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Showing papers in "iScience in 2021"


Journal ArticleDOI
06 Feb 2021-iScience
TL;DR: In this article, gene expression profiles of three SARS-CoV and SARS CoV-2 infected human cell lines were reported, and it was shown that SARS co-virus infection elicited an approximately two-fold higher stimulation of the innate immune response compared to SARS in the human epithelial cell line Calu-3, including induction of miRNA-155.

164 citations


Journal ArticleDOI
19 Mar 2021-iScience
TL;DR: In this paper, the authors introduce state-of-the-art manufacturing technology and analyze the cost, throughput, and energy consumption based on the production processes of Li-ion batteries.

136 citations


Journal ArticleDOI
17 Apr 2021-iScience
TL;DR: This review critically revise recent approaches for the improvement of in vitro and in vivo biofilm models and presents an updated overview of biofilm formation.

97 citations


Journal ArticleDOI
23 Apr 2021-iScience
TL;DR: In this article, a panel of already approved drugs in a cell culture model of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and identified two new agents having higher antiviral potentials than the drug candidates such as remdesivir and chroloquine in VeroE6/TMPRSS2 cells: the anti-inflammatory drug cepharanthine and human immunodeficiency virus protease inhibitor nelfinavir.

96 citations


Journal ArticleDOI
22 Jan 2021-iScience
TL;DR: This paper focuses on analyses at different phenotype levels, from biochemical to yield, and in connecting genotypes to these, illustrating how machine learning offers a suite of methods that enable researchers to find meaningful patterns in relevant plant data.

92 citations


Journal ArticleDOI
19 Mar 2021-iScience
TL;DR: In this paper, the authors reveal that the Immunoglobulin-like fold ectodomain of the viral protein SARS-CoV-2 ORF7a interacts with high efficiency to CD14+ monocytes in human peripheral blood.

91 citations


Journal ArticleDOI
Xianjie Pu1, Shanshan An1, Qian Tang1, Hengyu Guo1, Chenguo Hu1 
05 Jan 2021-iScience
TL;DR: In this paper, a comprehensive overview of some key progresses in this field over last 5 years are presented, and the major types of HMIs taking these biomedical monitoring as basis are introduced accordingly: eye movement, voice/auditory, gesture/joint movement, and touch/tactile based HMIs.

88 citations


Journal ArticleDOI
22 Jan 2021-iScience
TL;DR: The development of 3D-printed microneedles has enabled the evolution of pain-free controlled release drug delivery systems, devices for extracting fluids from the cutaneous tissue, biosignal acquisition, and point-of-care diagnostic devices in personalized medicine as discussed by the authors.

85 citations


Journal ArticleDOI
19 Feb 2021-iScience
TL;DR: In this paper, the authors survey approaches that enable the use of longer wavelengths and show that the wavelength and intensity of photons are import parameters that enable tuning of the reactivity of a photocatalyst to control or change the selectivity of chemical reactions.

79 citations


Journal ArticleDOI
09 Mar 2021-iScience
TL;DR: Zhang et al. as discussed by the authors demonstrated that SARS-CoV-2 coding protein open reading frame 8 (ORF8) acted as a contributing factor to cytokine storm during COVID-19 infection.

79 citations


Journal ArticleDOI
12 Feb 2021-iScience
TL;DR: In this article, the authors review the research progress of energy-related applications of high-entropy materials (HEMs) and discuss the challenges and future directions for developing HEMs.


Journal ArticleDOI
09 Mar 2021-iScience
TL;DR: This paper showed that GU-rich single-stranded RNA (GU-rich RNA) derived from SARS CoV-2, SARS-CoV-1, and HIV-1 trigger a TLR8-dependent pro-inflammatory cytokine response from human macrophages in the absence of pyroptosis.

Journal ArticleDOI
22 Jan 2021-iScience
TL;DR: This review introduces the evolution of wearable EHs from a single effect to hybridized mechanisms for multiple energy sources and wearable to implantable self-sustainable systems and perspectives on the future development of hybrid EHS to be more competitive with conventional batteries.

