Showing papers in "Journal of Heterocyclic Chemistry in 2018"

TL;DR: This review aims to outline the biological activities of coumarin–triazole hybrids, and discuss their structure–activity relationship to pave the way for the further rational development of this kind of hybrids.

TL;DR: Mostafa et al. as mentioned in this paper proposed a method to solve the JET problem by using the most recent version of the Jhet algorithm. But their method is not suitable for the problem of high dimensional data.

TL;DR: A new class of propylene-1H-1,2,3-triazole-4-methylene-tethered (thio)semicarbazone-isatin-moxifloxacin hybrids 6a–h was designed, synthesized, and screened for their in vitro anti-mycobacterial activities against Mycobacterium tuberculosis H37Rv and MDR-TB as well as cytotoxicity in VERO cell line

TL;DR: A series of quinoline derivatives containing perfluoropropanyl moiety were designed and synthesized in this article, and the bioassay results showed that some of them exhibited good control efficacy against Pyricularia oryae.

TL;DR: A new series from thieno[2,3-d] pyrimidine derivatives have been synthesized based on 2(ethylmer Capto)-4-mercapto-6-phenyl-5-pyrimidine carbonitrile, these compounds used in the synthesis of many pyrimidothienopyrimidine derivative and triazolo.

TL;DR: In this article, an easy and effective procedure for one-pot three components coupling of 4-hydroxycumarin, isothiocyanates, and isocyanides in water by employing magnetically recoverable Fe3O4 nanoparticles is described.

TL;DR: A new set of ciprofloxacin-isatin-1H-1,2,3-triazole hybrids 6a–l with greater lipophilicity compared with the parent CPFX was designed, synthesized, and assessed for their in vitro anti-mycobacterial activity against Mycobacterium tuberculosis (MTB) H37Rv as well as cytotoxicity in VERO cell line.

TL;DR: Biological evaluation showed that these synthesized spiro-pyrrolidine exhibited moderate to good cytotoxic activity and compounds 4, 5, and 12 exhibited strong cytotoxicity s against MCF-7 mammary gland cell line.

TL;DR: The World Academy of Sciences (TWAS) was gratefully acknowledged by OOA for the sponsorship of this present work under the TWAS Research Grant for Individual Scientists in Basic Sciences Programme (grant no. 14-069 RG/CHE/AF/AC_1) as discussed by the authors.