Journal of Chinese Oncology 

About: Journal of Chinese Oncology is an academic journal. The journal publishes majorly in the area(s): Cancer & Breast cancer. Over the lifetime, 49 publications have been published receiving 86 citations.

The Effect of Chonglou Saponin I on Proliferation and Apoptosis in Lung Adenocarcinoma Cell Line PC9

Abstract: [Purpose] To investigate the effect of Chonglou Saponin I on proliferation and apoptosis in lung adenocarcinoma cell line PC9.[Methods] The effect of Chonglou Saponin I on cell prolifera-tion,cell cycle and cell apoptosis were detected by MTT method,FCM and Annexin-V-FITC/PI respectively.The expressions of Bcl-2,Bax and caspase-3 were detected by Western blot.[Results] The growth of PC9 cells was inhibited by Chonglou Saponin I in a dose-and time-dependent manner.After treated with 2.5μg/ml Chonglou Saponin I 12h,24h and 48h,cell cycle was arrested in the G2/M phase.Compared with control group,cell apoptosis was induced significantly(P0.01) after treated with 2.5μg/ml Chonglou Saponin I at 24h and 48h.The expression of Bcl-2 protein decreased,and the expressions of Bax and caspase-3 protein increased after treated with 2.5μg/ml Chonglou Saponin I at 48h.[Conclusion] Chonglou Saponin I can inhibit cell prolife-ration of lung adenocarcinoma cell line PC9 in a dose-and time-dependent manner.The mechanism might relate to G2/M arrested,inducing cell apoptosis,decreasing expression of Bcl-2,increasing expression of Bax and caspase-3.

A Prospective and Randomized Study of Induction Chemotherapy Combined with Concurrent Chemoradiotherapy in the Treatment for Nasopharyngeal Carcinoma Stage T_(3～4)N_(2～3)M_0

Abstract: [Purpose] To investigate the clinical response of induction chemotherapy combined with concurrent chemoradiotherapy.[Methods] From May 2008 to June 2009,a total of 112 patients with nasopharyngeal carcinoma(NPC) stage T3～4N2～3M0 were randomized into test group(57 patients) and control group(55 patients).Two groups received the same radiotherapy.Test group received induction chemotherapy combined with concurrent chemoradiotherapy and control group received concurrent chemoradiotherapy alone.The induction chemotherapy regimen including DDP(30mg/m2,d1～3),continuous 5-Fu infusion(450mg/m2,d1～3) every 3 weeks for 2 cycles.Concurrent chemotherapy regimen was DDP(40mg/m2,once a week) for all patients.[Results] Median follow-up for patients was 42 months.The overall survival(OS) rate was 79.3%.The 3year OS rate was 80.5% in test group and 76.2% in control group(P=0.937).The disease free survival(DFS) rate was 63.1% in test group and 57.9% in control group(P=0.653).The distance metastasis free survival(DMFS) rate was 68.2% in test group and 62.6% in control group(P= 0.692).The recurrence free survival(RFS) rate was 84.1% in test group and 74.4% in control group(P=0.345).Mucositis and leukopenia grade 3～4 were higher in test group than those in control group significantly(31.6% vs 9.1%,21.1% vs 5.5%,P0.05).[Conclusion] Induction chemotherapy followed by concurrent chemoradiotherapy could not improve the 3-year OS rate,DFS rate,DMFS rate and RFS rate in NPC patient stage T3～4N2～3M0 comparing with concurrent chemoradiotherapy alone.The benefits of induction chemotherapy followed by concurrent chemoradiotherapy for patients with NPC should be further investigated in large and random samples.

Association of p53 Codon72 Polymorphism and Risk of Hepatocellular Carcinoma

Abstract: [Purpose] To explore associations between p53 single nucleotide polymorphism(SNP) codon72 and risk of hepatocellular carcinoma(HCC) in Guangxi.[Methods] A hospital-based case-control study was conducted in 985 cases with HCC and 992 cancer-free matched controls.p53 codon72 genotypes(ArgPro,rs1042522) were detected by Applied Biosystems TaqMan genotyping platform.[Results] The variant genotypes of p53 codon72 did not significantly associate with risk of HCC(Arg/Pro:adjusted OR=1.15,95%CI:0.83～1.59;Pro/Pro:adjusted OR=1.16,95%CI:0.80～1.68;Arg/Pro+Pro/Pro:adjusted OR=1.15,95%CI:0.85～1.57).After stratified with smoking,alcohol drinking,HBV and HCV infections,no risk increasing genotype was found.However,interactions between p53 codon72 polymorphism and smoking,alcohol drinking and HBV infection might modify the risk of HCC [smoking(adjusted OR=2.42,95%CI:1.47～3.97),alcohol drinking(adjusted OR=2.96,95%CI:1.82～4.80) and HBV infection(adjusted OR=62.74,95%CI:34.39～114.46)].[Conclusion] p53 codon72 may not have the independent effect on the susceptibility to HCC.However,the interactions between p53 codon72 polymorphism and smoking,alcohol drinking and HBV infection might modify the risk of HCC.