Journal of Burn Care & Research 

About: Journal of Burn Care & Research is an academic journal published by Oxford University Press. The journal publishes majorly in the area(s): Medicine & Burn injury. It has an ISSN identifier of 1559-047X. Over the lifetime, 3725 publications have been published receiving 51570 citations. The journal is also known as: Journal of burn care and research & Burn care & research.

Cutaneous Wound Healing

Abstract: Overall, burns are smaller than 20 years ago, but even small burns can leave patients with debilitating scars. The management of the burn wound and resultant scarring requires the integration of multiple disciplines. Despite our best efforts, the evaluation and treatment of burn wounds and burn scars has not been completely elucidated. The purpose of this work is to describe the state of knowledge regarding wound healing, both what is known and what is not known, and to recap the priorities set by the breakout sessions of the Burn State of the Science: Research meeting. Wound challenges in 2007 include wound coverage for patients with extensive full-thickness burns, management of donor sites and partial-thickness burns, and reduction of longterm morbidity from burn scars.

American Burn Association consensus conference to define sepsis and infection in burns

Abstract: Because of their extensive wounds, burn patients are chronically exposed to inflammatory mediators. Thus, burn patients, by definition, already have "systemic inflammatory response syndrome." Current definitions for sepsis and infection have many criteria (fever, tachycardia, tachypnea, leukocytosis) that are routinely found in patients with extensive burns, making these current definitions less applicable to the burn population. Experts in burn care and research, all members of the American Burn Association, were asked to review the literature and prepare a potential definition on one topic related to sepsis or infection in burn patients. On January 20, 2007, the participants met in Tucson, Arizona to develop consensus for these definitions. After review of the definitions, a summary of the proceedings was prepared. The goal of the consensus conference was to develop and publish standardized definitions for sepsis and infection-related diagnoses in the burn population. Standardized definitions will improve the capability of performing more meaningful multicenter trials among burn centers.

Molecular mediators of angiogenesis.

Abstract: Angiogenesis, or the formation of new blood vessels from the preexisting vasculature, is a key component in numerous physiologic and pathologic responses and has broad impact in many medical and surgical specialties. In this review, we discuss the key cellular steps that lead to the neovascularization of tissues and highlight the main molecular mechanisms and mediators in this process. We include discussions on proteolytic enzymes, cell-matrix interactions, and pertinent cell signaling pathways and end with a survey of the mechanisms that lead to the stabilization and maturation of neovasculatures.

American Burn Association practice guidelines burn shock resuscitation.

Abstract: : There are insufficient data to support a treatment standard treatment at this time. Guidelines - Adults and children with burns greater than 20% TBSA should undergo formal fluid resuscitation using estimates based on body size and surface area burned. - Common formulas used to initiate of resuscitation estimate a crystalloid need for 2 to 4 ml/kg body weight/%TBSA during the first 24 hours. - Fluid resuscitation,regardless of solution type or estimated need, should be titrated to maintain a urine output of approximately 0.5 1.0 ml/ kg/hr in adults and 1.0 1.5 ml/kg/hr in children. - Maintenance fluids should be administered to children in addition to their calculated fluid requirements caused by injury. - Increased volume requirements can be anticipated in patients with full-thickness injuries, inhalation injury, and a delay in resuscitation. Options - The addition of colloid-containing fluid following burn injury, especially after the first 12 to 24 hours postburn, may decrease overall fluid requirements.

The phenomenon of fluid creep in acute burn resuscitation

Abstract: Several reports have documented that modern burn patients receive far more resuscitation fluid than predicted by the Parkland formula-a phenomenon termed "fluid creep" This article reviews the incidence, consequences, and possible etiologies of fluid creep in modern practice and uses this information to propose some therapeutic strategies to reduce or eliminate excessive fluid resuscitation in burn care A literature review was performed of historical references that form the foundation of modern fluid resuscitation, as well as reports of fluid creep and its consequences The original Parkland formula required a 24-hour volume of 4 ml/kg/%TBSA lactated Ringer's solution followed by an infusion of 03-05 ml/kg/ %TBSA plasma Modern iterations of this formula have omitted the colloid bolus Numerous exceptions to the formula have been noted, most consistently patients with inhalation injuries In contrast, recent reports document greatly increased fluid requirements in unselected patients, which seems to consist largely of progressive edema formation in unburned areas, increasing after the first 8 hours post-burn This has been linked to occurrence of the abdominal compartment syndrome and other serious complications Strategies to reduce fluid creep include the avoidance of early overresuscitation, use of colloid as a routine component of resuscitation or for "rescue," and adherence to protocols for fluid resuscitation Fluid creep is a significant problem in modern burn care Review of original investigations of burn shock, coupled with modern reports of fluid creep, suggests several mechanisms by which this problem can be controlled Prospective trials of these therapies are needed to confirm their effectiveness