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Showing papers in "Journal of Inorganic Biochemistry in 1988"


Journal ArticleDOI
TL;DR: A mechanism for ferritin iron reduction and release by o-diphenols consistent with the experimental observations is discussed, and a direct correlation between reducing power of the o-caffeic acid, chlorogenic acid, and several analogs and rate of ferritIn iron release was observed.

120 citations


Journal ArticleDOI
TL;DR: Tetrahedral, bischelated Ag(I) diphosphine complexes [Ag(P-P)2]NO3, where P-P is Ph2P(CH2)2PPh2 (dppey), are potently cytotoxic to B16 melanoma cells in vitro and exhibit good activity against ip P388 leukemia in mice.

103 citations


Journal ArticleDOI
TL;DR: Over the concentration range considered, gold(III)tetrakis(4-N-methylpyridyl) porphyrin does not aggregate, binds axial ligands only weakly with a preference for soft Lewis bases, and is capable of intercalation into nucleic acids of appropriate base pair content.

84 citations


Journal ArticleDOI
TL;DR: All the ligands and metal complexes were screened for their antitumor activity against P 388 lymphocytic leukemia test system in mice, and it was found that a few of them possess significant activity at the dosages used.

69 citations


Journal ArticleDOI
TL;DR: It was demonstrated in these studies that the fraction of antibiotic not bound to proteins almost exclusively occurs as calcium and magnesium complexes, and it was postulated that the partial blocking of one of the potential coordination sites of the TC molecule, which would favor the formation of neutral mononuclear complexes, should result in a better tissue penetration of the drug.

68 citations


Journal ArticleDOI
TL;DR: In this article, the adsorption of either chromium(III) or chromate(VI) by plants has been investigated by means of ESR spectroscopy, and the intensity ratio between the ESR signals of Cr(V) and Cr(III)-species became almost constant with elapsing contact time, but decreased as the chromium concentration in solution was lowered.

63 citations


Journal ArticleDOI
TL;DR: The results indicate that the form of Se administered will influence the form in the tissues, the percentage of Se with GPx and the body burden of Se.

59 citations


Journal ArticleDOI
TL;DR: The results reveal the important role of magnesium on the calcification of human valves, and the apatitic phase deposited at the beginning of the calcifying process, when there is a high magnesium content, converts completely into beta-tricalcium phosphate by heat treatment at 1,000 degrees C.

52 citations


Journal ArticleDOI
TL;DR: The magnetic properties of intact and freeze-dried blood cells of the tunicate Ascidia nigra and of model vanadium(III) and (IV) compounds as polycrystalline solids and in aqueous solution have been measured with a SQUID susceptometer and consistent results with vanadium (III) the predominant species are given.

50 citations


Journal ArticleDOI
TL;DR: In the context of a study of the molecular basis of the antileukemia (murine) activity of diorganotin (IV) compounds, the interaction with rat hemoglobin of the representative terms dimethyltin dichloride, dimethyeltin glycylglycinate (Me2SnGlyGly), and dimethygtin L-cysteinate has been investigated by 119Sn Mössbauer spectroscopy.

49 citations


Journal ArticleDOI
TL;DR: In this paper, the enthalpies of complex formation of these metal cations with phytic acid are compared to those of two other metalcations, Mn(II and Cu(II), which were studied under similar conditions.

Journal ArticleDOI
TL;DR: Nature of the EPR spectra and magnetic moment values point to the monomeric character of the complexes and suggest a distorted octahedral donor environment for the oxovanadium(IV) ion.

Journal ArticleDOI
TL;DR: A structural model of Pt7MT is proposed in which the square planar tetrathiolate Pt(II) unit is incorporated into a three-metal beta cluster and implications for the metabolism of platinum anticancer drugs are discussed.

Journal ArticleDOI
TL;DR: Reactions of cis- and trans-dichlorodiammineplatinum(II) with proteins appear to be more selective than those observed for modification with the trans isomer.

