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Showing papers in "Journal of Controlled Release in 1991"


Journal ArticleDOI
TL;DR: In this paper, a new rationale of preparing pH-sensitive hydrogels based on thermally reversible polymers is proposed, according to which a new class of hydrogel has been synthesized.

417 citations


Journal ArticleDOI
TL;DR: In this article, the degradation mechanism of LA/GA-polymers in solid state has been investigated and it is shown that intrinsically amorphous members of the family and quenched semi-crystalline ones can crystallize while degrading.

290 citations


Journal ArticleDOI
TL;DR: A general survey of the manufacturing methods of microspheres and microcapsules based on biodegradable polyesters, including polylactides, polyglycolide, polyhydroxybutyrate, polycaprolactone, polycarbonates and related copolymers is presented in this paper.

282 citations


Journal ArticleDOI
TL;DR: In this paper, the authors present methods of preparation of strong poly(vinyl alcohol) hydrogels without utilization of chemical crosslinking or reinforcing agents and discuss biomedical and pharmaceutical applications of these gels.

279 citations


Journal ArticleDOI
TL;DR: These concepts of Lipid-Protein-Partitioning theory of skin penetration enhancement are discussed, quoting examples of the three mechanisms as assessed by differential scanning calorimetry and permeation studies and relates such investigations to ideas of the molecular architecture of the stratum coraeum.

274 citations


Journal ArticleDOI
TL;DR: In this paper, the swelling behavior of interpenetrating polymer networks (IPN) composed of poly(acrylic acid) (PAAc) and poly (acrylamide(AAm)-co-butyl methacrylate (BMA)) in water was studied and compared to crosslinked poly(AAcco-AAm-co-BMA) and crosslinked polymorphic gels (random gels) with the same monomer compositions as the IPNs.

209 citations


Journal ArticleDOI
TL;DR: These nanoparticles improved the antibody response and the protection against challenge with life virus in comparison to the classical adjuvant aluminium hydroxide using influenza as a model antigen.

205 citations


Journal ArticleDOI
TL;DR: In this paper, a multunit floating device for use in the stomach by the emulsion-solvent diffusion method was prepared by using tranilast, an oral anti-allergic agent, embedded in the shell of the microballoon.

188 citations


Journal ArticleDOI
TL;DR: New ultrastructural methods complement powerful physical-chemical methods together providing precise information about the structure and molecular architecture of stratum corneum intercellular domains, and epidermal lipid synthesis is regulated by barrier requirements, and transepidermal water loss appears to be a regulatory factor.

175 citations


Journal ArticleDOI
TL;DR: These findings contradict the suggestion that ethanol “disorders” the intercellular lipid bilayers of the stratum comeum and reveal that ethanol enters the skin and removes measurable quantities of the barrier material.

174 citations


Journal ArticleDOI
TL;DR: The results indicate that the intercellular route of transport through the stratum corneum predominates, but that after longer transport times, apical corneocytes tend to take up material, leading to a bimodal distribution of mercury.

Journal ArticleDOI
TL;DR: The physicochemical properties of progesterone-loaded poly(l-lactide) microspheres prepared by the solvent evaporation method were studied, focusing on the crystallinity of the polymer matrices as discussed by the authors.

Journal ArticleDOI
TL;DR: Graft copolymers of poly (ethylene glycol) with poly(methacrylic acid) were prepared by reaction of poly(ethylene girders) methacrylate macromonomer with methacric acid in the presence of tetraethylenes glycol dimethacrylated as a crosslinking agent as discussed by the authors.

Journal ArticleDOI
TL;DR: In this article, the effects of controllable network parameters on the important properties (degree of swelling, transition temperature and sharpness of transition) of the gels obtained were investigated. But the results were limited to a limited temperature range.

Journal ArticleDOI
TL;DR: The effect of water and propylene glycol on the physical-chemical properties of the human stratum corneum has been studied with small angle X-ray scattering (SAXS) and differential thermal analysis (DTA) as discussed by the authors.

Journal ArticleDOI
TL;DR: The current results verify the previous findings that the drug loading has a definite effect on the drug release mechanism from hydrogels and show that the swelling maximum in the transient dimensional changes can be qualitatively predicted.

Journal ArticleDOI
TL;DR: The data demonstrate that biological rhythms have to be taken into account when evaluating drug delivery systems, galenic formulations and pharmacokinetics as a basis for drug treatment.

Journal ArticleDOI
TL;DR: In this paper, microspheres containing bovine serum albumin (BSA) were pre-pared with and without Carbopol® 951 (a potential adjuvant agent) by o/o, o/w and (w/o) /w emul-sion methods.

Journal ArticleDOI
TL;DR: The analysis of the data indicates that an anomalous release mechanism controls the transport of the drug; this includes neither Fickian diffusion nor glassy/rubbery transition.

Journal ArticleDOI
TL;DR: To overcome the problem of biphasic release profiles of parenteral depot systems, novel biodegradable terpolymers are synthesized from various core-molecules by grafting PLG on appropriate functionalities, which have physico-chemical and degradation properties differing from linear PLG.

Journal ArticleDOI
TL;DR: In this paper, a crosslinked polymer, poly(2-acrylamido-2-methylpropane sulfonic acid-co-n-butylmethacrylate) [poly (AMPS/BMA), was synthesized to study the effect of electric current on solute release.

Journal ArticleDOI
TL;DR: The development of the dosage form is outlined and includes methods which may prove advantageous for the delivery of potent biologically active agents, such as those produced by contemporary biotechnological methods.

Journal ArticleDOI
TL;DR: Physico-chemical properties and characterization of biodegradable nanoparticles, as well as drug payload, are discussed and special attention is given to the mechanism of bioerosion of nanoparticles both in vitro and in vivo.

Journal ArticleDOI
TL;DR: In this article, the effect of the enhancer on stratum corneum (SC) barrier function and percutaneous penetration enhancement has been investigated using differential scanning calorimetry and infrared spectroscopy.

Journal ArticleDOI
TL;DR: In vitro diltiazem hydrochloride release profiles that were zero-order and pH-independent were obtained without chemical modification of the drug and these approaches may be applied in general to extend osmotic pump technology to drugs with intrinsic water solubilities that are too high or low for conventional osmosis pump formulations.

Journal ArticleDOI
TL;DR: In this article, the crosslinked structure of ionic hydrogels in contact with water is analyzed and the equilibrium swelling ratio or equilibrium polymer volume fraction is shown to be a function of the polymer compatibility (as determined by the χ 1 factor), polymer structural parameters and the ionic nature of the hydrogel.

Journal ArticleDOI
TL;DR: Pseudoephedrine HCl, a highly water-soluble drug, was entrapped within polymeric microspheres by either an oil-in-water (dispersion or cosolvent method) or a water-inoil-inwater (multiple emulsion method) emulsion-solvent evaporation method as discussed by the authors.

Journal ArticleDOI
TL;DR: The results show that GRF can be associated with biodegradable poly(alkylcyanoacrylate) nanoparticles and the alkyl chain length of the cyanoacrylic polymer was able to modulate the rate of GRF release.

Journal ArticleDOI
TL;DR: It was found that free drug at equivalent dose was also effective against Walker sarcoma in vivo and the therapeutic index of polymer conjugated drug was not appreciably greater than that of the free drug and was dependent on the dosing regime.

Journal ArticleDOI
TL;DR: In this paper, controlled release polymeric implants may improve delivery of anti-edema agents to the central nervous system, and high performance liquid chromatography was used to quantify tissue concentrations after implantation of the drug-loaded polymer or intraperitoneal injection of an equivalent dose.