JACC: Basic to Translational Science 

TL;DR: The potential mechanisms by which SGLT2 inhibitors exert their beneficial effects are discussed, including beneficial effects on cardiac energy metabolism, reducing inflammation, improving kidney function, and increasing erythropoiesis.

TL;DR: In this article, the authors evaluated cardiac energy production and bioenergetics in an experimental model of diabetes treated with the SGLT2 inhibitor empagliflozin.

TL;DR: The virology and potential mechanism of injury form the basis for a discussion of potential disease-modifying therapies, and several mechanisms of injury are proposed with a focus on cardiovascular complications.

TL;DR: A review of animal testing in pharmaceutical and industrial research to predict human toxicity is presented in this article, where the authors argue that animal models are poor predictors of drug safety in humans and propose alternatives to animal research and their validation and use in production of human pharmaceuticals.

TL;DR: This 2-part series is intended to provide an overview of the steps involved in bringing new drugs and devices through the FDA process, including the process of new drug approvals, and continues with approval of medical devices.