Showing papers in "Journal of Heterocyclic Chemistry in 2012"

TL;DR: One-pot four-component synthesis of 1,8-dioxo-9-aryl decahydroacridines in solvent-free condition was efficiently performed in the presence of MCM-41-SO3H as a nanocatalyst and nanoreactor in good yields.

TL;DR: The results showed that pyrazoline derivative showed better antibacterial activity on S. typhimurium and E. coli than the reference drug chloramphenicol.

TL;DR: In this article, a synthesis of bis(α-bromo ketones) 5a-c and 6b,c was accomplished by the reaction of bis (acetophenones) 3c and 4c with Nbromosuccinimide in the presence of p-toluenesulfonic acid (p-TsOH).

TL;DR: In this paper, a large series of 1,2-diaryl-benzimidazole and 2-aryl-1H-Benzimidate derivatives were synthesized with slight differences using both microwave irradiation and conventional heating methods.

TL;DR: In this article, the synthesis and applications of 2,2′:6′,2″-terpyridines with thiophene ring, directly linked to the terpyridine core or via a spacer are discussed.

TL;DR: In this paper, a one-pot synthesis of pyrrole derivatives via reaction between activated carbonyl compounds, primary amines, and 1,3-dicarbonyls under solvent-free conditions is described.

TL;DR: A variety of pyrano[2,3-d]pyrimidine-5-one derivatives have been synthesized from 6-amino-4-(substituted phenyl)-5-cyano-3-methyl-1-phenyl-1,4-dihydropyrano [2, 3-c]pyrazole derivatives via cyclization using formic acid and acetic acid as discussed by the authors.

TL;DR: In this article, a mini-library 2,3-dihydroquinazolin-4(1H)-one with good to excellent yields is achieved by tandem reaction of anthranilamides (or anthraninilhydrazides) with aldehydes on grinding at room temperature under solvent-free conditions.

TL;DR: The annulation reaction of vinamidinium salt containing nitrofurazanyl moiety at the β-position gives access to the corresponding pyrazole as discussed by the authors.

TL;DR: In this article, a series of novel 2-aryl-3-(9-alkyl carbazol-3-yl)thiazolidin-4-ones were synthesized by one-pot three-component reactions of 3-amino-9alkylcarbazoles, aromatic aldehydes, and 2-mercaptoacetic acid by using dicyclohexylcarbodiimide (DCC) as a cyclizing agent in dry diethyl ether at room temperature.

TL;DR: The first synthesis of 4,8-dihydro-bis-furazano[3,4-b:3′4′-e] with 2,2-bis(methoxy-NNO-azoxy)ethyl groups has been developed in this paper.

TL;DR: In this article, 4-(1-Imidazolium) butane sulfonate is an excellent catalyst for the synthesis of 2,4,5-trisubstituted and 1,2, 4, 5-tetrasubstitized imidazoles through the condensation of 1, 2-dicarbonyl compounds, aldehydes, and ammonium acetate or amine via multicomponent condensation strategy under solvent-free conditions.

TL;DR: L-Proline is found to be an efficient catalyst for the synthesis of tetrahydrofuro[3,4-b]quinoline-1,8(3H,4H)-dione derivatives as discussed by the authors.

TL;DR: In this article, a review summarizes the literatures dealing with the synthesis of thiosemicarbazone derivatives, chemical reactions and their applications in the synthesisation of important heterocyclic compounds.

TL;DR: In this paper, spiro[indeno[1,2-b]quinoxaline-11,2′-pyrrolidine derivatives were obtained from an efficient multicomponent 1,3-dipolar cycloaddition reaction between ninhydrin, phenylenediamine, sarcosine, and chalcones.

TL;DR: In this article, the nucleophilic substitution of hydrogen in nitro derivative of imidazo[1,2-a]pyridine has been used as a key step in the one-pot synthesis of a new highly fluorescent heterocyclic system pyrido [1″,2″:1′,2′]imidazo [4′,5′:5,6]pryido[2,3-b]indole.

TL;DR: Pyridine and fused pyridines derivatives are interesting compounds with diverse chemical properties and pharmacological activities and the synthesis and antiviral evaluation of some of them are described.

TL;DR: In this article, a modified Friedlander conversion of the cyclocondensation of aromatic o-aminonitriles with carbonyl compounds was discovered, and it was shown that both the new transformation and the classic Friedlander annulation in the presence of ZnCl2 constitute a pair of divergent reaction.

TL;DR: The starting (1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)carbonohydrazonoyl dicyanide (2) was used as key intermediate for the synthesis of 3-amino-2-(1, 5-dimmethyl-3oxo, 2-phenylon-2.5-diaminopyrazole 11 and enaminonitrile derivative 13) respectively as discussed by the authors.

TL;DR: In this paper, a 1,2-Dihydro-2-imino-6-(2-IMino-2H-chromen-3-yl)-1,4-diphenyl-pyridine-3 carbonitrile 4 has been synthesized and reacted with ethyl cyanoacetate to yield the new 5-amino-1,7-dihydron-2-(2.

TL;DR: A series of 4-aryl-3,7,7-trimethyl-1-phenyl-7,8-dihydro-1H-pyrazolo[3,4-b]quinolin-5(6H)-ones were synthesized by the three-component reaction of aromatic aldehydes, 3-methyl-1phenyl 1H-polycyclic pyrazol-5-amine, and 5,5-dimethyl 1,3-cyclohexandione in the presence of sodium 1-dodec

TL;DR: In this article, an efficient and convenient synthesis of substituted 4H-chromenes was described using room temperature ionic liquid (RTIL) choline chloride-urea in one pot under solvent free conditions.

TL;DR: In this article, the synthesis and biological properties of some novel isolated or fused heterocyclic ring systems with pyrazole were described, including enaminones containing pyrazolone ring photochromic functional unit, 4-[(4-chlorophenylamino)methylene]-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one (3) and some analogous derivatives 4, 9, and 10, also as pyrazolo[3, 4-b]pyridine, pyrazoline, py

TL;DR: In this article, a series of new 5-(1-aryl-1H-pyrazole-4-yl)-1Htetrazoles 4a-l were synthesized via [3 + 2] cycloaddition reaction from 1-aryl, 1H, pyrazole, 4-carbonitriles, sodium azide and ammonium chloride, using dimethylformamide (DMF) as solvent, in good yields: 64-85%.

TL;DR: A series of novel 1,5-diaryl-1H-pyrazol-3-oxy derivatives containing oxyacetic acid or oxy(2-thioxothiazolidin-3yl)ethanone moieties were prepared from methyl 3-arylacrylates via a serial of reactions included addition-cyclization, oxidation, substitution, hydrolysis, and condensation as mentioned in this paper.

TL;DR: In this article, a cyclo-condensation reaction of indolin-2-ones, barbituric acids, and 1,3-diphenyl-1H-pyrazol-5-amines with the ionic liquid as an effective green reaction media and in the presence of Alum as a reusable catalyst was reported.

TL;DR: None of the tested compounds showed inhibitory activity against gram positive bacteria Enterococcus faecalis and Bacillus cereus and against gram negative bacteria Pseudomonas aeruginosa.

TL;DR: In this article, the synthesis and characterization of thieno[3,4-b]pyrazines and its extended fused-ring analogs are described as important building blocks for the production of low-band gap conjugated materials.

TL;DR: One derivative of 1,3-thiazolidine showed moderate antiproliferative in vitro activity against hepatocellular carcinoma Hep-G2, whereas another one introduced effective antioxidant activity compared to ascorbic acid.