scispace - formally typeset
Search or ask a question

Showing papers in "Japanese Journal of Allergology in 1995"


Journal Article
TL;DR: Fresh biopsies showed that asthma patients can have epithelial destruction at all levels of the airways, and Epithelial destruction in the respiratory tract of the asthma patients with mild to severe bronchial hyperresponsiveness was prominent enough to expose the epithelial nerves for specific or nonspecific stimuli.

1,151 citations


Journal ArticleDOI
TL;DR: Rxithromycin dose dependently inhibited the pathological changes in lung tissues induced by H. influenzae infection and enhanced 2',5'-oligoadenilate synthetase production in response to infection.
Abstract: The effects of roxithromycin (RXM), an antibiotic of the macrolide family, on respiratory bacterial infection in mice were examined. BALB/c mice were administered with RXM orally at a dose of 5.0 or 2.5 mg/kg once per day for 14 days. On day 2 after the final drug administration, the mice were nasally infected with Haemophilus influenzae. RXM dose dependently inhibited the pathological changes in lung tissues induced by H. influenzae infection. RXM also enhanced 2',5'-oligoadenilate synthetase production in response to infection.