Showing papers in "Journal of Inorganic Biochemistry in 2004"

TL;DR: The results from absorption spectral titration and circular dichroism (CD), thermal denaturation and viscosity experiments indicate that the qdppZ and hqdppz complexes bind more avidly than the ip, pip and hpip complexes, and the ammonia co-ligands of the complexes are possibly involved in hydrogen bonding with the intrastrand nucleobases to favour intercalation of the extended aromatic ligands.

TL;DR: A linear correlation between pH-meter readings in equivalent D2O and H2O solutions, determined experimentally, leads to a novel equation, which allows for a direct recalculation of pKa values measured in D 2O into a H 2O equivalent: pKH=0.929pKH*+0.42.

TL;DR: Using a number of cancer models, the increased expression of receptors also leads to increased levels of killing with targeted cytotoxins, which suggests that the use of vitamins as targeting agents has enormous potential for use in cancer diagnosis and chemotherapy.

TL;DR: The results of the study show that there is an interaction between curcumin and both cadmium and lead, with the possible formation of a complex between the metal and this ligand, implying that curcuming could be used therapeutically to chelate these toxic metals, thus potentially reducing their neurotoxicity and tissue damage.

TL;DR: Sophe is a sophisticated computer simulation software programme employing a number of innovative technologies including; the Sydney OPera HousE (SOPHE) partition and interpolation schemes, a field segmentation algorithm, the mosaic misorientation linewidth model, parallelization and spectral optimisation, which greatly increase the speed of simulations for most spin systems.

TL;DR: This review describes recent advances, in the routes of (64)Cu production, design and application of bi-functional ligands for use in radiolabelling with (64/67)Cu(2+), and their significance and anticipated impact on the field of molecular imaging and drug development.

TL;DR: The novel ternary copper(II) complex was shown to bind DNA by intercalation and cleave pBR322 DNA in the presence of ascorbate, and exhibited potent cytotoxic effects against human leukemia cell line HL-60 and human stomach cancer cell line SGC-7901 with inhibition rates of over 90%, however, less pronounced effects were observed.

TL;DR: A systematic study on intracellular Pt uptake and Pt accumulation ratio in breast cancer MCF-7 cell line has been performed on a number of Pt(II)-complexes and a very sensitive method of analysis like as inductively coupled plasma mass spectrometry (ICP-MS) superior to the widely employed atomic absorption spectroscopy (AAS) has been adopted.

TL;DR: The results suggest that the mechanism by which MMP is induced by these lipophilic cationic Au(I)-carbene complexes is not purely a function of the level of compound accumulation, and a more specific mechanism, possibly involving disruption of the function of a particular enzyme, or interaction with a MPT component, appears to be more likely.

TL;DR: It is proposed that the antimicrobial activities of theSilver(I)-oxygen bonding complexes are due to a direct interaction or complexation of the silver(I) ion with biological ligands such as protein, enzyme and membrane, and the coordinating ligands of thesilver(I).

TL;DR: Biological studies have shown that both ligands and some copper and nickel complexes are active in inhibiting cell proliferation, and the same compounds present only a precocious action on cell line NB4 and therefore their activity is cell target specific.

TL;DR: The experimental data are consistent with a mechanism by which Cu(II) oxidizes the complex Cys-Cu(I) to cystine producing aqueous Cu(I), which undergoes dismutation regenerating Cu( II), which plays a catalytic oxidative role in the absence of molecular oxygen.

TL;DR: It is concluded that gold compounds are highly specific inhibitors of mitochondrial thioredoxin reductase and this action influences other functions such as membrane permeability properties.

TL;DR: The location of xenon binding sites in CYP101 suggests a role for one of the pathways identified by molecular dynamics simulations as a route for gaseous species, such as oxygen, to access the active site.

TL;DR: It is proposed that the selective antimetastatic activity of NAMI-A during in vivo experiments can be attributed to its hydrolysed species, which apparently are easier taken up by the metGM cells, showing intracellular ruthenium concentrations one order of magnitude greater than those of intact NAMI

TL;DR: The experimental results indicate that the size and shape of the intercalated ligand have a marked effect on the binding affinity of complexes to CT-DNA.

TL;DR: The hypothesis of an external electrostatic interaction between the negatively charged DNA double helix and the axially stacked positively charged Fe(Salen)(+) moieties is supported, analogously to what reported for a number of porphyrazines and metal-porphyrazine complexes interacting with DNA.

TL;DR: This paper reports on a study of the interactions between arsenic(III) and either cysteine or glutathione in aqueous solution, and the behavior observed for the As(III)-glutathione system is very similar to that of As( III)-cysteine.

TL;DR: An octahedral structure has been confirmed for the complexes that were characterized by elemental analyses, Infra red, electronic, electron paramagnetic resonance spectroscopy and cyclic voltammetry and screened for their antibacterial properties.

TL;DR: A dimeric copper complex of the unsubstituted pyridoxal thiosemicarbazone, previously tested on Friend murine cell lines, has been recently resynthesized and compared, in vitro and in vivo, with its monomeric counterpart [Cu(H(2)L)(OH(2))Cl]Cl.

TL;DR: The reduction potentials, lipophilicities, cellular uptake and cytotoxicity have been examined for two series of platinum(IV) complexes that yield common platinum(II) complexes on reduction and results are interpreted in terms of reduction, followed by aquation reducing the amount of efflux from the cells resulting in an increase in net uptake.

TL;DR: The kinetics of the decomposition of H(2)O( 2) catalyzed by Cu(II) has been studied by the initial-rate method in aqueous phosphate media at near physiological pH.

TL;DR: The kinetics and mechanisms of the reactions of iron(III) with the hydroxy cinnamic acid based ligands caffeic, chlorogenic, sinapic and ferulic acids and the flavonoid naringin have been investigated and suggested mechanisms and calculated rate constants are validated by calculations carried out using global analysis of time dependent spectra.

TL;DR: It is proposed that La3+ can replace Ca2+ from the binding sites because of their close ionic radii and similar ligand specificities.

TL;DR: The finding that when mammalian and yeast cells are genetically engineered to express altered levels of the Cu transporters they exhibit altered sensitivity to Pt drugs and are defective in intracellular Pt accumulation due to altered uptake and/or efflux rates supports the significance of theCu homeostasis proteins as both markers of and contributors to Pt resistance.

TL;DR: Two asymmetric tridentate copper(II) complexes, prepared and characterized by elemental analysis, IR and Fast atomic bombardment mass spectra, are found to cause significant cleavage of double-strand pBR 322 DNA and [Cu(pta)Cl(2)] exhibited the higher cleaving efficiency.

TL;DR: The experimental data suggest that in all cases coordination of the dithiocarbamate ligand (ESDT) takes a place through the two sulfur atoms, the -NCSS moiety acting as a symmetrical bidentate chelating group, in a square-planar geometry around the M(II) ion.

TL;DR: A detailed kinetic analysis of the insertion and extension steps of dNTP incorporation in the vicinity of the adduct shows that both pol beta and pol eta catalyze translesion synthesis past oxaliplatin-GG adducts with greater efficiency than past cisplatin.

TL;DR: This study kept the ligand and dose the same, but varying instead the metal ion bound to the maltolato ligand in a series of binary complexes of neutral charge, finding no other metal ion tested served as a suitable substitute.

TL;DR: In both acute and chronic screening tests, VO(cur)2 was ineffective as an insulin mimetic agent; however, it also proved to be exceptionally non-toxic, with no evidence of negative symptomatology during a month-long treatment period.