Journal of Drug Delivery and Therapeutics 

About: Journal of Drug Delivery and Therapeutics is an academic journal published by Society of Pharmaceutical Tecnocrats. The journal publishes majorly in the area(s): Medicine & Chemistry. It has an ISSN identifier of 2250-1177. It is also open access. Over the lifetime, 3030 publications have been published receiving 10506 citations.

Estimation of total flavonoids content (tfc) and anti oxidant activities of methanolic whole plant extract of biophytum sensitivum linn

Abstract: Biophytum sensitivum linn. (Oxalidaceae), is an important and widely used medicinal plant. Biophytum sensitivum linn. is used as a traditional folk medicine in ailments such as inflammation, arthritis, wounds, tumors and burns, gonorrhea, stomach ache, asthma, cough, degenerative joint disease, urinary calculi, diabetes, snake bite, amenorrhea and dysmenorrhea.. The total flavonoid content of methanolic whole plant extract of B. sensitivum (MEBS) was determined by using aluminium chloride colorimetric method. Flavonoid compounds were found to be 9.49 µg of quercetin equivalent [QE] per mg of methanolic whole plant extract of Biophytum sensitivum. In this study phytochemical analysis of methanolic extract of B. sensitivum L. has indicated the presence of flavonoid . Since these compounds are of pharmacological interest, coupled with the use of this plant in traditional medicine, it prompted us to check B.sensitivum  L. for possible antioxidant activity by DPPH scavenging activity and reducing power ability. The maximum percentage inhibition by DPPH method was found about 43.96 at concentration of 110.46µg/ml, when compared with Quercetin. The reducing capabilities were found to be in dose dependent manner. Key words: Biophytum sensitivum, aluminium chloride, quercetin, DPPH.

Mouth dissolving tablets: a review

Abstract: Conventional dosage forms like tablets and capsules are now days facing the problems like dysphagia, resulting in the high incidence of non compliance and making the therapy ineffective. To obviate the problems associated with conventional dosage forms, mouth dissolving tablets have been developed having good hardness, dose uniformity, easy administration and serves as the first choice of dosage form for paediatrics, geriatrics and travelling patients. The MDTs were developed with an aim of having sufficient hardness, integrity and faster disintegration without water. Fast dissolving Tablets are disintegrating and/or dissolve rapidly in the saliva without the need for water. Some tablets are designed to dissolve in saliva remarkably fast, within a few seconds, and are true fast-dissolving tablets. Others contain agents to enhance the rate of tablet disintegration in the oral cavity, and are more appropriately termed fast-disintegrating tablets, as they may take up to a minute to completely disintegrate. This tablet format is designed to allow administration of an oral solid dose form in the absence of water or fluid intake. Such tablets readily dissolve or disintegrate in the saliva generally within <60 seconds. Keywords: Mouth dissolving tablet, Disintegration, Patented technologies, Marketed MDTs

Review on: recent trend on transdermal drug delivery system

Abstract: Today about 74% of drugs are taken orally and are found not to be as effective as desired. To improve such characters transdermal drug delivery system was emerged. Drug delivery through the skin to achieve a systemic effect of a drug is commonly known as transdermal drug delivery and differs from traditional topical drug delivery. Transdermal drug delivery systems (TDDS) are dosage forms involves drug transport to viable epidermal and or dermal tissues of the skin for local therapeutic effect while a very major fraction of drug is transported into the systemic blood circulation. The adhesive of the transdermal drug delivery system is critical to the safety, efficacy and quality of the product. Topical administration of therapeutic agents offers many advantages over conventional oral and invasive methods of drug delivery. Several important advantages of transdermal drug delivery are limitation of hepatic first pass metabolism, enhancement of therapeutic efficiency and maintenance of steady plasma level of the drug.

A review on the medicinal plant psidium guajava linn. (myrtaceae)

Abstract: Psidium guajava is an important food crop and medicinal plant available in tropical and subtropical countries, widely used in food and folk medicines around the world. It contains important phytoconstituents such as tannins, triterpenes, flavonoid: quercetin, pentacyclic triterpenoid: guajanoic acid, saponins, carotenoids, lectins, leucocyanidin, ellagic acid, amritoside, beta-sitosterol, uvaol, oleanolic acid and ursolic acid. In view of the immense medicinal importance of the plant, this review is an effort to compile all the information reported on its ethanobotanical, phytochemical and pharmacological activities. The present work attempts to generate interest among the masses regarding its potential in preventing and treating several common diseases. Many pharmacological studies have demonstrated the ability of this plant to exhibit antioxidant, hepatoprotective, anti-allergy, antimicrobial, antigenotoxic, antiplasmodial, cytotoxic, antispasmodic, cardioactive, anticough, antidiabetic, antiinflamatory and antinociceptive activities, supporting its traditional uses. Suggesting a wide range of clinical applications for the treatment of infantile rotaviral enteritis, diarrhoea and diabetes. Key words: ethanobotany, myrtaceae, pharmacology, physicochemical, phytochemical, Psidium guajava

Various techniques of bioavailability enhancement: a review

Abstract: Bioavailability is defined as the rate and extent (amount) of absorption of unchanged drug from its dosage form. It is one of the important parameters which are required to achieve optimal concentration of drug in systemic circulation to show a pharmacological response. A drug which has poor bioavailability shows poor aqueous solubility, slow dissolution rate, poor stability of dissolved drug at physiological pH, poor permeation through biological membrane, extensive first pass metabolism. Drugs which are poorly water soluble require high doses to obtain therapeutic plasma concentrations after oral administration of drugs. Low aqueous solubility is the major problem encountered with formulation development of new drugs. Any drug to be absorbed must be present in the form of an aqueous solution at the site of absorption. This review deals with various techniques used for the improvement of the Bioavailability of drugs. The various techniques used are size reduction, solubilising excipients, colloidal drug delivery systems, pH adjustment, solid dispersion, complexation, co‐solvency, micellar solubilisation, hydrotropy etc. The article describes about various techniques which can be utilized to enhance bioavailability of drugs enhancement for their effective absorption in the body