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Showing papers in "Journal of Controlled Release in 2001"


Journal ArticleDOI
TL;DR: This review presents the most outstanding contributions in the field of biodegradable polymeric nanoparticles used as drug delivery systems from 1990 through mid-2000.

3,284 citations


Journal ArticleDOI
TL;DR: The review concentrates on the use of polymeric micelles as pharmaceutical carriers and the basic mechanisms underlying micelle longevity and steric protection in vivo are considered with a special emphasis on long circulating drug delivery systems.

1,670 citations


Journal ArticleDOI
TL;DR: Experimental observations of burst release in monolithic polymer controlled drug delivery systems, theories of the physical mechanisms causing burst, some of the unique ideas used to prevent burst, and the treatment of burstRelease in controlled release models are reviewed.

1,518 citations


Journal ArticleDOI
TL;DR: The chitosan-DNA nanoparticles could partially protect the encapsulated plasmid DNA from nuclease degradation as shown by electrophoretic mobility analysis and three different schemes to conjugate transferrin or KNOB protein to the nanoparticle surface were developed.

1,201 citations


Journal ArticleDOI
TL;DR: The general mechanism of the EPR (enhanced permeability and retention) effect and factors involved in the effect are discussed, in view of the advantages of macromolecular therapeutics for cancer treatment, which are based on the highly selective EPR-related delivery of drug to tumor.

876 citations


Journal ArticleDOI
TL;DR: Preliminary studies showed the feasibility of chitosan nanoparticles to entrap the basic drug DOX and to deliver it into the cells in its active form.

704 citations


Journal ArticleDOI
TL;DR: The results of cytotoxicity, MTD, LD(50) and antitumor efficacy suggest that Genexol-PM may have a great advantage over present-day chemotherapy with Taxol.

673 citations


Journal ArticleDOI
TL;DR: The results suggest that encapsulation of the conjugate in nanoparticles not only reduces the side effects, but also improves its therapeutic efficacy in the treatment of solid tumors.

626 citations


Journal ArticleDOI
TL;DR: ReGel's inherent ability to solubilize (400 to >2000-fold) and stabilize poorly soluble and sensitive drugs, including proteins is a substantial benefit and the gel provided excellent control of the release of paclitaxel for approximately 50 days.

566 citations


Journal ArticleDOI
TL;DR: The result of pre-clinical study of NK911, a polymeric micelle carrier system for doxorubicin (DOX) shows much stronger activity than the free DOX, which can entrap the sufficient amount of DOX in tumor tissue by EPR effect.

566 citations


Journal ArticleDOI
TL;DR: PEGylated poly(lactic-co-glycolic acid) (PEG-PLGA) nanoparticles could be an effective carrier for PPD delivery and obviously change the protein biodistribution in rats compared with that of PLGA nanoparticles.

Journal ArticleDOI
Hyuk Sang Yoo1, Tae Gwan Park1
TL;DR: The cytotoxic activity of the micelles against HepG2 cells was greater than free doxorubicin, suggesting that the miceLLes containing conjugated doxorbicin were more effectively taken up cellularly, by an endocytosis mechanism rather than by passive diffusion.

Journal ArticleDOI
TL;DR: It is demonstrated that a surface-modulated PEG-PDLLA micelle with a suitable size and a narrowly distributed nature has promising potential as a long-circulating carrier system with desirable biocompatibility and biofunctionality.

Journal ArticleDOI
Dan E. Meyer1, B.C. Shin1, G.A. Kong1, Mark W. Dewhirst1, Ashutosh Chilkoti1 
TL;DR: The results suggest that enhanced delivery of drugs to solid tumors can be achieved by conjugation to thermally responsive polymers combined with local heating of tumors.

Journal ArticleDOI
TL;DR: The ability of several cell lines to internalise labelled polystyrene microsphere of different sizes is characterized and a good correlation was found between the uptake of 560-nm microspheres and the uptakeof a peptide-DNA polyplex formulation, when it was prepared under conditions leading to small particle sizes.

Journal ArticleDOI
TL;DR: Good potential of structurally diverse polyplex systems as transfection reagents with relatively low cytotoxicity is demonstrated.

Journal ArticleDOI
TL;DR: It is found that dipalmitoyl-phosphatidylcholine (DPPC) can provide more complete coating on the surface of the products which thus results in a higher emulsifying efficiency compared with polyvinyl alcohol (PVA).

Journal ArticleDOI
TL;DR: A new chemical cross-linking scheme was utilized for the formation of degradable poly(ethylene glycol) hydrogels suitable for the delivery of protein drugs, and it was observed that about 65% of the incorporated protein was released with zero-order kinetics over a period of about 4 days.

Journal ArticleDOI
TL;DR: This recent resuscitation of small organic molecule delivery by high molecular weight PEG conjugates was founded on meaningful in vivo testing using established tumor models, and has led to a clinical candidate.

Journal ArticleDOI
TL;DR: A mutant VEGF(121) variant, alpha(2)-PI(1--8)-VEGF(121), which contains an additional factor XIIIa substrate sequence NQEQVSPL at the aminoterminus, was expressed in E. coli and its covalent incorporation and the efficiency of incorporation into fibrin was demonstrated and characterized.

Journal ArticleDOI
TL;DR: A method for producing microspheres of precisely controlled and/or monodisperse size distributions and may allow development of advanced controlled-release delivery systems is developed.

Journal ArticleDOI
TL;DR: Anti-HER2 ILs, but not non-targeted liposomes, achieve intracellular drug delivery via receptor-mediated endocytosis, and this mechanism is associated with superior antitumor activity.

Journal ArticleDOI
TL;DR: The polar model drug Rose Bengal was successfully loaded into the nanoparticles during production and the surface of these particles was subsequently modified with poloxamer 407 and poloxamine 908 in order to create a steric stabilising layer of PEG on the surface.

Journal ArticleDOI
TL;DR: In vivo anti-tumor activity of conjugates containing hydrolytically sensitive linkage was also significantly improved in mouse EL4 T cell lymphoma and Cytotoxicity of conjugs was much higher compared with the effect of similar 'classic' conjugate bearing Dox attached via amide bond.

Journal ArticleDOI
TL;DR: Plasmid DNA can be very efficiently encapsulated, either in a free form or in combination with PVP and PVA, into PLA-PEG nanoparticles and depending on the processing conditions, these nanoparticles release plasmidDNA either very rapidly or in a controlled manner.

Journal ArticleDOI
TL;DR: The formulation and evaluation of an ophthalmic delivery system of an antibacterial agent, ofloxacin, based on the concept of pH-triggered in situ gelation is described, which was therapeutically efficacious, stable, non-irritant and provided sustained release of the drug over an 8-h period.

Journal ArticleDOI
TL;DR: The differential scanning calorimetry (DSC) result indicated that the paclitaxel trapped in the microspheres existed in an amorphous or disordered-crystalline status in the polymer matrix.

Journal ArticleDOI
TL;DR: A better understanding of microcirculatory barriers in solid tumors is obtained and novel strategies to exploit and/or to overcome these barriers for improved cancer detection and treatment are developed.

Journal ArticleDOI
TL;DR: The incorporation of lactose, albumin and DPPC in the formulation all improved the aerosolization properties, in contrast to trehalose and the mannitol which decreased powder flowability.

Journal ArticleDOI
TL;DR: It is concluded that phagocytosis activity of DCs and MPhis largely depends on particle size and surface charge and is also influenced by the character of bulk and coating material.