Showing papers in "Journal of Controlled Release in 2000"

TL;DR: The basic characteristics of the EPR effect, particularly the factors involved, are described, as well as its modulation for improving delivery of macromolecular drugs to the tumor.

TL;DR: Dendrimers are highly branched macromolecules of low polydispersity that provide many exciting opportunities for design of novel drug-carriers, gene delivery systems and imaging agents but it is clear that dendrimer structure must also be carefully tailored to avoid rapid hepatic uptake if targeting elsewhere (e.g. tumour targeting).

TL;DR: Experiments using fluorescent probes and ultracentrifugation showed that the ethosomes had a high entrapment capacity for molecules of various lyophilicities, including testosterone from an ethosomal patch was greater both in vitro and in vivo than from commercially available patches.

TL;DR: In this review, the current technological developments of FDDS including patented delivery systems and marketed products, and their advantages and future potential for oral controlled drug delivery are discussed.

TL;DR: Two model drugs, ketoprofen and spironolatone, which have different hydrophobicities, were released from the PEG-PLGA-PEG triblock copolymer hydrogel formed in situ by injecting the solutions into a 37 degrees C aqueous environment.

TL;DR: A new hyaluronic acid (HA)-based hydrogel film was prepared and evaluated for use in drug delivery and can be employed for controlled release of therapeutic agents at wound sites.

TL;DR: A remarkable improvement in blood circulation of DOX was achieved by use of PEG-PBLA micelle as a carrier presumably due to the reduced reticuloendothelial system uptake of the micelles through a steric stabilization mechanism.

TL;DR: The results suggest that these matrices could serve as therapeutic materials to enhance peripheral nerve regeneration through nerve guide tubes and may have more general usefulness in tissue engineering.

TL;DR: A gas foaming polymer processing approach is developed that allows the fabrication of three-dimensional porous matrices from bioabsorbable materials without the use of organic solvents or high temperatures, and the fabrication process allows incorporation under mild conditions.

TL;DR: Five new polyethylenimines (PEI) were synthesized by polymerization of aziridine in aqueous solution and compared to several commercially available PEI used for gene transfer to gain insight into structural and functional properties.

TL;DR: A good correlation between polymorphic transitions and increased drug release was observed in this study and was often related to the metastable beta' polymorph.

TL;DR: Structural deformations produced by outer shell polymer structural change with temperature cycles through the LCST are proposed for the PBMA core possessing a lower T(g) than the outer shell PIPAAm LCST, while the PSt core retained its structure, regardless of outer shell changes.

TL;DR: The results suggest that these matrices could serve as therapeutic materials to enhance peripheral nerve regeneration through nerve guide tubes and may have more general usefulness in tissue engineering for the delivery of non-heparin-binding growth factors.

TL;DR: Animal and human studies have shown that both the distribution and elimination of dextrans are dependent on the M(W) and charge of these polymers, and future studies should concentrate on barriers for the clinical use ofdextrans as macromolecular carriers for delivery of drugs, proteins, and imaging agents.

TL;DR: In this paper, dendritic unimolecular micelles with a hydrophobic core surrounded by hydrophilic shell were prepared by coupling dendicle hypercores with poly(ethylene glycol) [PEG] mesylate.

TL;DR: Freeze-dried membranes could serve as potent candidates for antibiotic delivery in an acidic environment and had superior drug-release properties to air-d dried hydrogels.

TL;DR: In vivo anti-tumor activity assay showed that a single injection of the nanoparticles had comparable activity to that of free doxorubicin administered by daily injection, potentially useful for the formulation of nanoparticles that requires targeting for cancer cells as well as sustained release at the site.

TL;DR: The PCL-b-PEO micelles were found to have a high loading capacity for DHT and the release profile of the drug from the micelle solution was found to be a slow steady release which continued over a 1-month period.

TL;DR: Experimental results indicate that the chain interpenetration is a strong function of the PEG molecular weight, the polymer swelling ratio and the mucosa composition.

TL;DR: The increased transdermal drug delivery from microemulsion formulations was found to be due mainly to the increased solubility of drugs and appeared to be dependent on the drug mobility in the individual vehicle.

TL;DR: This paper describes the synthesis, physico-chemical characteristics and results of selected biological tests of conjugates of antibodies or proteins with poly(HPMA) or withpoly( HPMA) carriers of anti-cancer drug doxorubicin, designed for targeted cancer therapy.

TL;DR: Encapsulation of paclitaxel in conventional liposomes produced marked differences over the free drug pharmacokinetics, which led to a considerable decrease in drug uptake in MPS-containing organs (liver and spleen) after injection with PEGylated compared to conventionalliposomes.

TL;DR: Active delivery studies with fluorescein indicated that Three Dimensional Printing is capable of accurately constructing dosage forms with active content as low as 10(-12) moles per tablet.

TL;DR: It is suggested that preparation temperature significantly affects microsphere formation, resulting in their structural and protein release profile differences, which ultimately work together to affect the initial release and overall release patterns of the microspheres.

TL;DR: In this short communication, the roles of electrorepulsion and electroosmosis have been reconsidered from a simple theoretical point of view, and experimental approaches by which their relative importance may be estimated have been proposed and subjected to initial evaluation.

TL;DR: The area of bio-adhesion in drug delivery had started some 20 years ago by using so-called muco-adhesive polymers Many of these polymers were already used as excipients in pharmaceutical formulations This has facilitated the development of the first bioadhesive drug products, which are now commercially available as discussed by the authors.

TL;DR: The combination of HA with chitosan may afford additional advantages in combining the mucoadhesive potential ofHA with the penetration enhancing effect of chitan, and thereby improve the resultant pharmacokinetic profile.

TL;DR: A specific formulation, 1.6% zinc insulin in poly(lactide-co-glycolide) (PLGA) with fumaric anhydride oligimer and iron oxide additives has been shown to be active orally and able to control plasma glucose levels when faced with a simultaneously administered glucose challenge.

TL;DR: The results demonstrated that the carbopol/pluronic mixture can be used as an in situ gelling vehicle to enhance the ocular bioavailability.

TL;DR: The potential of these unimolecular polymeric micelles to release a drug for an extended time is investigated using lidocaine as a model drug for in vitro studies using a horizontal diffusion cell and cellulose membrane.