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Showing papers in "Journal of Heterocyclic Chemistry in 2015"


Journal ArticleDOI
TL;DR: In this article, the anti-cancer activity of 1,3,4-oxadiazolyl-phenylthiourea 3 with hydrazonoyl halides was evaluated for the colon carcinoma cell line (HCT-116).

66 citations


Journal ArticleDOI
TL;DR: An overview of the application of microwave irradiation in the synthesis of two nitrogen atoms containing five-membered heterocyclic compounds is presented, focusing on the developments in the last 5-10 years as discussed by the authors.

53 citations


Journal ArticleDOI
TL;DR: In this article, a simple and straight forward solvent free method for the synthesis of a series of highly functionalized tetrahydropyridine derivatives has been achieved via multicomponent reaction of aromatic aldehydes, various amines, and β-keto esters at room temperature using readily available (±)-camphor-10-sulfonic acid as an organocatalyst.

35 citations


Journal ArticleDOI
TL;DR: In this paper, a simple, straightforward and highly efficient multicomponent one-pot synthesis of a series of pharmaceutically interesting benzopyranopyrimidine and 4H-chromene derivatives has been developed on the basis of low-cost and environment-friendly sodium formate catalyst via tandem reactions of salicylic aldehydes, malononitrile, and cyclic secondary amines in ethanol at room temperature.

33 citations


Journal ArticleDOI
TL;DR: A series of highly stereoselective polysubstituted cyclopropane derivatives were synthesized via one-pot two-step tandem reaction starting from pyridine, 4-chloro phenacyl bromide, 1,3-indandione and aromatic aldehydes in acetonitrile using triethylamine as catalyst.

30 citations


Journal ArticleDOI
TL;DR: The synthesis and chemical behavior of 3-functionalized 5,6-diphenyl-1,2,4-triazines towards some electrophilic and nucleophilic reagents are reviewed in this paper.

27 citations


Journal ArticleDOI
TL;DR: In this paper, the use of NbCl5 as a Lewis acid in multicomponent reactions between benzaldehyde, aniline derivatives and phenylacetylene in the synthesis of quinoline derivatives was investigated.

25 citations


Journal ArticleDOI
TL;DR: In this paper, a bromine-assisted direct electrophilic heterocyclization of 3-N-allylamine-5,6-dihydro[1,3]thiazolo[2,3-c][1,2,4]triazole is presented.

24 citations


Journal ArticleDOI
TL;DR: In this article, a series of 4-(4-substitutedbenzylideneamino)-5-((1-methyl-1H-tetrazol-5-ylthio)methyl)-4H-1,2,4-triazole-3-thiol derivatives (5a, 5b, 5c, 5d, 5e, 5f, 5g, 5h, 5i, 5j, 5k) are prepared using 4-amino as an intermediate compound.

23 citations


Journal ArticleDOI
TL;DR: In this paper, a facile and efficient synthesis of polyhydroquinolines has been developed via four-component condensation reactions of aldehydes, dimedone, ethyl acetoacetate, and ammonium acetate in the presence of Novel SO3H-functionalized ionic liquid catalysts through Hantzsch reaction under ultrasound irradiation without solvent.

23 citations


Journal ArticleDOI
TL;DR: In this paper, a wide variety of spiroquinazolinone derivatives have been synthesized via a one-pot three-component reaction of isatoic anhydride, cyclic ketones, and hydrazides in the presence of catalytic amount (20m) of H3PO3 in ethanol.

Journal ArticleDOI
TL;DR: A series of novel 5-arylazo-thiazol-2-ylcarbamoyl-thiophene derivatives was synthesized, and their chemical structures were secured by elemental and spectroscopic analyses as discussed by the authors.

Journal ArticleDOI
TL;DR: An atom economic and facile synthesis of novel dispiro–oxindole–pyrrolidines has been achieved via a three-component tandem cycloaddition of azomethine ylide generated in situ from isatin and sarcosine by decarboxylative condensation with N-aryl-3-benzylidene- pyrrolidine-2,5-dione derivatives as dipolarophiles.

Journal ArticleDOI
TL;DR: The antimicrobial activity of five of the synthesized compounds was examined against one gram positive bacteria, one gram negative bacteria, and two fungi.

Journal ArticleDOI
TL;DR: In this article, a series of novel (1H-benzo[d]imidazole-2-yl)-6-(diethylamino)-3H-one-xanthene, phenoxazine, and oxazine derivatives have been synthesized from 2-(2′,4′-dihydroxyphenyl) benzimidrazole intermediate.

