Showing papers in "Journal of Critical Care in 1996"

TL;DR: P(t-a)CO2 is a more reliable index of gastric oxygenation than is pHi alone or pH(ap-i, however, it was further shown that pH(AP-i) can be associated with a wide range of P( t-a-CO2, depending on the magnitude of pH( ap-i), and on the PaCO2 at which P(t)-a) CO2 is measured.

TL;DR: ITBV, therefore, shows potential as a clinically useful indicator of overall cardiac preload and the possibility that ITBV might be cardiac output-dependent was not supported.

TL;DR: The lungs of patients with sepsis and ARDS may produce lactate and pulmonary lactate release correlates with the severity of lung injury, which should be considered when interpreting arterial lactate concentration as an index of systemic hypoxia.

TL;DR: It is concluded that reported practice patterns regarding the care of ARDS patients vary widely even within a relatively homogenous group of critical care practitioners.

TL;DR: PROM results in no significant changes in ICP or CPP in stable, neurosurgical patients in the absence of intracranial hypertension.

TL;DR: There are substantial differences in cardiac output as measured by these three methods and the variability of cardiac output and its derivatives should be borne in mind when making clinical decisions on individual patients.

TL;DR: Changes in vascular tone during endotoxemia are dependent on volume status, and the increased cardiac output in volume-treated septic animals occurred because of an increase in stressed volume due to the volume given in combination with a dilated vasculature.

TL;DR: In the pericardectomized rabbit, increases in RV ED volume decrease LV ED volume by decreasing LV diastolic compliance, but do not alter LV systolic function, while in the open-pericardium intact animal model, this effect is offset by an increase in RV maximal elastance, but minimally alter RV diastolics function.

TL;DR: The results suggest that exhaled NO accurately reflects changes in arterial serum NO concentration and that the source of enhanced NO release in acute endotoxemia is not the iNOS isoform.

TL;DR: Poor reproducibility of individual pHi determinations may limit the accuracy of pHi obtained by gastric balloon tonometry in the clinical setting, as Clinically important disagreement was observed in simultaneous p Hi determinations obtained using separate gastric balloons exposed to identical in vivo conditions.

TL;DR: It is concluded that although L-NAME at 30 mg/kg causes vasoconstriction, its effects on coronary blood flow and LV function were not significant, and NG-nitro-L-arginine did not alter Mvo2 in either endotoxemic or nonendotoxemic animals.

TL;DR: These data show that during PLV in this normal animal model, effective gas exchange is sustained and CT decreases with increasing perflubron dose.

TL;DR: Novel therapies aimed at minimizing further organ dysfunction may improve outcome in a cost-effective fashion by preventing both further primary organ dysfunction or remote organ dysfunction secondary to the subsequent activation of the inflammatory response.

TL;DR: It is concluded that CPAP can produce increases in CO when the heart is distended whether baseline LV function is relatively normal (HV) or depressed (CHF); and there are probably a number of different mechanism increasing CO with CPAP and these may vary from condition to condition.

TL;DR: The results suggest that Ca(2+)-regulatory mechanisms may be disrupted in the acute trauma patient and calciuria observed was inappropriate in the context of ionized hypocalcemia.

TL;DR: Monoclonal antibodies to CD18 can prevent the deterioration in cardiac function routinely observed following cardiopulmonary bypass, and are found to bound essentially all neutrophil CD18 sites.

TL;DR: Examination of the effects of 30 mg/kg of the NO synthase inhibitor NG-nitro-L-arginine-methyl ester to those of 300mg/kg to assess the effects on coronary ischemia and myocardial function found L-NAME caused a rise in MAP and systemic vascular resistance; however, it had no effect on ventricular function.

TL;DR: According to the lung model, continuous-flow administration of NO near the endotracheal tube is influenced strongly by changes in ventilatory settings, and the addition of dead space enhanced these differences.

TL;DR: Exogenous increases in blood [K+] potentiate skeletal muscle contraction in intact animals and reverse low-frequency twitch fatigue, a possible mechanism may be the maintenance of intracellular K+ by hindering K+ efflux from skeletal muscle cells.

TL;DR: Most patients with nosocomial pneumonia had no associated intramucosal gastric acidosis, however, low pHi was associated with increased mortality, and there were significant differences when tonometer PtCO2 values of both groups were compared.

TL;DR: Pre-clinical data indicate that IL-6 antibodies may abrogate the effects of endotoxin infusion, but no human studies have been performed, and the ultimate effectiveness of which will need to be proven in large randomized clinical trials.

TL;DR: The results suggest that the nondiuretic affects of furosemide cannot explain its purported clinical utility in ARDS, which results in the absence of effective kidney function and multiple organ failure.

TL;DR: Results indicate that alpha-adrenoreceptor activation may increase the tension generated by the diaphragm as well as its oxygen consumption and oxygen extraction, which may compromise the development of delivery limitation of VO2di and compromise the ability to sustain ventilation.

TL;DR: The decreases in pulmonary and systemic vascular resistance, pulmonary impedance, and cardiac function associated with BD are not related to major changes in the NO pathway.

TL;DR: An important element of the management of septic shock is the correction of any component of these other forms of shock: cardiac output should be supported as early in the course of septic shock as possible by infusion of appropriate amounts of intravenous fluids and the judicious use of inotropic agents.