Journal of Brain Research-journal Fur Hirnforschung 

About: Journal of Brain Research-journal Fur Hirnforschung is an academic journal. The journal publishes majorly in the area(s): Prefrontal cortex & Neural crest. Over the lifetime, 12 publications have been published receiving 24 citations.

Antibody-dependent Fos-like immunoreactivity (FLI) in the auditory pathway of the rat in response to electric stimulation of the cochlea.

Abstract: The distribution of Fos-like immunoreactivity (FLI) in the auditory pathway was analyzed and quantified in two groups of rats subjected to a similar electric stimulation of the cochlea, but the brains of the two groups were treated with a different antibody against Fos. The brains of control (unstimulated) rats were processed and analyzed in the same way. In a given auditory nucleus, for the same paradigm of stimulation, a very different density of FLI can be found depending on the antibody used to process the tissue. There are auditory nuclei which exhibited a significant activation of FLI as compared to control animals when one antibody was used whereas there was no difference when using the other antibody. In other cases, for both antibodies, a significant FLI increase was observed in relation to the stimulus. However, the increase of FLI density was significantly greater in some auditory nuclei with one antibody, while it was the reverse in other auditory nuclei. The present data demonstrate quantitatively that the use of two different Fos antibodies can strongly affect the FLI produced in the auditory pathway by electric stimulation of the cochlea, confirming previous qualitative observations based on acoustic stimulation of the cochlea.

Selective stimulation of orexin receptor type 2 promotes wakefulness in freely behaving rats

Abstract: Orexins A and B are a pair of neuropeptides implicated in the regulation of feeding and arousal behavior mediated through two orexin receptors type 1 and type 2. We have determined the arousal effects of newly developed selective orexin receptor type 2 agonist, [Ala 11 ]orexin-B, on the sleep–wake cycle in rats. The effects of third ventricle intracerebroventricular (ICV) infusion of the novel orexin receptor type 2 selective agonist, [Ala 11 ]orexin-B, on the sleep–wake cycle were investigated. ICV infusion of [Ala 11 ]orexin-B (1, 10 and 40 nmol) during the light period (11:00–16:00) dose-dependently resulted in a significant increase in wake duration by 46.9% ( n = 5, P n = 4, P n = 7, P P P n = 6, non-significant), 99.8% ( n = 6, P n = 4, P n = 6, P n = 6, P n = 6, P

Brain Injury and SARS-CoV-2 Infection: Bidirectional Pathways

Abstract: Coronavirus Infection Disease (COVID-19) is a recent pandemic infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV2), ongoing in Wuhan, China that earlier known as Wuhan pneumonia. COVID-19 was declared by the World Health Organization (WHO) as a pandemic disease on March 11th, 2020. As of October, 2020, there have been total of 34,392,166 confirmed cases with 1,022,391 deaths globally.

Synaptic reorganisation of the mediodorsal thalamic nucleus in adult rat following chronic prefrontal cortical lesions.

Abstract: Chronic changes in the thalamic mediodorsal nucleus (MD) after unilateral lesions of the prefrontal cortex were studied with the aid of quantitative light, and electron microscopic immunohistochemistry. Three months after the lesions, although the size of MD ipsilateral to the lesion did not change considerably, the neuronal density was significantly reduced. Conversely, as demonstrated by quantitative electron microscopy, the density of GABA immunostained axon terminals significantly increased in the lesioned side. It is suggested, that as MD does not contain GABA cells, the reactive hyperinnervation of the MD by GABA-containing axons is of extrinsic origin. This finding is also the morphological evidence of the potential of GABA-ergic nerve cells for reactive (induced) axonal sprouting.