Showing papers in "Journal of Ethnopharmacology in 2020"

TL;DR: This consensus document provides a perspective on what constitutes best practice in pharmacological research on bioactive preparations derived from natural sources, providing a perspective of what the leading specialist journals in the field consider as the core characteristics of good research.

TL;DR: This work comprehensively reviews the state on ethnobotany, ethnopharmacological uses, phytochemicals, combined applications, quality control and toxicology of licorice and will provide systematic insights into this ancient drug for further development and clinical use.

TL;DR: The immunomodulatory effects of AR are closely attributed to its active constituents such as polysaccharides, saponins, and flavonoids and it is demonstrated that AR could be used as a potential therapeutic intervention for immune related diseases through regulating immune organs, mucosal immune, and immune system.

TL;DR: The classical prescriptions of Chinese Medicine, which have been used to prevent and treat Pestilence for long history in China, are systematically excavated to obtain the potential prescriptions and ingredients to alternatively treat COVID-19.

TL;DR: Traditional uses, ethnopharmacology, phytochemistry, pharmacology, toxicity and industrial applications of Gardenia jasminoides Ellis are provided and several suggestions for future application prospects are proposed.

TL;DR: A critical and comprehensive evaluation of the traditional and current medical uses of E. cardamomum and its traditional uses, as well as potential pharmacological properties of CEO and extracts are provided.

TL;DR: GLSO inhibits the growth of MDA-MB-231 cells and tumors in vivo by inducing apoptosis, which may be achieved through the mitochondrial apoptotic pathway.

TL;DR: Despite traditional claims, insufficient scientific validation for the treatment of insomnia, dementia, epilepsy, rheumatoid arthritis, asthma, spleen disorder, puerperal fever and leprosy, necessitate future investigations in this direction.

TL;DR: TGP and its main chemical components are effective in the treatment of autoimmune diseases, such as rheumatoid arthritis, psoriasis, oral lichen planus, and Sjogren's syndrome.

TL;DR: DOP would ameliorate hepatic glucose metabolism via glucagon-mediated signaling pathways and modifying liver-glycogen structure in diabetic mice and provide new knowledge about the antidiabetic mechanism of DOP and further evidence for its clinical use for diabetes.

TL;DR: The EO from C. camphora showed anti-MRSA activity via damaging cell membranes and disturbing the amino metabolism, and had good activity against MRSA, Staphylococcus aureus, Enterococcus faecalis, Bacillus subtilis, Salmonella gallinarum and Escherichia coli.

TL;DR: MLF significantly improved skeletal muscle insulin resistance and mitochondrial function in db/db mice and L6 myocytes through AMPK-PGC-1α signaling pathway, and these findings support the therapeutic effects of MLF on type 2 diabetes.

TL;DR: Results uncovered that loganin inhibits NF-κB signaling and attenuates cartilage matrix catabolism and pyroptosis of chondrocytes in articular cartilage and may serve as a potential therapeutic agent for OA treatment.

TL;DR: According to the principle of syndrome differentiation and treatment, Liver fibrosis patients with different syndromes are treated with different herbal formula, which increases the difficulty of clinical efficacy research, and TCM Herbal formulae have a good prospect in treating liver fibrosis, but its composition of multiple drugs and a wide range of targets intensify the difficulty.

TL;DR: The combination of network pharmacology, metabolomics, western blot, and PCR showed that HLD can treat T2DM by enhancing the gene and protein expression levels of glucose transporter 4, insulin receptor, and mitogen-activated protein kinase 1 to interfere with glyoxylate and dicarboxylate metabolism.

TL;DR: This paper systematically reviewed the pharmacology and toxicology of amygdalin and provided comprehensive information on this compound, suggesting that this compound presented pharmacological activities of anti-tumor, anti-fibrotic,Anti-inflammatory, analgesic, immunomodulatory, anti -atherosclerosis, ameliorating digestive system and reproductive system, improving neurodegeneration and myocardial hypertrophy, as well as reducing blood glucose.

TL;DR: As an important traditional Chinese medicine, modern pharmacological studies have demonstrated that S. alopecuroides has prominent bioactivities, especially on gynecological inflammation and hepatitis B, and anticancer activities, which provide prospects for novel drug development for cancer and some chronic diseases.

TL;DR: CCMF has the clear advantage of providing the exact composition and controllable quality of modern medicines, in addition to having the characteristics of multi-ingredients and multi-targets synergistic effects of TCM, but is still associated with challenges which need to be addressed for its future use.

TL;DR: The theory of dietary herbal medicines, which are an important part of the Traditional Chinese medicine system, has a history of thousands of years, and research on the major compounds with bioactivities, especially those related to its clinical application or healthcare function, need be strengthened.

TL;DR: There is wide spread use of a rich diversity medicinal plants species and practices by TMP to manage OI in HIV/AIDS patients in Uganda, even by patients already on antiretroviral drugs (ARV).

TL;DR: The aim of this study is to quote the summation of the ethnopharmacology, phytochemical profile and pharmacological properties of the resin of Pistacia lentiscus var.

TL;DR: AS-IV significantly attenuated the neurological deficit in rats with ischemica-reperfusion injury, and reduced cerebral infarction and neuronal apoptosis, suggesting that AS-IV might alleviate ischemia reperfusion-induced apoptosis by inhibiting the activation of key factors in death receptor pathway and mitochondrial pathway.

TL;DR: This review aims to critically examine howHypericum species are used ethnomedicinally in China to see if the ethnobotanical data may be useful to help prioritize Hypericum species and certain phytochemical constituents that may be new drug leads, and consider the focus and lack of the phytopharmacological study on Hypericum Species in China.

TL;DR: While both current and former opioid users reported using kratom to ameliorate opioid withdrawal, current users had significantly higher likelihood of using kverbs for that purpose than former users, who were more likely to be using it for its euphoric (mood elevating) effects.

TL;DR: The PEEE HPLC fingerprint may help improve P. emblica quality control, and P.emblica with antioxidant and anti-inflammatory activities may be potentially applied in functional foods or in adjuvant therapy for medicinal development.

TL;DR: This review summarizes the results from current studies of evodiamine, which is one of the valuable medicinal ingredients from Evodia rutaecarpa, and finds that it has significant hepatotoxicity and cardiotoxicity, thereby it should be monitored in clinical.

TL;DR: This study investigated the alterations of PI3K/Akt pathway in polycystic ovary syndrome-insulin resistance (PCOS-IR) progression induced by letrozole combined with high fat diet (HFD) and explored the detailed mechanism of LWDH Pills to alleviate PCOS.

TL;DR: RV hypertrophy and fibrosis were associated with increased expression ofACE, AngII, AT1R as well as decreased expression of ACE2, Ang1-7 and Mas and 35 constituents in Tsantan Sumtang were identified.

TL;DR: This review provides a current data on diversity, phytochemistry, pharmacological activities and traditional uses of K. galanga, an important Indian medicinal herb that has a long history of use in the treatment of several kinds of human ailments.

TL;DR: SXNI can treat IS through multiple targets and routes, and reduce the apoptosis of neuron cells in brain tissue by inhibiting inflammation and regulating the level of oxidative stress, thereby protecting rats brain tissue.