Showing papers in "Journal of Biological Chemistry in 1996"

TL;DR: The tissue-specific expression of a putative secreted protein suggests that this factor may function as a novel signaling molecule for adipose tissue.

TL;DR: It is demonstrated that FGF 1 is the only FGF that can activate all FGF receptor splice variants and the relative activity of all the other members of the FGF family is determined.

TL;DR: The phosphorylation of MLC by Rho-kinase resulted in the facilitation of the actin activation of myosin ATPase, which may partly account for the mechanism by which Rho regulates cytokinesis, cell motility, or smooth muscle contraction.

TL;DR: This review compares and contrast PGHS-1 and -2 in the context of the regulation of expression of the two enzymes, the mechanisms of enzyme catalysis, and the biological significance of having two PGHSs.

TL;DR: This compound offers a useful new tool for examining the role of the Lck and FynT tyrosine kinases versus ZAP-70 in T cell activation as well as the roles of other Src family kinases in receptor function.

TL;DR: Results suggest that, along with other family members such as Fas/Apo-1 ligand and TNF, Apo-2L may serve as an extracellular signal that triggers programmed cell death.

TL;DR: It is demonstrated that functional hypoxia response elements in the promoters of the ALDA, ENO1, and Ldha genes consist of a pair of contiguous transcription factor binding sites at least one of which contains the core sequence 5′-RCGTG-3′ and is recognized by HIF-1.

TL;DR: It is shown that Akt can regulate glucose uptake and metabolism and is expressed in 3T3-L1 adipocytes directed lipid but not glycogen synthesis.

TL;DR: The notion that MAPK cascades drive specific cell cycle responses to extracellular stimuli, at least in part, through the modulation of cyclin D1 expression and associated cdk activities is supported.

TL;DR: This finding is consistent with the recent report that the AMP-activated protein kinase kinase can slowly phosphorylate and activate calmodulin-dependentprotein kinase I, at least in vitro.

TL;DR: Insight is provided into mechanisms of MAPK regulation by H2O2 and ERK plays a critical role in cell survival following oxidant injury and is suggested to have a role for growth factor receptors in this activation.

TL;DR: Results suggest that an intact redox-dependent signaling pathway is required for destablization of the HIF-1α protein, which was rapidly and drastically decreased in vivo following an abrupt increase to normal oxygen tension.

TL;DR: [3H]Gabapentin is the first pharmacological agent described that interacts with an α subunit of a voltage-dependent Ca channel, and binding activity closely followed the elution of the α sub unit.

TL;DR: The present demonstration, that a reverse helix and a helix composed of D-enantiomers still translocate across biological membranes at 4 and 37°C strongly suggests that the third helix of the homeodomain is internalized by a receptor-independent mechanism.

TL;DR: Although architecturally homologous to the Ras/MAPK pathway, the SAPK and p38 pathways are not activated primarily by mitogens but by cellular stresses and inflammatory cytokines, which stimuli result in growth arrest, apoptosis, or activation of immune and reticuloendothelial cells.

TL;DR: Structural features of the HIF-1α subunit that are required for heterodimerization, DNA binding, and transactivation of hypoxia-inducible factor 1 are reported.

TL;DR: It is demonstrated using Northern analysis that treatment of various cell lines with IL-6 for 6-48 h results in a significant induction of VEGF mRNA, and it is shown that the 5′-UTR is important for the expression of V EGF.

TL;DR: It is shown that caveolin interacts with another well characterized signal transducer, Ras, and that recombinant overexpression of caveolin in intact cells is sufficient to functionally recruit a nonfarnesylated mutant of Ras onto membranes, overcoming the normal requirement for lipid modification of Ras.

TL;DR: It is shown that peptides incorporating a short Aβ fragment (KLVFF; Aβ) can bind full-length Aβ and prevent its assembly into amyloid fibrils and suggested that residues Aβ serve as a binding sequence during Aβ polymerization and fibril formation.

TL;DR: The data revealed the requirement of the JNK pathway in radiation-induced apoptosis and implicated the importance of the duration of JNK activation in determining the cell fates.

TL;DR: Analysis of the substrate specificity of collagenase-3 revealed that soluble type II collagen was preferentially hydrolyzed, while the enzyme was 5 or 6 times less efficient at cleaving type I or III collagen.

TL;DR: Findings strongly suggest Flt-1 as a functional receptor for VEGF and PlGF in monocytes and endothelial cells and identify this receptor as a mediator of monocyte recruitment and procoagulant activity.

TL;DR: The effort to decipher the mechanism of Alzheimer's disease has attracted the interest of investigators from diverse biological disciplines, including biochemistry, cell biology, molecular genetics, neuroscience, and structural biology, and it is increasingly likely that AD will become a premier example of the successful application of biological chemistry to the identification of rational therapeutic targets in a major human disease.

TL;DR: This work reports that an N-terminal truncation of one of these candidate signal transducers, FADD/MORT1, abrogates CD95-induced apoptosis, ceramide generation, and activation of the cell death protease Yama/CPP32.

TL;DR: The results suggest that lipid peroxidation, as well as glycoxidation, may be an important source of CML in tissue proteins in vivo and that CML may be a general marker of oxidative stress and long term damage to protein in aging, atherosclerosis, and diabetes.

TL;DR: It is demonstrated that β2-adrenergic receptors do form SDS-resistant homodimers and that transmembrane domain VI of the receptor may represent part of an interface for receptor dimerization, which suggests that interconversion between monomeric and dimeric forms may be important for biological activity.

TL;DR: The first evidence that p22phox is a critical component of superoxide-generating vascular NADH/NADPH oxidase is provided, suggesting a central role for this oxidase system in vascular hypertrophy is suggested.

TL;DR: It appears that caveolin structurally and functionally interacts with wild-type c-Src via caveolin residues 82-101, and this cytosolic caveolin domain has the following unique features: it is membrane-proximal, suggesting that it may be involved in other potential protein-protein interactions.

TL;DR: In this paper, a new MAP kinase, p38β, was characterized, which is a 372-amino acid protein most closely related to p38 and showed a strong substrate preference for activating transcription factor 2 (ATF2).

TL;DR: Localization to this microdomain is likely to optimize eNOS activation and the extracellular release of nitric oxide and that both myristoylation and palmitoylation are required to target the enzyme to caveolae and that each acylation process enhances targeting by 10-fold.