Showing papers in "Journal of Inorganic Biochemistry in 2006"

TL;DR: The preclinical and early clinical development of KP1019 - from bench to bedside - is recapitulated and promising activity against certain types of tumors is observed.

TL;DR: Accumulated evidence shows that the ferryl species [Fe(IV)O](2+) can be formed under a variety of conditions including those related to the ferrous ion-hydrogen peroxide system known as Fenton's reagent, indicating that the oxygen rebound pathway is a ubiquitous mechanism for hydrocarbon oxygenation by both heme and non-heme iron enzymes.

TL;DR: A look back at the many questions asked and answered regarding vanadium's glucose-enhancing potential, its biodistribution and biomolecular transformation, and its mechanism(s) of action, and consider some of the newest developments in the field, including novel delivery methods for vanadium in diabetes treatment.

TL;DR: Crystallographic studies on 2-oxoglutarate oxygenases and related enzymes have revealed a common double-stranded beta-helix core fold that supports the residues coordinating the iron that is common to proteins of the cupin and the JmjC transcription factor families.

TL;DR: All the complexes show cleavage of pBR322 supercoiled DNA in the presence of ascorbic acid with the cleavage efficiency varying in the order 3 > 1 > 2 and the highest oxidative DNA Cleavage of dpq complex is ascribed to its highest Cu(II)/Cu(I) redox potential.

TL;DR: The results suggest that the ruthenium(II) complex binds to DNA via an intercalative mode and serves as a molecular "light switch" for DNA.

TL;DR: The biological and molecular properties of prokaryotic nitrate reductases are reviewed along with their gene organization and expression, which are necessary to understand the biological processes involved in nitrate reduction.

TL;DR: It is shown that a number of important structural features are conserved in the N-terminal domains of polyphenol oxidases from various plants and fungi, including a tyrosine motif which can be considered a landmark indicating the beginning of the linker region connecting the N - and C-Terminal domains.

TL;DR: This manuscript presents a concise updated review of the bioinorganic aspects of denitrification, an anaerobic process used by some bacteria for energy generation and its environmental implications have been given particular relevance.

TL;DR: These studies emphasize the important role the supporting polydentate ligand plays in eliciting the desired high-valent iron-oxo chemistry.

TL;DR: In this paper, a review of the most recent structural investigations for the different intermediates of these proteins is presented, in particular quantum refinement, which is a combination of QM calculations and crystallography.

TL;DR: Compound 3 was proven to be a broad spectrum agent and showed a significant inhibition of the growth of Gram-positive bacteria and pathogenic fungi and was found to be non-toxic to human erythrocytes even at a concentration of 500mug/mL.

TL;DR: The experimental results show that both these two isomer complexes can bind to DNA in an intercalative mode; the DNA-binding affinity of [Ru(bpy) 2 ( p -mopip)] 2 is greater than that of [ Ru( bpy)2 ( o -mopIP)] 1 ; moreover, theDNA-binding affinities of enantiomers Δ- 1 and Δ- 2 are all greater than those of Λ- 1

TL;DR: For the first time, Cu(II)-NSAID complexes can directly bind with the DNA backbone, and the binding constants and the stoichiometry or the binding site sizes have been determined.

TL;DR: DNA-binding studies indicate that, besides the intercalation, the complexes bind to DNA by the other interaction(s), which might be responsible for the production of more compact DNA, coinciding with more A-like feature of DNA as suggested by CD spectra.

TL;DR: The antimicrobial efficiency of the complexes has been tested on three different microorganisms and the available evidence supports that the best inhibition is provided by Cu(erx)2(H2O) (minimum inhibitory concentration=0.125 microg mL(-1)) against Escherichia coli and Pseudomonas aeruginosa.

TL;DR: This review advocate that there is still much to be learned from this pursuit of high-valent-iron enzyme intermediates and summarize the insight provided by two of the landmark discoveries and the subsequent studies that they spurred to support this contention.

TL;DR: The results indicate that the [Ni(RA)(2)(H(2)O)(2)] * H( 2)O can more effectively promote the cleavage of plasmid DNA than that of all-trans retinoic acid (HRA) and Ni(II) at physiological pH and temperature.

TL;DR: The current status of the isolation and characterization of the P450 oxo-Fe(IV) is examined and compared to analogous states in related heme enzymes, and the utilization of cofactor exchange to stabilize high-valent oxe-states in the P 450 is addressed.

TL;DR: The experimental data suggest that oxolinic acid acts as a deprotonated bidentate ligand and is coordinated to the metal ion through the pyridone and one carboxylate oxygen atoms, and that the complexes are bound to calf-thymus DNA.

TL;DR: Two trinuclear copper(II) complexes with linear or triangular metal-binding pendants have been synthesized and characterized and exhibited very high affinities towards DNA and strong destabilization of DNA, and were far better than their mononuclear analogues.

TL;DR: The results reveal similarities as well as some pronounced differences in the properties of the molecule in the two alternative spin states using density functional (DFT) and simplified correlated multireference ab initio methods.

TL;DR: Density functional calculations, which suggest that Mössbauer spectroscopy can be used to determine ferryl protonation states, are presented, and it is concluded that the ferryl forms of myoglobin, horseradish peroxidase, cytochrome c peroxido, and catalase are not basic.

TL;DR: Structural, crystallographic, textural, and chemical analysis of sponge spicules corroborates the view that nano-clustered crystal growth, induced by organic matrices, is a basic characteristic of biomineralisation that enables the production of composite materials with elaborate morphologies.

TL;DR: Molecular modeling studies show that the minimized structure of [Co(phendione)2Cl2]+, maintained the octahedral structure while binding to the N7 of guanines and the ligand fits into the major groove without disrupting the helical structure of the B-DNA.

TL;DR: The binding of different metals by mb suggests that methanotrophic activity also may play a role in either the solubilization or immobilization of many metals in situ.

TL;DR: Hb functions as a .NO dioxygenase by controlling O(2) binding and electrochemistry, guiding .NO diffusion and reaction, and shielding highly reactive intermediates from solvent water and biomolecules.

TL;DR: The cytotoxic activity shown by these compounds indicates that coupling of HFoTsc and HAcTsc to Zn(II) metal center result in metallic complexes with important biological properties since they display IC(50) values in a microM range similar to or better than that of the antitumor drug cis-platin.

TL;DR: This short review summarizes recent advances in the synthesis and reactivity of iron imides and nitrides, and monometallic and multimetallic assemblies featuring these moieties are discussed.

TL;DR: The synthesis, characterization and comparative biological study of a series of antibacterial copper complexes with heterocyclic sulfonamides were reported, showing that the 3H2O presented the highest antimicrobial potency and a superoxide dismutase-like activity comparable with pharmacological active compounds.