International Journal of Radiation Biology 

About: International Journal of Radiation Biology is an academic journal published by Informa. The journal publishes majorly in the area(s): Radiosensitivity & DNA damage. It has an ISSN identifier of 0955-3002. Over the lifetime, 8730 publications have been published receiving 224300 citations. The journal is also known as: Radiation biology.

WHO Handbook for Reporting Results of Cancer Treatment

Abstract: (1980). WHO Handbook for Reporting Results of Cancer Treatment. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine: Vol. 38, No. 4, pp. 481-481.

Free Radicals in Biology: Oxidative Stress and the Effects of Ionizing Radiation

Abstract: The most important electron acceptor in the biosphere is molecular oxygen which, by virtue of its bi-radical nature, readily accepts unpaired electrons to give rise to a series of partially reduced species collectively known as reduced (or ‘reactive’) oxygen species (ROS). These include superoxide (O·-2), hydrogen peroxide (H2O2), hydroxyl radical (HO·) and peroxyl (ROO·) and alkoxyl (RO·) radicals which may be involved in the initiation and propagation of free radical chain reactions and which are potentially highly damaging to cells. Mechanisms have evolved to restrict and control such processes, partly by compartmentation, and partly by antioxidant defences such as chain-breaking antioxidant compounds capable forming stable free radicals (e.g. ascorbate, α-tocopherol) and the evolution of enzyme systems (e.g. superoxide dismutase, catalase, peroxidases) that diminish the intracellular concentration of the ROS. Although some ROS perform useful functions, the production of ROS exceeding the ability of th...

Initial events in the cellular effects of ionizing radiations: clustered damage in DNA.

Abstract: General correlations are found between the detailed spatial and temporal nature of the initial physical features of radiation insult and the likelihood of final biological consequences. These persist despite the chain of physical, chemical and biological processes that eliminate the vast majority of the early damage. Details of the initial conditions should provide guidance to critical features of the most relevant early biological damage and subsequent repair. Ionizing radiations produce many hundreds of different simple chemical products in DNA and also multitudes of possible clustered combinations. The simple products, including single-strand breaks, tend to correlate poorly with biological effectiveness. Even for initial double-strand breaks, as a broad class, there is apparently little or no increase in yield with increasing ionization density, in contrast with the large rise in relative biological effectiveness for cellular effects. Track structure analysis has revealed that clustered DNA damage of ...

Ionizing Radiation: Sources and Biological Effects

Abstract: (1983). Ionizing Radiation: Sources and Biological Effects. International Journal of Radiation Biology and Related Studies in Physics, Chemistry and Medicine: Vol. 43, No. 5, pp. 585-586.

Microcolony survival assay for cells of mouse intestinal mucosa exposed to radiation.

Abstract: SummaryA microcolony technique for assaying the survival of small proportions of the clonogenic cells of the mucosa of the small intestine of mice is described. The radiosensitivity of intestinal crypt cells measured by the technique is the same as that measured by a macrocolony method. However, the microcolony technique has the special advantage of being useful for assaying cell survival after whole-body radiation.