Showing papers in "Journal of Heterocyclic Chemistry in 2007"

TL;DR: In this article, the utility of 2-pyrazoline-5-ones and 2.5-thiones as active Michael donors for the synthesis of spirocyclohexanone derivatives was investigated.

TL;DR: In this paper, the synthesis of various thiophene/phenylene co-oligomers with various terminal groups was reported, and the synthesis is based on either the Suzuki coupling reaction or the Negishi coupling reaction.

TL;DR: Iodine was found to be an efficient catalyst for the synthesis of 2-substituted benzimidazoles by the condensation of orthoesters and 1,2-phenylenediamines in good to excellent yields under mild reaction conditions as discussed by the authors.

TL;DR: Fifteen new pyridazine and phthalazine derivatives were prepared and tested in vitro as antimicrobial compounds and proved to have a remarkable activity against Gram positive germs, the results on Sarciria Luteea being spectacular.

TL;DR: In this article, a short and facile synthesis of pyrido[2,3-d]pyrimidine derivatives was accomplished in good yields via the three-component reaction of aldehydes, alkyl nitriles and aminopyrimidines in water in the presence of triethylbenzylammonium chloride (TEBAC).

TL;DR: In this article, a variety of substituted coumarins have been prepared via an inexpensive and efficient potassium carbonate catalyzed Knoevenagel condensation of salisylaldehydes with acidic methylene compounds in ionic liquid media.

TL;DR: Benzo[4,5]imidazo[1,2-a]pyrimidine derivatives were synthesized via the three-component reaction of aldehyde, β-dicarbonyl compound and 2-aminobenzimidazole in water under microwave irradiation and without catalyst conditions as mentioned in this paper.

TL;DR: In this article, 1-Arylhydrazonopyruvaldehydes 1 react with α,β-unsaturated nitriles 2 to yield 6-amino-1,4-dihydropyridazines 4 that are converted into pyridazinones 5 via refluxing in an acetic acid/hydrochloric acid mixture and into the ethylidenemalononitrile derivatives 6 on reflux with malononiitrile in ethanolic/piperidine solution.

TL;DR: In this paper, 3-substituted acylindoles were obtained via refluxing carboxylic acids with indole in acetic anhydride solutions, which can be readily converted into 4-aminopyrazol-3-ylindole 20 and into 22.

TL;DR: In this article, 2-Acetyl-1-methyl-1H-benzimidazole reacts with dimethylformamide-dimethyl-acetal (DMF-DMA) to afford the corresponding E-1-( 1-methyl, 1H-bensimidaxol 2-yl)-3-N,N-dimethylaminoprop-2-enone.

TL;DR: In this article, pyrazolo[4′,3′:5,6]pyrano[2,3-b]quinoxalin-4(1H)-one and 3-chloroquinoxaline-2-carbonyl chloride using calcium hydroxide in boiling 1,4-dioxane.

TL;DR: In this article, an efficient and fast procedure for the synthesis of 2-(2-pyridyl)azoles was described using ionic liquids as catalysts under microwave irradiation.

TL;DR: A series of pyrazolo[3,4b]pyridines has been synthesized by Friedlander condensation of 5-amino-pyrazole-4-carbaldehyde 1 with active methylene compounds in basic medium as discussed by the authors.

TL;DR: Characterization of the new compounds has been done by means of IR, 1H NMR, MS and elemental analysis, and the antibacterial, antitubercular and antifungal activity of the compounds has also been evaluated.

TL;DR: A series of novel furyl and benzimidazole substituted benzyl ethers were synthesized and evaluated for antibacterial and antifungal activities against S. aureus and MRSA and exhibited the most potent anti-bacterial activity.

TL;DR: In this paper, N-H and N-alkylated derivatives of meridianins have been synthesized as potential antitumor agents by a two-step conversion of N-tosyl-3-acetylindoles or Nalkyl- 3-acetyldolindoles to the corresponding enaminones using DMF-DMA, with or without added pyrrolidine.

TL;DR: In this article, a Suzuki-Miyaura coupling of a 2-pyridylboronic ester with 2-haloazines and -azoles was presented with yields of 47 to 84%.

TL;DR: In this paper, a three-component reaction of alkyl halides, sodium azide and alkynes in water in the presence of CuX (X = Cl, I) afforded 1,4-disubstituted 1,2,3-triazoles in high yields.

TL;DR: A series of 1,3-thiazines has been synthesized by the reactions of N-aroylsubstituted thioureas with ethyl propiolate, dimethyl but-2-ynedioate and (E)-1,4-diphenyl-but 2-ene-1, 4-dione as mentioned in this paper.

TL;DR: An efficient synthesis of four steps to obtain twelve new derivatives of 3,3-dimethyl-2,3,4,5,10,11-hexahydro-8]-(o-; and p-methoxy)phenoxy]-11-[(o,; andp-R)phenyl]-1H-dibenzo[b,e][1,4]diazepin-1-ones IV, 1-12 with possible biological and pharmacological activity as anticonvulsant and schizophrenia treatment in the central nervous system (C

TL;DR: In this article, a linear annulated pentacyclic 6H-diquinothiazine 2H and 6-substituted derivatives were obtained with alkyl, alkyyl, aryl, and heteroaryl substituents in moderate to good yields.

TL;DR: In this article, a series of N-substituted-2-(benzo[d]isoxazol-3-ylmethyl)-1H-benzimidazoles (4) by the condensation of o-phenylenediamine (1) with benzo[D]is oxazol 3-yl-acetic acid (2) and subsequent reactions with different types of electrophiles have been reported.

TL;DR: In this paper, the reaction of 6-amino-2-methylthiouracil and 6 amino-1,3-dimethyluracil with equimolerant amounts of cyclic ketones or cyclic 1-3-diketones and the appropriate aromatic aldehydes yielded regioselectivity a series of polycyclic pyrimido[4,5-b]quinoline and pyrido[2,3d]pyrimidine derivatives in good yields.

TL;DR: In this article, isoselenocyanate with methyl aminoacetate hydrochlorides in the presence of triethylamine afforded selenohydantoins, 2-selenoxoimidazolidin-4-ones, in high yields.

TL;DR: In this paper, 2-oxo-3-(indol-3-yl)propanonitrile 2 condensed with dimethylformamide dimethylacetal to yield the enaminonitriles 3.

TL;DR: In the presence of triethylamine, cycloaddition reaction of enamine 1 with hydrazonoyl halides 2 followed by dimethylamines elimination was achieved, yielding the corresponding 1,3,4-trisubstituted pyrazoles 4.

TL;DR: In this article, a series of functionalized, aryl substituted naphthyridines and quinolines has been synthesized by microwave-assisted one-pot two-component synthesis under solvent-free conditions in good yields by the reaction of a variety of aryls or heteroaryl amines.

TL;DR: In this article, the condensation products of 2-aminoethanol or 3-aminopropanol with substituted benzaldehydes proved to exist in CDCl3 at 300 K as threecomponent tautomeric mixtures of the diastereomeric five- or six-membered 1,3-O,N-heterocyclic ring forms and the corresponding imines.