Showing papers in "Journal of Heterocyclic Chemistry in 2013"

TL;DR: In this paper, 3-phenyl-5-aryl-1-thiocarbamoyl-2-pyrazolines with 2-bromopropionic acid, maleic anhydride, N-arylmaleimides, and aroylacrylic acids have been synthesized.

TL;DR: 3,4, 5-Trinitro-1H-pyrazole has been obtained via nitration of 3,5-dinitropyrazole with mixture of sulfuric and nitric acids with high yields but nucleophilic substitutions in these cases occur regioselectively at position 5 in 4 to afford 5-R-3, 4-d Initropyrazoles.

TL;DR: The use of palladium complexes in catalyzing the cross-coupling of halogenated quinolines with various organometalic reagents has led to the development of radically new methods of synthesizing novel substituted quinoline derivatives as discussed by the authors.

TL;DR: In this paper, a simple, convenient, and multicomponent strategy for synthesis of spirooxindole derivatives has been developed, which provides a rapid access to construct a diversity-oriented library of spoxide derivatives by using three simple and readily available isatin, malononitrile or cyanoacetic ester, and 1,3-dicarbonyl compound catalyzed by hexamethylenetetetramine in water.

TL;DR: In this paper, the formation of piperidine derivatives was assumed to proceed via reaction of the aldehyde with a β-ketoester-derived enolate anion to form an α-substituted β-ketoester intermediate.

TL;DR: In this article, α-alkoxy- and α-hydroxyphosphonate derivatives of tetrazole-quinolines were synthesized from the reaction of 2-azidoquinoline 3-carboxaldehyde 1a,b with trialkyl phosphites and dialkyl phosphites.

TL;DR: Most of the synthesized compounds showed potent antimicrobial activity against gram positive and gram negative bacteria as well as fungi species.

TL;DR: In this article substituted pyrazole, thiazole, and 1,2,4-triazole derivatives were synthesized, and the antitumor activity of some of the synthesized compounds were studied.

TL;DR: In this paper, the synthesis of 1,2,4-triazoles, 1,3,4oxadiazoles and 1, 3, 4-thiadiazole bearing a 5-(1-(4-(5-chloro-3-fluoropyridin-2-yloxy)phenoxy)ethyl) unit, as a moiety of commercial herbicide, using their thiosemicarbazides in an alkaline, iodine and acidic media is reported, respectively.

TL;DR: In this article, the synthesis and anticonvulsant evaluation of 1-ethyl-3-hydrazinylquinoxaline-2-(1H)-one (8), its chemical confirmations 9 and 10 and certain (1,2,4) triazolo(4,3-a)quinoxalin-4(5H) one compounds 11, 12, 13, 13a, 13b, 13c, 13d, 13e, 13f, 14, 15, 16.

TL;DR: In this article, an efficient synthesis of novel 2-aryl-3-(phenylamino)-2,3-dihydroquinazolin-4(1H)-one derivatives using KAl(SO4)2.12H2O (Alum) as a catalyst from an aldehyde and 2-amino-N-phenylbenzohydrazine in ethanol is described.

TL;DR: In this article, a modified synthetic method for the synthesis of 2-chloro-4,6-dimethyl-nicotinonitrile (3) through the reaction of acetylacetone and malononitriles as starting materials was implemented.

TL;DR: Several novel benzoxaborole derivatives were synthesized starting from 2-formylphenylboronic acid utilizing Baylis–Hillman reaction, Barbier allylation, Passerini reaction, and aldol reaction protocols as the key step.

TL;DR: In this paper, a one-pot, four-component reaction for the efficient synthesis of novel spiro[indeno[2,1b]quinoxaline-11,4′-pyran]-2′-amines by using InCl3 is described.

TL;DR: In this article, some new 4,6-dimethoxy pyrimidine derivatives were synthesized and the structures of these compounds were established on the basis of IR, 1H NMR, APT and HRMS spectral data and were evaluated for antibacterial activities against various bacterial strains.

TL;DR: In this paper, the authors have reported the isolation, structure determination and cytotoxicity of three new 5-hydroxyindole alkaloids, i.e., 5-HOI, 5HOI and 5-HI.

TL;DR: In this paper, a method for the synthesis of carbazoles from 1-keto-1,2,3,4-tetrahydrocarbazoles via the corresponding tosylsulfonhydrazones by a one-pot tandem reduction-oxidation protocol using a combination of NaBH4 and Pd-C on MgSO4·7H2O, a solid support, under microwave is developed.

TL;DR: In this paper, an efficient one-pot synthetic protocol for polyfunctionalized 1,4-dihydropyridine-fused-1,3-diazaheterocycles, a class of biologically active compounds, starting from 1,1-bis(methylthio)-2-nitroethylene, 1,n-diamine, arylaldehyde, and malononitrile is described.

TL;DR: Some new triazolo[1,5a]pyridines incorporating 6-methylchromone moiety were prepared from the reaction of 1,6-diamino-4-(6-methyl-4-oxo-4H-chromen-3-yl)-2-oxoxo, 1,2-dihydropyridine-3,5-dicarbonitrile (4) with some electrophilic reagents as discussed by the authors.

TL;DR: In this article, a β-enaminonitrile of 1-(6-phenyl-pyridazin-3-yl)-pyrazole derivative 2 was formed using 2-ethoxymethylene-malon-itrile.

TL;DR: In this article, the first furoxan and 1,3,4-oxadiazole ring ensembles were synthesized from accessible azides and hydrazides of Furoxancarboxylic acids.

TL;DR: In this paper, a review summarizes recent literatures dealing with the synthetic tools of thieno[2,3-d]pyrimidine derivatives including their biological activities and their applications in the synthesis of heterocycles.

TL;DR: In this article, the reaction of 4-oxo-3,4-dihydroquinazolinyl-2-guanidine 1 with several active methylene compounds has revealed formation of the corresponding hydropyrimidine and dihydropyrimidnone (DHPMs) derivatives via cycloaddition reaction mechanism.

TL;DR: In this article, 2-amino-1,3,4,4-thiadiazole (1) with α,β-unsaturated carbonyl compounds 2, 5, and 9 were shown to be antitumor agents.

TL;DR: Solubility of the salts in simulated gastric fluid (SGF) and other pharmaceutically used solvents such as ethanol and propylene glycol was improved to a great extent and it was observed that from 1a, 1b, and 1c, approximately 33, 26, and 45% drug was released in SGF in 3 h, whereas less than 10%Drug was released from the free base form.

TL;DR: In this article, the synthesis of 2,4,5-trisubstituted imidazoles in high yields from 1,2-diketones and aldehydes in the presence of NH4OAc via multi-components reaction is described.

TL;DR: A green and highly efficient method for the synthesis of polyfunctionalized indoline-spiro fused pyran derivatives has been established in this article, which shows fascinating properties such as the use of water as the reaction solution, concise one-pot conditions, short reaction periods (8-14 min), and easy purifications.

TL;DR: In this article, 1,2,4-triazine and derived thioglycoside derivatives were synthesized from 5,6-diphenyl-1, 2, 4, 4 triazine-3-thiol.