Showing papers in "Journal of Inorganic Biochemistry in 2003"

TL;DR: The sequence and structural selectivity of 15 different DNA binding agents was explored using a novel, thermodynamically rigorous, competition dialysis procedure, and selective agents showed in many cases less dramatic binding selectivity than anticipated from published reports that compared their binding to only a few structural forms.

TL;DR: Twelve zinc(II) complexes with thiosemicarbazone and semicarbazones ligands were prepared and characterized by elemental analysis, thermogravimetric and differential thermal analysis (TG/DTA), FT-IR and 1H and 13C NMR spectroscopy, and showed antimicrobial activities against bacteria, yeasts and molds.

TL;DR: The representative Schiff bases and their complexes were tested in vitro to evaluate their activity against fungi, namely, Aspergillus flavus (A. flavus) and Fusarium species.

TL;DR: Experimental results indicated that La(III) complex and chrysin can both bind to DNA by intercalation modes, but the binding affinity of La( III) complex is much higher than that of chrysIn, which shows that at the concentration of 10 microM for chrys in and La(II) complex, the inhibitory ratios against the tested tumor cells were higher than those of Chrysin.

TL;DR: The potentiometric and spectroscopic data show that acetylation of the amino terminal group induces significant changes in the coordination properties of the (Ac-1-16H) and (1-2-16M) peptides compared to the (1

TL;DR: Absorption titration and thermal denaturation experiments indicate that the Co(bzimpy)(2) complex binds to DNA with moderate strength, and viscosity measurement shows that the mode of binding could be surface binding.

TL;DR: In this review, the recent progress made in the research of external detoxification of Al is described and a gene encoding the malate channel has been cloned.

TL;DR: Evidence is provided that hZIP1 is an important operational transporter that allows for the transport and accumulation of zinc in the zinc-accumulating human prostate cell lines, LNCaP and PC-3.

TL;DR: The thiosemicarbazone derivative of 9,10-phenanthrenequinone, 1, and its metal complexes were synthesized and the X-ray crystal structure confirms the presence of the E tautomeric arrangement in this compound.

TL;DR: A fully fledged biogeochemical cycle for aluminium should explain the biospheric abundance of this element and whether the authors should expect its (continued) active involvement in biochemical evolution.

TL;DR: A sequence of events accounting for cadmium-induced mitochondrial impairment is proposed, beginning with an apparent interaction of Cd( 2+) with specific protein thiols in the mitochondrial membrane, which stimulates the cation's uptake via the Ca(2+) uniporter, and is followed by the onset of mitochondrial permeability transition (MPT).

TL;DR: While both the investigated cobalt(III) complexes and also [Ni(phen)(2)(qdppz)](2+) affected the photocleavage of DNA upon irradiation by 360 nm light, the corresponding dicnq complex of nickel(II) was found to be ineffective under a similar set of experimental conditions.

TL;DR: In this article, the chemistry of NO and HNO with heme proteins in different redox states and observed that HNO favors reaction with ferric heme while NO favors ferrous, consistent with previous reports.

TL;DR: Findings support phosphatase inhibition as a mechanism for insulin sensitization by BMOV and other organovanadium compounds and strongly suggest that uncomplexed vanadium is the active component of these compounds.

TL;DR: The testicular sperm density, sperm morphology, sperm motility, density of cauda epididymis, spermatozoa and fertility in mating trials and the biochemical parameters of the reproductive organs of the rat were examined and are discussed.

TL;DR: In the presence of H(2)O(2), the complex of mono(1,10-phenanthroline)copper exhibits higher activity as a nuclease than bis(1-10- phenanthro line)coppers.

TL;DR: This review focuses on recent advances in arsenic-induced signal transduction, including reactive oxygen species (ROS) production, tyrosine phosphorylation, MAPK signaling, NF-kappaB activation, cell cycle arrest, and apoptosis.

TL;DR: Antibacterial activity screening of the above compounds suggests that nickel compounds 2, 3 and 4 were the most active and can act as potent antibacterial agents.

TL;DR: This animal model system involving neurotoxicity induced by an aluminum compound provides new information on mechanisms of neurodegeneration and neuroprotection.

TL;DR: Viscosity measurement showed that Copper (II) complex binds with DNA through intercalative mode, and induces cleavage in plasmid DNA in the presence of coreductants such as ascorbic acid or glutathione.

TL;DR: The interactions of quinolone ciprofloxacin (cfH) and oxovanadium(IV) were studied by various methods and it was established that its activity is similar to that of free ciprodexacin.

TL;DR: Five new organotin(IV) molecules with the heterocyclic thioamides, synthesized and characterized by elemental analysis, 1H-, 13C-NMR, FT-IR and Mössbauer spectroscopic techniques, exhibits strong cytotoxic activity, while complexes 1 and 3 show less cytot toxic activity.

TL;DR: A critical assessment of the large body of recent research into Cr chemistry and biochemistry in relation to its biological activities is made to rationalize the current state of knowledge with regard to implications for health, highlighting those areas that demand further study.

TL;DR: Speciation is shown to be dependent mainly on soil pH and organic matter quality, and a general scheme of Al fractionation and speciation in soil is proposed.

TL;DR: The bis-phen complex is a better cleaver of SC DNA than 1-5 having mono-heterocyclic base and the ancillary ligand is found to have less effect in DNA binding but are of importance in DNA cleavage reactions.

TL;DR: Estimation of secondary structural elements at various pH values indicated that there is a maximal reduction of beta-strands and beta-turns at pH 5.5 causing the heme to be further exposed to the solvent and increasing the overall conformational flexibility of the protein.

TL;DR: The results indicated that the two complexes interact with DNA in different binding modes, and complex 1 may bind to DNA via electrostatic interaction, while complex 2 binds to DNA by partial intercalation via the extended naphthyl ring into the base pairs of DNA.

TL;DR: The data support that Chit acts as steric stabilizer and inhibits the macroscopic aggregation of the subcolloidal FeOOH particles, thus the iron(III)-Chit interactions offer a simple and economic way to fabricate nanometric size FeOOh spheres, morphologically similar to the core of iron( III)-storage protein, ferritin.

TL;DR: It is concluded that the accumulation of Al in cells enhances the peroxidation of lipids exclusively under growing conditions, and that the higher content of ASA and GSH in AlT301 than in SL seems to be in part responsible for the tolerance mechanism of ALT301 to Al by protecting cells from either lipid peroxidated or H(2)O(2), commonly enhanced by Al or other oxidants.

TL;DR: Three new ternary peptide-Cu(II)-1,10-phenanthroline (phen) complexes have been prepared and structurally characterised and exhibit significant differences in their nuclease activity which depends on the nature of the peptidic moiety, the complex [Cu(gly-L-trp) (phen)]2H(2)O 3 being the most active.