Showing papers in "Journal of Critical Care in 1997"

TL;DR: In this relatively small group of patients presenting with an established ARDS subsequent to a variety of underlying diseases, intravenous N-acetylcysteine treatment during 72 hours neither improved systemic oxygenation nor reduced the need for ventilatory support.

TL;DR: Although IL-10 has an inhibitory effect on the production of cytokines, it is released together with TNF and IL-6 in patients with septic shock and directly related to the severity of inflammation and the development of organ failure in septicshock.

TL;DR: In patients undergoing major surgery, volume resuscitation with hydroxyethyl starch solutions may improve microvascular blood flow and tissue oxygenation and there were no significant differences in hemodynamic- and oxygenation-derived variables or coagulations between the two groups of patients.

TL;DR: Dobutamine prevented arteriolar constriction and maintained villus blood flow at preendotoxemic values in rats with normotensive endotoxemia, and blood flow in intestinal villi were reduced.

TL;DR: It is suggested that circulating BNP plays an important role in acute lung injury along with ANP as a compensatory mechanism for cardiac dysfunction accompanied by increased systemic vascular resistanceIndex and pulmonary vascular resistance index.

TL;DR: DNR protocols do not prevent CPR being performed on patients who are unlikely to survive to hospital discharge, and CPR should only be offered to patients whose initial rhythm was either ventricular tachycardia or fibrillation.

TL;DR: It is concluded that during early endotoxemia in the dog, the gut is a major site of metabolic acid removal and the gut significantly increased metabolic acid uptake.

TL;DR: Findings give further evidence that also in humans, heat shock response is activated during sepsis and suggests that HSP70 exerts a possible protective effect against TNF-alpha cytotoxicity.

TL;DR: Positive pressure inspiration induces time-dependent changes in central hemodynamics, which are dissimilar between RV and LV function, and data suggest that positive pressure ventilation with up to 20 cm H2O P(aw) does not significantly impair ventricular performance in humans.

TL;DR: The results indicate that i.v. anesthetics decrease ICP caused by SOL but have no significant effect on ICP due to CBE, while in the CBE model, none of these agents resulted in a significant change in either ICP or CPP.

TL;DR: The extent to which patients at high risk of hospital death who undergo cardiopulmonary resuscitation (CPR) have previously had their life support preferences addressed and documented was determined.

TL;DR: The reliability of PtCO2 measurements with either method improved with the use of ranitidine to maintain gastric fluid pH > or = 5.0, and measures of Pt CO2 with the air tonometer method are similar to those obtained with saline tonometry.

TL;DR: It is concluded that signs of tissue hypoperfusion started to develop at 70% SMA occlusion and that regional tissue hyp operfusion in the splanchnic region may develop without any systemic signs of oxygen supply/demand mismatch.

TL;DR: In patients after coronary artery bypass grafting, changes in intrathoracic intravascular fluid volumes during weaning are restricted to the period of T-piece breathing and reflect an increased venous return.

TL;DR: It is concluded that PSV delivered by MRV may adequately ventilate patients with moderate to severe ARDS, preserving gas exchange and hemodynamics, at least for the short period tested.

TL;DR: Although the accuracy of fiberoptic SvjO2 determination is limited, it allows the detection of cerebral blood flow and oxygen supply-demand imbalance during aneurysm surgery and is suggestive of reactive hyperemia mechanisms.

TL;DR: The observed different effect of PEEP on CI in patients with and without heart failure persists after the elimination of secondary effects due to underlying differences in Ctp, oxygenation, and breathing effort; and PEEP-related changes in CTP should be taken into consideration when dealing with the cardiovascular effects of PEP.

TL;DR: It is suggested that a decrease in GFR caused by live bacteria in the circulation may benefit from fluid resuscitation, while during endotoxemia this therapy could not prevent acute renal failure.

TL;DR: The approach so far has been to lump together large numbers of critically ill septic patients to facilitate the rapid progression of the clinical trial, often with the hope that a posthoc analysis of the data will identify the type(s) of patients who are most likely to benefit from the intervention.

TL;DR: Although TNFR:Fc and its idiotypic control IgG1 reduced circulating bioactive TNF-alpha, neither treatment prevented progression of lethal shock with attendant organ injury in this conscious, antibiotic-treated and fluid-resuscitated model of immunosuppression-related GNB.

TL;DR: It is concluded that TGI increases carbon dioxide elimination efficiency during constant and decreased minute ventilation conditions without any evidence of hyperinflation or hemodynamic instability during methacholine-induced bronchospasm.

TL;DR: Four days of positive pressure ventilation decreases lung compliance and worsens gas exchange by increasing shunt and VA/Q mismatch in healthy baboons, accompanied by only minor ultrastructural changes and mild inflammatory responses in the lung.

TL;DR: Data suggest that factors other than organ injury, as assessed by morphological and permeability alterations, are important in the pathogenesis of altered systemic organ Vo2-Do2 relationships after LPS.

TL;DR: Data indicate that I/R injury is insufficient to account for the systemic organ VO2-DO2 alterations that occur with LPS injury, and the VO2 at the critical DO2 was markedly decreased in the I/ R group compared with that of the LPS group.

TL;DR: A modified postextubation management protocol, consisting of fewer interventions, resulted in significant patient charge savings with no increased risk to the patient.

TL;DR: Some of the principles guiding the use of economic analysis in medicine are reviewed, the cost of intensive care therapies are examined, and the ethics of using economics to ration care is discussed.

TL;DR: A practical ex vivo ABG monitor has been developed that offers accurate data and potential advantages to the critical care practitioner and the critically ill patient over other ABG analysis systems.

TL;DR: Infected ICU patients display a deficiency of phagocytosis membrane receptors of blood granulocytes and monocytes, and the addition of IVIG to standard therapy does not improve thephagocytic activity of intensive care unit (ICU) patients with nosocomial pneumonia.