy, cosmetic, textile, food etc.

TL;DR: This work has demonstrated the potential of 3DP to manufacture tablet shapes of different geometries, many of which would be challenging to manufacture by powder compaction.

TL;DR: This 'polypill' made by a 3D additive manufacture technique demonstrates that complex medication regimes can be combined in a single tablet and that it is viable to formulate and 'dial up' this single tablet for the particular needs of an individual.

TL;DR: In this review special attention has been paid to the application of double emulsion techniques for the encapsulation of various hydrophilic and hydrophobic anticancer drugs, anti-inflammatory drugs, antibiotic drugs, proteins and amino acids and their applications in theranostics.

TL;DR: This review mainly focuses on the influence of spin canting effects, introduced by the variations in size, shape, and organic/inorganic surface coatings, on the magnetic properties of SPIONs.

TL;DR: The potential of combining FDM 3D printing technology with established pharmaceutical processes, including HME and film coating, to fabricate modified release oral dosage forms has been demonstrated.

TL;DR: The therapeutic potential of resveratrol is outlined, its mechanisms of action and pharmacokinetic limitations are explored, and potential techniques to improve encapsulation of the drug within nanoparticles, thereby enhancing its clinical potential are highlighted.

TL;DR: It is demonstrated that research activities are highly diverse, targeting a broad range of pharmaceutical types and printing systems, and by categorising findings in terms of targeted business models and Active Pharmaceutical Ingredient (API) chemistry this can drive efficient translation of a chosen drug to inkjet manufacturing.

TL;DR: This review is an attempt to elucidate various synthesis strategies explored so far, including direct synthesis, " grafting in" and "grafting from" for the preparation of the P-AuNPs, to utilize the AuNPs as drug/nucleic acid delivery system for cancer therapy.

TL;DR: The technical and clinical aspects of ink-jet printing that must be considered in order for the technology to become widely adopted in the pharmaceutical arena are discussed and applications in the literature are considered.

TL;DR: The results showed that targeted MTX delivery might be achieved using topically applied niosomes for enhanced treatment of psoriasis.

TL;DR: This review summarizes the progress that has been made in recent years on nanofibers for biomedical use and highlights the major challenges that still remain to be solved.

TL;DR: The objectives, various methods and physicochemical and pharmacological outcomes have been reviewed with a scope including related fields of science and technology.

TL;DR: Production of amorphous solid dispersions with the HSES system proved to be flexibly scalable and easy to integrate into a continuous pharmaceutical manufacturing line, which opens new routes for the development of industrially relevant nanopharmaceuticals.

TL;DR: A particular focus is place on research performed on inhalable dry powder formulations of antitubercular drugs to target alveolar macrophages where the bacteria develop, as interesting alternatives to deliver directly drugs to the lungs and favor efficient TB treatment.

TL;DR: This review presents recent progress in glycerol monooleate liquid crystalline phases used as drug delivery vehicles.

TL;DR: The use of magnetic nanoparticles for cancer therapy and diagnosis is evaluated addressing potential applications in MRI, drug delivery, hyperthermia, theranostics and several other domains.

TL;DR: The nanocomplexes based on food-sourced biopolymers have promising features for oral delivery of nutrients and medicines and significantly improved the encapsulation capability of rutin studied as a model compound.

TL;DR: Results showed that SF/GT nanofibrous dressing is a promising topical drug delivery system that could be applied to promote healing and elicit anti-scar effects on partial-thickness burn wound.

TL;DR: The results from lymphatic transport and tissue distribution study indicate that a significant part of the EFV had by-passed portal system and was recovered in the lymph via chylomicron uptake mechanism, indicating that major amount of EFV bypasses the liver and thereby, enhances the oral bioavailability of theEFV.

TL;DR: An overview to the basics of rheology is given and examples of different experimental set-ups available for rheological measurements are presented, discussing each of their typical application area, advantages and limitations.

TL;DR: A therapeutic DES based on ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), and menthol was synthesized and its thermal behavior was analyzed by differential scanning calorimetry (DSC), providing important clues for the development of carriers for the sustainable delivery of bioactive compounds.

TL;DR: Both, ex vivo permeation and in vivo skin deposition studies confirmed the superiority of bilosomes over drug solution in delivering TX transdermally and in vitro histopathological study proved the safety of topically applied bilosome.

TL;DR: Inkjet printing has been shown to be an effective technology for coating of metal microneedles which can then be used for further transdermal drug delivery applications.

TL;DR: In vivo studies proved that magnetic targeted drug delivery can provide a higher accumulation of drug throughout tumor compared with that delivered by passive targeting, and MTD technology not only minimizes the random distribution of the chemotherapeutic agents, but also reduces their side effects to healthy tissues, which are the two primary concerns in conventional cancer therapies.

TL;DR: The constructed Fe3O4@TiO2 NPs are endowed with multifunctions which allow them to selectively deliver combinatorial therapeutic payload to tumor with enhanced therapeutic effectiveness and minimal side effects.

TL;DR: The aim of this review is to focus on the conversion of amorphous solid dispersions into tablets highlighting results from various viewpoints.

TL;DR: A review of drug delivery systems or devices evaluated in research and clinic over the last decade for inner ear applications highlights the promising systems for future clinical applications as well as the current hurdles that remain to be overcome for efficient inner ear therapy.

TL;DR: EpCAM-targeted PEG-PLGA nanopolymersomes will lead to an improved therapeutic index of doxorubicin to EpCAM positive cancer cells, and were significantly more cytotoxic toward EpCam-positive tumor cells (MCF-7) than non- targeted nanopolymeromes.

TL;DR: Resveratrol and 5-fluorouracil co-loaded ultradeformable liposomes could be a new nanomedicine for the treatment of squamous cell carcinoma, i.e., actinic keratosis, Bowen's disease, and keratoacanthoma.