Journal ArticleDOI
22 Jan 2021-iScience
TL;DR: This paper reviews recent progresses in this emerging area, especially new concepts, approaches, and applications of machine learning technologies for commonly used energy storage devices and systems and the perspective on future directions is discussed.

Journal ArticleDOI
23 Jul 2021-iScience
TL;DR: In this paper, the authors present a comprehensive, holistic techno-economic model as a framework to directly compare recycling locations and processes, providing a key tool for recycling cost optimization in an international battery recycling economy.


Journal ArticleDOI
22 Jan 2021-iScience
TL;DR: In this article, a review of biofilm formation on titanium dental implants and key factors to be considered in therapeutic and preventative strategies was presented. And a systematic review was conducted on coatings developed for titanium surfaces using different antibiotics, which shed light on potential alternative strategies aiming to reduce microbial loads and control polymicrobial infection.

Journal ArticleDOI
23 Apr 2021-iScience
TL;DR: In this article, the safety and immunogenicity of a whole virion inactivated (WVI) SARS-CoV-2 vaccine (BBV152), adjuvanted with aluminum hydroxide gel (Algel), or TLR7/8 agonist chemisorbed Algel, were evaluated in mice, rats, and rabbits.


Journal ArticleDOI
19 Feb 2021-iScience
TL;DR: In this article, the authors present a large-scale analysis of intra-host genomic diversity, which reveals that most samples exhibit heterogeneous genomic architectures, due to the interplay between host-related mutational processes and transmission dynamics.

Journal ArticleDOI
22 Jan 2021-iScience
TL;DR: Using a rational ligand-based interface design complemented with mutational mapping, the authors generated a total of 100,000 mutations and provided insight into the functional outcomes of mutations in the remdesivir-binding site in nsp12 subunit of RdRp.

Journal ArticleDOI
09 Aug 2021-iScience
TL;DR: In this paper, the authors analytically investigated hydrogenation systems' technical and economic prospects using liquid organic hydrogen carriers (LOHCs) to store hydrogen at a large scale compared to densified storage technologies and circular hydrogen carriers.

Journal ArticleDOI
26 Sep 2021-iScience
TL;DR: In this paper, the authors summarize current development of skin-inspired hydrogel devices to address the challenges of limited functionality, low ambient stability, poor surface adhesion, and relatively high power consumption as ionic sensors.

Journal ArticleDOI
19 Mar 2021-iScience
TL;DR: In this article, the authors discuss the latest advances in the application of NIR QDs in preclinical settings, together with the synthetic approaches and material developments that make NIRQDs promising for future biomedical applications.

Journal ArticleDOI
23 Apr 2021-iScience
TL;DR: In this article, an electrostatic-modulated interfacial polymerization (eIP) via supercharged phosphate-rich substrates toward ultra-permselective polyamide membranes is presented.

Journal ArticleDOI
25 Jun 2021-iScience
TL;DR: In this article, a possible route to the carbon neutral target based on energy-chemical nexus for electricity generation as well as methanol and ammonia production is proposed in China, where the most cost-effective solution for meeting the commitment is identified by considering regional variations in renewable and non-renewable resources and adopting an optimized regional cooperation.

Journal ArticleDOI
06 Feb 2021-iScience
TL;DR: For materials science, text mining (TM) methodology is still at the dawn of its development as mentioned in this paper, and a broad class of researchers aiming to learn the fundamentals of TM as applied to the materials science publications.

Journal ArticleDOI
22 Jan 2021-iScience
TL;DR: The crystal structure of the globular domain of SARS-CoV-2 Nsp1 is reported, encompassing residues 13 to 127, at a resolution of 1.65 Å, and reveals how variations in amino acid sequence manifest as distinct structural features.

Journal ArticleDOI
21 May 2021-iScience
TL;DR: In this article, the transcriptional landscape of the various cell populations that compose human teeth at single-cell resolution was mapped and analyzed in deeper detail, showing that the molecular signatures of the stem cell populations were similar, while their respective microenvironments strongly diverged.