Showing papers in "Journal of Cellular and Comparative Physiology in 1957"

Immunology of bone marrow transplantation.

Abstract: The role of the recognition factor of an antibody-producing cell and its relative sensitivity to x rays has a great implication, not only to radiation immunology but to general biology. Obviously, much work is still required to elucidate this problem. From an immunologist's point of view, one of the most fascinating phenomena of the bone marrow transplantation studies is the delayed foreign bone marrow reaction. The task of circumventing or subduing the reaction is a formable one, considering the large number of immunochemically distinct antigens existing in a given bone marrow suspension. Preliminary studies seem to indicate that the nuclear membrane or the nuclear material, or both, are mainly responsible for the delayed foreign bone marrow reaction. Should the nuclear material be found to be the chief agent involved in this delayed reaction, the problem then becomes ever more challenging since the antigenic material is chemically impure and its solubility in aqueous medium is limited.