Journal ArticleDOI
TL;DR: Starting from 3-acetyl-2H-chromen-2-one and hydrazinecarbothiohydrazide, new functionalized thiazoles, 1,3,4-thiadiazines, and 1, 3, 4thiadiadiazoles were prepared.

Journal ArticleDOI
TL;DR: The reaction of the stabilized phosphonium ylides 2a, 2b with indolinones 1a, 1b and naphthofuranone 13 afforded the corresponding propylidene derivatives 4a, 4b, 4c, 4d and 14a, 14b.

Journal ArticleDOI
TL;DR: In this article, a new and environmentally benign multi-component synthesis of tetra substituted 4H-pyran derivatives is developed via the one-pot reaction of an aromatic aldehyde, malononitrile, and 1,3-diketone in the presence of NaOH with water as the solvent at RT.

Journal ArticleDOI
TL;DR: 2-Amino-4H-chromenes were synthesized in moderate to good yields by the reaction of o-quinone methides photochemically generated from o-(dimethylaminomethyl)phenols with malononitrile and could be used for the reaction in the presence of tertiary amine bases.

Journal ArticleDOI
TL;DR: In this article, a mechanism for the formation of hydrazine is proposed, and the position of the aryl substituents on the bicyclic ring has been established by the combined use of NMR and DFT calculations.

Journal ArticleDOI
TL;DR: In this paper, the chemical reactivity of 6,8-dibromo-7-hydroxychromone-3-carboxaldehyde was studied towards some nitrogen nucleophilic reagents such as heterocyclic amines under different reaction conditions.

Journal ArticleDOI
TL;DR: In this article, the synthesis of novel pyrrolidine derivatives was described and subjected to intramolecular cycloaddition with azomethine ylides derived in situ from the reaction with sarcosine, phenylglycine, and L-proline.

Journal ArticleDOI
TL;DR: In this article, a regioselective synthesis of novel pyrazolo[3,4d]pyrimidines, imidazo[1,2-b]pyrazoles, pyrazolines incorporating a thiazole moiety was described via the reactions of the versatile, readily accessible 5-amino-3-(phenylamino)-N-(4-phenylthiazol-2-yl)-1H-pyrazole-4-carboxamide (1) with each of DMF-DMA, phenyl

Journal ArticleDOI
TL;DR: A series of 4-arylmethylidene-3-substituted-isoxazol-5(4H)-ones were efficiently synthesized by eco-benign, one pot uncatalyzed reaction of β-keto-ester, hydroxylamine hydrochloride, and aromatic aldehyde with electron donating substituent in water as discussed by the authors.

Journal ArticleDOI
TL;DR: In this paper, a series of trifluoromethylated aurone derivatives were synthesized, and the structure of 6-hydroxy-4-trifluoric acid-based aurone was determined by single crystal X-ray analysis.

Journal ArticleDOI
TL;DR: An efficient synthesis of 2-amino-4a,5,6,7-tetrahydronaphthalene-1,3,3(4H)-tricarbonitriles via the tandem four-component condensation of one equivalent of aromatic aldehyde, cyclohexanone, and two equivalents of malononitrile in ionic liquids was undertaken in this paper.

Journal ArticleDOI
TL;DR: In this article, some new heterocyclic compounds incorporating quinolone moieties were achieved via reaction of 4-hydroxy-7-methoxyquinolin-2(1H)-one (1) or 3-bromo-4-hydrox-7methoxinol 2 (1H-one) with binucleophilic reagents, which were characterized by elemental analyses and spectral data (IR, 1H-NMR and mass spectra).

Journal ArticleDOI
TL;DR: An efficient green protocol for the synthesis of quinazolines in the absence of solvent and catalyst has been developed in this paper, which has advantages of operational simplicity, substrate generality, clean reaction, high yields (76-94%), and moderate reaction time.

Journal ArticleDOI
TL;DR: Structural-activity relationship studies with respect to the nature and position of substituents on the lead compounds could be further exploited for the design and development of more potent antiproliferative agents and/or Src kinase inhibitors.

Journal ArticleDOI
TL;DR: A series of complex oxazatricyclic systems was efficiently synthesized in satisfactory yields by three-component reaction of isoquinolinium salts, acetone, and cyclic 1,3-dicarbonyl compounds in ethanol in the presence of triethylamine as base catalyst as mentioned in this paper.