Showing papers in "Journal of Heterocyclic Chemistry in 2017"

TL;DR: A broad view on biological activities of compounds having thiazole nucleus is highlighted and similar compounds synthesized through different routes bear variable magnitudes of biological activities.

TL;DR: A library of 1-2,3-triazoles efficiently prepared via click chemistry and evaluated for their antifungal, antitubercular, antioxidant, cytotoxicity, molecular docking and ADME prediction.

TL;DR: An efficient and convenient method for the synthesis of bis(4H-chromene-3 carbonitrile) derivatives by one-pot, multicomponent reaction of bis-aldehydes, malononitrile, and dimedone in the presence of a catalytic amount of piperidine is reported in this paper.

TL;DR: In this paper, a simple, efficient, and eco-friendly procedure was developed for the synthesis of bis(4H-chromene-3-carbonitrile) derivatives using chitosan as catalyst under microwave-assisted reaction conditions.

TL;DR: A new class of 1H-1,2,3-triazole-tethered 8- OMe ciprofloxacin (8-OMe CPFX) isatin hybrids 5a–l was designed, synthesized and screened for their in vitro anti-mycobacterial activities against Mycobacterium tuberculosis H37Rv and multi-drug-resistant tuberculosis (MDR-TB).

TL;DR: In this article, a simple three-components reaction between alkynes, primary amines, and isothiocyanates in the presence of nanophase ZnO catalysts in aqueous medium at room temperature was reported which produced 1,3-thiazolidine derivatives in good yields.

TL;DR: In this article, a multi-component synthesis of pyranopyrazole derivatives by using montmorillonite K-10 as a reusable green acid catalyst under ecofriendly method in the presence of eco-friendly solvent leads to novel protocol.

TL;DR: In this article, a clean and efficient methodologies involving one-pot three-component synthesis of bis-aldehydes, malonitrile dimer, and dimedone in the presence of piperidine as a catalyst in EtOH was presented.

TL;DR: An overview of the significance of the pyridazine scaffold in crop protection chemistry is given in this paper, together with their synthesis routes, modes of action, and biological efficacies.

TL;DR: In this article, the authors developed green and efficient regioselective and chem-lective syntheses of 5-aryloyl-1,3-dimethyl-7-thioxo-5,6,7,8-tetrahydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione and 5-yronyl- 1,3dimethyl -2,7-dithioxo,2,3,5, 6, 7, 8-hex

TL;DR: In this article, the synthesis of benzo[d]imidazoles through condensation of 1,2-diaminobenzene with aryl aldehydes is described.

TL;DR: A series of pyrazole carboxamide derivatives had been designed, synthesized and some of them exhibited good nematocidal activity as mentioned in this paper, but they were not suitable for use in the field of bioengineering.

TL;DR: In this paper, a synthesis of bis(dihydropyridine-3,5-dicarbonitrile) by a three-component reaction of one equivalent of bis-cyanoacetamides with two equivalents of both arylaldehydes and malonitrile in ethanol-containing piperidine is reported.

TL;DR: In this paper, the basic principles of microwave technology and its use in the synthesis of pyrrole derivatives are outlined and discussed in the context of azaheterocyclic systems.

TL;DR: In this paper, a new series of azolopyrimidine derivatives incorporating pyrazole moiety were synthesized by reaction of 1-(pyrazol-3-yl)-2-propenone with a number of heterocyclic amines in the presence of a catalytic amount of acetic acid.

TL;DR: An overview of the structure, functionalities, and use of triazoles with a focus on their use in catalytic systems is given in this article, where the triazole motif has been used in various functional materials, such as metallic and anionic sensors.

TL;DR: In this article, the regioselective spiroindoline derivatives were afforded via multi-componant reaction, and the antibacterial and antioxidant activities for these synthesized compounds could be investigated.

TL;DR: In this article, the authors used 3-methyl-4-phenylthiocarbamoyl-1-thiamoyl -2-pyrazolin-5-one as a core compound for the synthesis of 1-(thiazol-2-yl)-pyrazolone derivatives through diazo-coupling reaction and/or Knoevenagel condensation.

TL;DR: A review of the recent development in the multi-component synthesis of pyridopyrimidine and spiro-conjugated pyridephyrimidine systems can be found in this article.

TL;DR: In this paper, a novel thieno[2,3,b]quinoline-2-carboxylic acid derivatives including β-diketone, pyrazole, and flavone were prepared under ultrasonication and evaluated for in vitro antioxidant and anti-inflammatory activities.

TL;DR: In this paper, a mild, efficient, and environmentally green protocol for the synthesis of 2-tosyloxyphenylpyran derivatives via reaction of two-to-benzaldehyde with malonitrile and some ketonic reagents in one-pot, three component reaction was proposed.

TL;DR: Docking of some of the synthesized compounds into the active sites of lipase, α-glucosidase, and urease was carried out in order to predict the binding affinities and noncovalent interactions stabilizing the enzyme–ligand complexes.

TL;DR: In this article, the conversion of the 2(3H)-furanone into the oxazinone and pyrimidinone derivatives was studied, and a 2-(furan-2-ylmethylene)-4-oxo-4-phenylbutanoyl azide 3 was synthesized to carry out these conversions through its thermolysis in dry benzene and/or base-catalyzed decomposition of this azide in the presence of different amines.