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JournalISSN: 1570-0232

Journal of Chromatography B 

Elsevier BV
About: Journal of Chromatography B is an academic journal published by Elsevier BV. The journal publishes majorly in the area(s): High-performance liquid chromatography & Liquid chromatography–mass spectrometry. It has an ISSN identifier of 1570-0232. Over the lifetime, 11293 publications have been published receiving 332778 citations. The journal is also known as: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences & J. Chromatogr. B.

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Journal ArticleDOI
Abhinav A. Shukla1, Brian Hubbard1, Tim Tressel1, Sam Guhan1, Duncan Low1 
TL;DR: This paper describes the key elements of a flexible, generic downstream process platform for mAbs that has been adopted at Amgen and consists of a well-defined sequence of unit operations with most operating parameters being pre-defined and a small subset of parameters requiring development effort.

825 citations

Journal ArticleDOI
TL;DR: Several novel chemometric methods for evaluating the fingerprints of herbal products, such as the method based on information theory, similarity estimation, chemical pattern recognition, spectral correlative chromatogram (SCC), multivariate resolution, etc, are discussed in detail with examples, which showed that the combination of chromatographic fingerprints and the chemometric evaluation might be a powerful tool for quality control of herbal medicines.

723 citations

Journal ArticleDOI
TL;DR: In this review, the influence of matrix effects on bioanalytical LC-MS/MS methods is discussed and illustrated with some examples, and possible solutions to reduce or eliminate matrix effects are highlighted.

692 citations

Journal ArticleDOI
TL;DR: The combination of polymeric mixed-mode SPE, the appropriate mobile phase pH and UPLC technology provides significant advantages for reducing matrix effects resulting from plasma matrix components and in improving the ruggedness and sensitivity of bioanalytical methods.

680 citations

Journal ArticleDOI
TL;DR: The present article gives an overview of the currently available assays of nitrite and nitrate in biological fluids based on the Griess reaction, the most frequently used analytical approach to quantitate the major metabolites of NO, i.e. nitriteand nitrate, in a variety of biological fluids, notably blood and urine.

672 citations

No. of papers from the Journal in previous years