Journal ArticleDOI
TL;DR: A potentiometric and spectroscopic study of the H+, Cu2+, and Ni2+ complexes of luteinizing hormone-releasing hormone at 25 degrees C and an ionic strength 0.10 mol dm-3 (KNO3), since there is much evidence that the in vivo release of LHRH is influenced by the concentration of copper ions.

Journal ArticleDOI
TL;DR: Electron paramagnetic resonance (e.p.r.) studies of thin DNA-chelate films indicate that both the water soluble planar macrocyclic chelates, cobalt (II) tetra (2,3-N-methylpyridinium) porphyrazine (cobalt ( II) TMTPPA), and vanadyl (II)'s porphyrin can bind to calf thymus DNA intercalatively.

Journal ArticleDOI
I.M.A. Awad1, Aref A. M. Aly1, A.M. Abdel-Alim1, R.A. Abdel-Aal, S.H. Ahmed1 
TL;DR: Antidotal activity of four ligands has been evaluated in mice against the toxicity of lead acetate and copper sulphate and revealed that compound IIIf elicited significant antidotal activity against lead and copper poisoning, while IIIi was potent only against lead poisoning.

Journal ArticleDOI
TL;DR: This reaction was markedly slower, at least as judged by the thermal decay curves, and had an enthalpy considerably larger in magnitude than those of all of the divalent cation-phytate reactions thus far investigated in this manner.

Journal ArticleDOI
TL;DR: In this article, the authors investigated the interaction of Mg 2+, Pb 2+ and Sr 2+ with OCP, DCPD, and HAP under conditions of cyclic pH fluctuation.

Journal ArticleDOI
TL;DR: It was concluded that the substituted benzimidazole derivatives behave as bidentate ligands, being bound to the metal atoms via the nitrogen of the -N = group and the amino group of the side chain of the benzimdazole ring.

Journal ArticleDOI
TL;DR: The experimental results seem to suggest that the major contribution in DNA stabilization by means of tetramines is due to the electrostatic interactions occurring between the protonated nitrogen atoms of the amine molecules and the phosphate groups of nucleotides in the nucleic chains.

Journal ArticleDOI
TL;DR: The results strongly support the previous proposal that binding of the synergistic bicarbonate anion is responsible for the uv absorption observed upon addition of bICarbonate to apoTf.

Journal ArticleDOI
TL;DR: It is shown that the monomeric MP-8 activates oxygen in a similar manner to that already reported for alkaline hemin, establishing the octapeptide as a possible second generation model for the oxygen activation/insertion reactions of the cytochrome P-450.

Journal ArticleDOI
TL;DR: A considerable increase in the biocidal activity of these ligands on being coordinated with the metal ions was reported in terms of their minimum inhibitory concentration (MIC) values.

Journal ArticleDOI
TL;DR: Resonance Raman spectra of native bovine liver ferri-catalase are relatively insensitive to pH over the range of 5-10, and the same spectra are observed for catalase samples that do and do not contain tightly bound NADPH.

Journal ArticleDOI
TL;DR: Results indicate a faster but less complete uptake of oxygen in cells from patients with rheumatoid arthritis than is the case in normal cell populations.

Journal ArticleDOI
TL;DR: The proton NMR spectrum of glycine was monitored in D2O solution as a function of added Hg(II) concentration and pD and formation constants were used to calculate speciation over a range of ligand concentrations.

Journal ArticleDOI
TL;DR: In conjunction with electronic absorption studies on these complexes it can be concluded that N3-, but not the amino acid carboxylate, is bound to the metal.

Journal ArticleDOI
TL;DR: EPR measurements as a function of temperature demonstrate that the relaxation behavior of the S = 3/2 MoFe centers associated with the proteins differ markedly, and the different EPRbehavior of the two proteins seems to arise either from protein constraints imposed on identical cofactors, and/or from magnetic interactions due to neighboring metal clusters.

Journal ArticleDOI
TL;DR: It is concluded that low molecular weight water soluble cobalt(III) porphyrins might be used as effectively and at lower dose levels than hydroxocobalamin (B12b), a known in vivo anticyanide agent.