Showing papers in "Journal of Clinical Virology in 2011"

TL;DR: The online typing-tools reliably assign genotypes for enterovirus type or norovirus genotype and/or variant, with profile alignment, construction of phylogenetic trees and bootstrap validation makes these tools robust to ongoing evolution.

TL;DR: Cell culture experiments support the thesis that vitamin D has direct anti-viral effects particularly against enveloped viruses and suggest it may be linked to vitamin D's ability to up-regulate the anti-microbial peptides LL-37 and human beta defensin 2.

TL;DR: The risk of intrauterine transmission following primary maternal infection in the third trimester is high, but the risk of neonatal disease is low, according to a prospective cohort study of pregnancy outcome in relation to gestational age at primary maternal CMV infection.

TL;DR: It is demonstrated that Mashhad still remains an endemic area for HTLV-I infection despite routine blood screening, and further strategies are needed for prevention of the virus transmission in whole population.

TL;DR: The suggested role of undercooked pig products in food as a source of zoonotic HEV infection for humans remains to be clarified if this mechanism of transmission is responsible for the surprisingly high anti-HEV IgG prevalence recently observed in some European countries and the USA.

TL;DR: Ribavirin therapy could be an effective treatment of severe acute hepatitis E in a non-immunocompromized patient.

TL;DR: The results indicate that HPV is common among oropharyngeal and oral cavity carcinoma cases in France and emphasize the predominance of HPV 16.

TL;DR: The serology showed no evidence for a causative role of MCPyV in lower respiratory tract infection manifesting as acute wheezing, but was compatible with the notion of M CPyV persistence in tonsils.

TL;DR: Improved sensitivity is demonstrated of the alternative algorithm for detecting acute HIV-1 infections, while maintaining the ability to accurately detect established HIV-2 infections and turn-around time is reduced.

TL;DR: In the majority of patients after short-term treatment with telaprevir or boceprevir wild-type NS3-protease isolates are detectable by clonal sequencing at long-term follow-up, and Detectable resistance mutations in single patients are not predictable by initial frequencies of variants.

TL;DR: In this paper, the role of prenatal diagnosis and counseling in the management of pregnancy complicated by primary HCMV infection was assessed, and the overall rate of vertical transmission was 37.1%, ranging from 5.6% for preconceptional infections to 64.1% for third trimester infections.

TL;DR: It is emphasized that occupational blood exposure is of great concern in developing countries, with higher risk of exposure to blood-borne viruses because of a higher prevalence of the latter than in developed countries, re-use of needles and syringes and greater risk of sustaining PI, since injection routes are more frequently used for drug administration than in develop countries.

TL;DR: This one-step nucleic acid-based assay enables rapid, sensitive and specific detection of the major viral causes of gastroenteritis and is informative for clinical research particularly in the context of mixed infections.

TL;DR: Use of Ag/Ab combination assays may improve the number of AHIs identified relative to existing FDA-approved HIV-antibody only based serologic assays, particularly in high incidence populations.

TL;DR: An increase of EV68 infections is noticed and clinical as well as sequence data is presented, in which two distinct phylogenetic clusters could be identified.

TL;DR: This real-time RT-PCR assay had a sensitivity of 50 genomic copies per reaction and 1 PFU/ml of USUV isolate and is recommended for all cases in which a rapid and clinically accurate diagnosis of human USUV infection is required.

TL;DR: A mature sequence of MCV-miR-M1 found in vivo was identical in all 79 reads obtained but differed from the in silico predicted mature miRNA by a 2-nucleotide shift, resulting in a distinct seed region and a different set of predicted target genes.

TL;DR: The RealTime HCV assay is suitable for monitoring virologic response to PEG-INF/RBV therapy and tailoring treatment duration accordingly.

TL;DR: The xTAG PRV showed increased sensitivity to common viral targets represented in the assays, and also had the ability to differentiate human from non-human influenza A H1.

TL;DR: HCV Ag positivity anticipated anti- HCV seroconversion in all three cases of acute hepatitis C and may be used as reflex testing on anti-HCV positive individuals to confirm or exclude an active infection, and on subjects with acute hepatitis or belonging to high risk groups.

TL;DR: Using a simple dilution algorithm, the quantitative Elecsys HBsAg II assay reliably determined serumHBsAg levels in a wide range of samples, and showed very high correlation with the Architect HBs Ag assay.

TL;DR: The first case of successful eradication of disseminated adenovirus infection by the novel antiviral agent CMX001 in a severely immunocompromised pediatric stem cell transplant recipient following failure to respond to intravenous cidofovir is reported.

TL;DR: The IgG antibody response to the pentameric complex could be a major target for the evaluation of the antibody response in both primary and reactivated HCMV infections.

TL;DR: In this article, the authors quantified the disease burden of respiratory viruses in hospitalized patients using the World Health Organization endorsed DALY model and found that Adenovirus was among the leading cause of respiratory presentations in children but not adults.

TL;DR: This multiplex showed excellent specificities for all 14 respiratory viruses and sensitivity was high except for clinical samples with low levels of enterovirus, and no competition was observed when different targets were present at different amounts in one tube.

TL;DR: NGS is a promising method for HPV typing because of its high sensitivity in multiple infection and its potential ability to detect a broad spectrum of HPV types, subtypes, and variants.

TL;DR: A case of acute necrotizing pancreatitis associated with imported acute viral E hepatitis (genotype 1a) in a 26 years old French man travelling and originated from Pakistan is reported.

TL;DR: This review discusses how clinical virology laboratories have handled diagnosis of oseltamivir-resistant H1N1 and what they have learned from clinical studies and case series.

TL;DR: The antiviral drugs ganciclovir, foscarnet and cidofovir have proven to be efficient against AIs and related diseases but the indications and conditions of their use are not yet formally approved, emphasizing the need for controlled studies addressing both the clinical impact and therapy of HHV-6 AIs.

TL;DR: It is important to monitor more carefully the EV-71 strains circulating in France to detect the introduction of new genetic variants that could be associated with major outbreaks.